Phentolamine hydrochloride
- CAS No.
- 73-05-2
- Chemical Name:
- Phentolamine hydrochloride
- Synonyms
- c-7337;phentolaminechloride;Regitine hydrochloride;PHENTOLAMINE HYDROCHLORIDE;Phentolamine Hydrochloride (300 mg);Phentolamine hydrochloride USP/EP/BP;Phentolamine Hydrochloride (1529005);Phentolamine hydrochloride, Non-selective alpha antagonist;2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLINE HYDROCHLORIDE;m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonohydrochloride
- CBNumber:
- CB4358864
- Molecular Formula:
- C17H20ClN3O
- Molecular Weight:
- 317.81
- MDL Number:
- MFCD00079268
- MOL File:
- 73-05-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >230 (dec.)°C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | methanol: 10 mg/mL, clear, colorless |
| form | powder |
| color | white to off-white |
| Merck | 13,7348 |
| BRN | 3764617 |
| InChI | 1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H |
| InChIKey | TUEJFGFQYKDAPM-UHFFFAOYSA-N |
| SMILES | Cl[H].Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3 |
| CAS DataBase Reference | 73-05-2 |
| FDA UNII | 86DRW83R1H |
| UNSPSC Code | 12352116 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn,C |
| Risk Statements | 22-34 |
| Safety Statements | 22-24/25-45-36/37/39-27-26 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | SL0701000 |
| F | 3-10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LD50 in rats (mg/kg): 75 i.v.; 275 s.c.; 1250 orally (Meier) |
Phentolamine hydrochloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P7547 | Phentolamine hydrochloride ≥98% (TLC), powder | 73-05-2 | 100mg | $117 | 2026-04-30 | Buy |
| Sigma-Aldrich | P7547 | Phentolamine hydrochloride ≥98% (TLC), powder | 73-05-2 | 500mg | $474 | 2026-04-30 | Buy |
| Usbiological | P4047 | Phentolamine, Hydrochloride (2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline, Hydrochloride) | 73-05-2 | 250mg | $439 | 2026-06-03 | Buy |
| Biosynth | FP26895 | Phentolamine hydrochloride | 73-05-2 | 0.05g | $250 | 2026-06-04 | Buy |
| Biosynth | FP26895 | Phentolamine hydrochloride | 73-05-2 | 0.025g | $250 | 2026-06-04 | Buy |
Phentolamine hydrochloride Chemical Properties, Uses, Production
Chemical Properties
Phentolamine hydrochloride is Tan Solid
Originator
Regitine, Ciba, US ,1952
Uses
Phentolamine Hydrochloride ia an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.
Uses
anesthetic (local); inhibitor of DRG IA/Kv4.2 current
Uses
Phentolamine hydrochloride is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.
Manufacturing Process
199.24 parts of N-(p-methylphenyl)-m'-hydroxyphenylamine and 77.52 parts of 2-chloromethylimidazoline hydrochloride are heated for sixteen hours in an oil bath having a temperature of 150°C, while stirring and introducing a current of nitrogen. The viscous contents of the flask are then cooled to about 100°C, mixed with 400 parts by volume of hot water, and stirred for a short time.
After further cooling to about 60°C, 200 parts by volume of water and 500 parts by volume of ethyl acetate at 60°C are added, and the aqueous layer is separated. The excess of starting material may be recovered from the ethyl acetate.
The aqueous portion is chilled in a cooling chamber at -10°C, whereupon the hydrochloride of 2-[N-(p-methylphenyl)-N-(m'-hydroxyphenyl)-aminomethyl]imidazoline crystallizes. Upon being concentrated and cooled the mother liquor yields a further quantity of the hydrochloride. The combined quantities of hydrochloride are treated with a small quantity of cold water, dried with care, and washed with ethyl acetate. The product is then crystallized from a mixture of alcohol and ethyl acetate, and there is obtained a hydrochloride melting at 239°-240°C.
brand name
Regitine Hydrochloride (Ciba-Geigy).
Therapeutic Function
Adrenergic blocker
Biochem/physiol Actions
α-adrenoceptor antagonist; peripheral vasodilator.
Phentolamine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| NingBo Sialon Chem Co., Ltd. | 0574-28809768 18658497215 | sales@newsialon.com | China | 40 | 58 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Phentolamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Phentolamine hydrochloride
73-05-2
|
10g | TargetMol Chemicals Inc. | ||||
 |
2020-05-12 | PhentolaMine Hydrochloride
73-05-2
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- Phentolamine hydrochloride
73-05-2
- TargetMol Chemicals Inc.
-
- PhentolaMine Hydrochloride
73-05-2
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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