ChemicalBook >> CAS DataBase List >>2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE structure

CAS No.: 945-24-4

Chemical Name:: 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE

Synonyms: Methotrexate EP Impurity A;AKOS 213-118;Methotrexate-EP-Imp-A;Methotrexate IMpurity A;Pralatrexate Impurity 3;Methotrexate Impurity 1(EP-A);2,4-Diaminopteridine-6-methanol;2,4-DIAMINO-6-PTERIDINEMETHANOL;2,4-diaminopteridine-6-ylmethanol;6-pteridinemethanol, 2,4-diamino-

CBNumber:: CB4364405

Molecular Formula:: C7H8N6O

Molecular Weight:: 192.18

MDL Number:: MFCD00006711

MOL File:: 945-24-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:21:12

Product description	Number	Pack Size	Price
2,4-Diamino-6-(hydroxymethyl)pteridine 95%	861634	25mg	$82.5
2,4-Pteridinediamine-6-methanol	P840095	25mg	$65
2,4-Pteridinediamine-6-methanol	P840095	250mg	$155
2,4-Diamino-6-(hydroxymethyl)pteridine	3136AH	25g	$370
(2,4-Diaminopteridin-6-yl)methanol	CS-B0318	1g	$104
More product size

Request For Quotation

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE Properties

Melting point	333-334 °C (decomp)
Boiling point	560.2±60.0 °C(Predicted)
Density	1.673±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	12.00±0.10(Predicted)
form	Solid
color	Light Brown to Dark Yellow
InChI	InChI=1S/C7H8N6O/c8-5-4-6(13-7(9)12-5)10-1-3(2-14)11-4/h1,14H,2H2,(H4,8,9,10,12,13)
InChIKey	CYNARAWTVHQHDI-UHFFFAOYSA-N
SMILES	N1=C2C(N=C(CO)C=N2)=C(N)N=C1N
CAS DataBase Reference	945-24-4(CAS DataBase Reference)
FDA UNII	1RU16O4RO0
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	861634	2,4-Diamino-6-(hydroxymethyl)pteridine 95%	945-24-4	25mg	$82.5	2026-03-19	Buy
TRC	P840095	2,4-Pteridinediamine-6-methanol	945-24-4	25mg	$65	2021-12-16	Buy
TRC	P840095	2,4-Pteridinediamine-6-methanol	945-24-4	250mg	$155	2021-12-16	Buy
AK Scientific	3136AH	2,4-Diamino-6-(hydroxymethyl)pteridine	945-24-4	25g	$370	2021-12-16	Buy
ChemScene	CS-B0318	(2,4-Diaminopteridin-6-yl)methanol	945-24-4	1g	$104	2021-12-16	Buy

Product number	Packaging	Price	Buy
861634	25mg	$82.5	Buy
P840095	25mg	$65	Buy
P840095	250mg	$155	Buy
3136AH	25g	$370	Buy
CS-B0318	1g	$104	Buy

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE Chemical Properties,Uses,Production

Chemical Properties

Orange-Yellow Solid

Uses

2,4-Pteridinediamine-6-methanol (Methotrexate EP Impurity A) is an impurity of Methotrexate. A useful reagent for the development of selective antiparasitic compounds.

Synthesis

96-26-4

5392-28-9

945-24-4

1. Barium chloride (7.32 g, 30 mmol) was added rapidly to an aqueous suspension of tetraaminopyrimidine sulfate (7.14 g, 30 mmol). The reaction mixture was heated at 100 °C for 10 min and then cooled to room temperature. The resulting barium sulfate solid was removed by filtration. 2. The above filtrate was transferred to a 1 L three-necked round-bottomed flask fitted with a mechanical stirrer pre-filled with 450 mL of an aqueous 4 M sodium acetate solution containing dihydroxyacetone (8 g, 90 mmol) and cysteine hydrochloride monohydrate (3.63 g, 30 mmol). The reaction mixture was stirred at room temperature, open to air for 24 hours. 3. Upon completion of the reaction, the precipitated yellow solid was collected by filtration, washed sequentially with water and ethanol, and subsequently dried in a heated vacuum oven overnight to afford 3.4 g (66% yield) of the crude product 2,4-diamino-6-hydroxymethylpteridine. 4. Purification of the crude product: the yellow solid was dissolved in 10% acetic acid and a few drops of concentrated hydrochloric acid were added. The solution was heated to 75°C, treated with the addition of activated carbon and subsequently thermally filtered. 5. Neutralize the filtrate with ammonia to neutral and precipitate a bright yellow solid. The solid was collected by filtration, washed sequentially with water, water-ethanol mixture and ethanol, and finally dried overnight in a heated vacuum oven to give 2.8 g (54% yield) of purified 2,4-diamino-6-hydroxymethylpteridine.

References

[1] Patent: WO2010/110907, 2010, A1. Location in patent: Page/Page column 48-49

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE synthesis

Synthesis of 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE from (2,4-DIAMINOPTERIDIN-6-YL)METHANOL HYDROCHLORIDE HYDRATE

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE Preparation Products And Raw materials

Raw materials

(2,4-DIAMINOPTERIDIN-6-YL)METHANOL HYDROCHLORIDE HYDRATE 2,4,5,6-TETRAAMINOPYRIMIDINE Pyrimidinetetramine sulfate DL-Cysteine hydrochloride 1,3-Dihydroxyacetone

Barium chloride Sodium acetate

1of2

Preparation Products

Aminopterin 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE Suppliers

Global( 155)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2542	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3590	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15079	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58

Supplier	Advantage
career henan chemical co	58
Standardpharm Co. Ltd.	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
AFINE CHEMICALS LIMITED	58
sgtlifesciences pvt ltd	58
Nanjing Doge Biomedical Technology Co., Ltd	58

View Lastest Price from 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-12	2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE 945-24-4	US $1.00-0.00 / KG	1KG	99%	10000KG	Shaanxi Dideu Medichem Co. Ltd
2020-02-26	2,4-PteridinediaMine-6-Methanol 945-24-4	US $1.00-1.00 / KG	1KG	99%+	100 tons	Shaanxi Dideu Medichem Co. Ltd
2020-02-26	2,4-Pteridinediamine-6-Methanol 945-24-4	US $0.00-0.00 / Kg	1KG	99.0%+	100 tons	Shaanxi Dideu Medichem Co. Ltd

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE
945-24-4
US $1.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

2,4-PteridinediaMine-6-Methanol
945-24-4
US $1.00-1.00 / KG
99%+
Shaanxi Dideu Medichem Co. Ltd

2,4-Pteridinediamine-6-Methanol
945-24-4
US $0.00-0.00 / Kg
99.0%+
Shaanxi Dideu Medichem Co. Ltd

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE Spectrum

2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE(945-24-4)¹HNMR 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE(945-24-4)IR

945-24-4(2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE)Related Search:

D(-)-AMETHOPTERIN Methotrexate Related Compound E (50 mg) (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, hemihydrochloride) N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID Methotrexate EP Impurity G Aminopterin

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]- Methotrexate 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid 4-(HYDROXYMETHYL)BENZONITRILE

2,4-DIAMINO-6-(HYDROXYMETHYL)-PTERIDINE HYDROBROMIDE 2,4-DIAMINO-6-HYDROXYMETHYL PTERIDINE HYDROBROMID 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE HYDROCHLORIDE HYDRATE,2,4-Diamino-6-(Hydroxymethyl)pteridine HCl,2,4-diamino-6-(hydroxymethyl)pteridine hydrocloride 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE HYDROCHLORIDE

1of3

AKOS 213-118 (2,4-DIAMINO-PTERIDIN-6-YL)-METHANOL (2,4-DIAMINO-6-PTERIDINYL)METHANOL 2,4-DIAMINO-6-PTERIDINEMETHANOL 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE 2,4-diaminopteridine-6-ylmethanol 2,4-Diamino-6-hydroxymethylpteridine hydrochloride or HBR 2,4-DIAMINO-6-HYDROXYMETHYLPTERIDINE, 95 % 2,4-Diaminopteridine-6-methanol Methotrexate-EP-Imp-A 2,4-Diamino-6-(hydroxymethyl)pteridine 95% 6-pteridinemethanol, 2,4-diamino- Methotrexate EP Impurity A Methotrexate Impurity 1(EP-A) Methotrexate IMpurity A Pralatrexate Impurity 3 Methotrexate Impurity 1（Methotrexate EP Impurity A） 2, 4-diamino-6-hydroxymethylterenidine 945-24-4 Quinazolines Heterocyclic Building Blocks Building Blocks Benzhydrols, Benzyl & Special Alcohols Heterocycles Aromatics Compounds Aromatics Bases & Related Reagents Inhibitors Nucleotides