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ChemicalBook >> CAS DataBase List >>2-Chloro-1-(3,4-difluoro-phenyl)-ethanone

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Structure
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone structure
CAS No.
51336-95-9
Chemical Name:
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
Synonyms
2-Chloro-1-(3,4-difluorophenyl)ethan-1-one;Fluconazole Impurity 6;Ticagrelor Impurity 148;3,4-Difluorophenacyl chloride;α-Chloro-3,4-difluorobenzophenone;a-Chloro-3,4-difluoroacetophenone;2-Chloro-3',4'-difluoroacetophenone;2-chloro-1(3,4-difuorophenyl)ethanone;Ethanone,2-chloro-1-(3,4-difluorophenyl)-;2-CHLORO-1-(3,4-DIFLUORO-PHENYL)-ETHANONE
CBNumber:
CB4366171
Molecular Formula:
C8H5ClF2O
Molecular Weight:
190.57
MDL Number:
MFCD03966888
MOL File:
51336-95-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-22 20:19:50
Product description Number Pack Size Price
2-Chloro-3',4'-difluoroacetophenone >98.0%(GC) C3215 1g $24
2-Chloro-3',4'-difluoroacetophenone >98.0%(GC) C3215 5g $71
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone FC86221 100g $260
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone FC86221 250g $520
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone FC86221 500g $910
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2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Properties

Melting point 31-32 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point 256.3±25.0 °C(Predicted)
Density 1.353±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Methanol
form powder to lump
color White to Light yellow
Sensitive Lachrymatory
InChI InChI=1S/C8H5ClF2O/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3H,4H2
InChIKey VMEDAWUIKFAFJQ-UHFFFAOYSA-N
SMILES C(=O)(C1=CC=C(F)C(F)=C1)CCl
CAS DataBase Reference 51336-95-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314-H290
Precautionary statements  P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
Hazard Codes  C,Xi
RIDADR  UN 3261 8/PG II
HazardClass  IRRITANT
PackingGroup  II
HS Code  2914790090
REACH Registrations Active
NFPA 704
0
3 0

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C3215 2-Chloro-3',4'-difluoroacetophenone >98.0%(GC) 51336-95-9 1g $24 2026-04-30 Buy
TCI Chemical C3215 2-Chloro-3',4'-difluoroacetophenone >98.0%(GC) 51336-95-9 5g $71 2026-04-30 Buy
Biosynth FC86221 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 51336-95-9 100g $260 2026-06-04 Buy
Biosynth FC86221 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 51336-95-9 250g $520 2026-06-04 Buy
Biosynth FC86221 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 51336-95-9 500g $910 2026-06-04 Buy
Product number Packaging Price Buy
C3215 1g $24 Buy
C3215 5g $71 Buy
FC86221 100g $260 Buy
FC86221 250g $520 Buy
FC86221 500g $910 Buy

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Chemical Properties,Uses,Production

Uses

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone is mainly used as an organic synthesis intermediate component.  It can be used to prepare (1R,2R)-Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate, (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2- phenylacetate, and 2-Arylcyclopropylamines.

Synthesis

2-chloro-1-(3,4-difluorophenyl)ethanone preparation steps are as follows: quickly weigh 10.2g anhydrous aluminum trichloride, (finely ground), added to a dry four-necked flask, and immediately add 11.4mL of o-difluorobenzene (dried), the middle of the mouth mounted electric stirrer, the side of the mouth, respectively, the installation of thermometers, constant-pressure dropping funnel (containing a certain amount of purified acetic anhydride, the top of the spherical condensing tube Connected to a dry tube equipped with anhydrous calcium chloride and toxic gas absorption device (absorption solution for 5% NaOH solution), under uniform stirring, from the constant pressure dropping funnel slowly dripping acetic anhydride, adjust the drop acceleration, so that the reaction temperature is controlled at 60 below the temperature rise in the process of dropping, there are a large number of white gas escapes, the solution color deepens, dropping is completed, the solution is lavender viscous. Heating reflux reaction with an oil bath until no HCl gas escapes, the solution becomes light brown. Remove the gas absorption device, after cooling, the four-necked flask in a cold water bath, add a certain amount of ice-water mixture under stirring, the solids are all dissolved (if not dissolved, add a small amount of concentrated hydrochloric acid dropwise). The reaction is transferred to a partition funnel, the organic layer is separated, the aqueous layer is extracted with toluene in two batches, and finally the toluene layer is combined, the toluene layer is washed with 5% NaOH solution, distilled water, respectively, until the aqueous layer is pH=7. The toluene as well as a small amount of the water mixture is removed by rotary evaporation and recovered, and the residue is subjected to decompression distillation for the collection of 25 . The fraction at 125-126C at mmHg (boiling point of 2-chloro-1-(3,4-difluorophenyl)ethanone is 245-247C at atmospheric pressure) was a brown oily liquid.

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone synthesis

367-11-3
79-04-9
51336-95-9
Synthesis of 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone from 1,2-Difluorobenzene and Chloroacetyl chloride

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Preparation Products And Raw materials

Raw materials

1,2-Difluorobenzene Chloroacetyl chloride

Preparation Products

(S)-2-(3,4-Difluorophenyl)oxirane 2-AMINO-4-(3,4-DIFLUOROPHENYL)THIAZOLE (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Suppliers

Global( 266)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Xinchem Co., Ltd.
+86-021-34123252 +8618049800532 xinchem@xinchem.com China 49 58
Biviture Industrial Limited
+86-86-17786030126 +8615618508769 luna@biviture.com China 84 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20121 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
Shanghai Xinchem Co., Ltd.
58
Biviture Industrial Limited
58
Anhui Ruihan Technology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Standardpharm Co. Ltd. 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone pictures 2026-07-14 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
51336-95-9
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-1-(3,4-difluorophenyl)ethanone pictures 2026-07-09 2-Chloro-1-(3,4-difluorophenyl)ethanone
51336-95-9
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone pictures 2026-06-30 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
51336-95-9
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Spectrum

2-Chloro-1-(3,4-difluoro-phenyl)-ethanone(51336-95-9)1HNMR2-Chloro-1-(3,4-difluoro-phenyl)-ethanone(51336-95-9)FT-IR

51336-95-9(2-Chloro-1-(3,4-difluoro-phenyl)-ethanone)Related Search:

4'-(Trifluoromethyl)acetophenone 2-chloro-1-(2,3-difluorophenyl)ethanone DIPHENYLCYCLOPROPENONE L-PICEIN Chlorodimethylphenylsilane
tert-Butylchlorodiphenylsilane Triphenylmethyl Chloride 4-Fluoroacetophenone PHENYL VALERATE 3'-Chloroacetophenone
CHLOROPHENYLSILANE Ticagrelor Sulfone 2-(((3aR,4S,6R,6aS)-6-(7-aMino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2-diMethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol (3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2- Ticagrelor Related Compound 3
TRANSAMINE 1,2-Cyclopentanediol, 3-[7-aMino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyriMidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)- 4-Chloro-2-propylsulfanyl-pyrimidine

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2-CHLORO-1-(3,4-DIFLUORO-PHENYL)-ETHANONE 3,4-Difluorophenacyl chloride a-Chloro-3,4-difluoroacetophenone Ethanone,2-chloro-1-(3,4-difluorophenyl)- Fluconazole Impurity 6 Ticagrelor Impurity 148 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone ISO 9001：2015 REACH 2-chloro-1(3,4-difuorophenyl)ethanone 2-Chloro-3',4'-difluoroacetophenone 2-Chloro-1-(3,4-difluorophenyl)ethanone (CFBA) α-Chloro-3,4-difluorobenzophenone 2-Chloro-1-(3,4-difluorophenyl)ethan-1-one 51336-95-9 Acetophenone series Methyl Halides Phenyls & Phenyl-Het Methyl Halides Phenyls & Phenyl-Het