[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
![[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Structure](CAS/20180601/GIF/951612-19-4.gif)
- CAS No.
- 951612-19-4
- Chemical Name:
- [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
- Synonyms
- L524-0366;L524-0366, 10 mM in DMSO;L524 0366,L5240366,L-524-0366;[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone;4-[1-(3-Chlorophenyl)-1H-1,2,3-triazole-4-carbonyl]thiomorpholine;(1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone;Methanone, [1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-4-thiomorpholinyl-
- CBNumber:
- CB43916832
- Molecular Formula:
- C13H13ClN4OS
- Molecular Weight:
- 308.79
- MDL Number:
- MOL File:
- 951612-19-4.mol
| storage temp. | -20°C (des.) |
|---|---|
| solubility | Soluble in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming). |
| form | solid |
| color | Beige |
| Stability | Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Chemical Properties,Uses,Production
Description
L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD?= 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM.1?L524-0366 is the first compound known to interfere with the TWEAK/Fn14 interaction and may serve as a lead compound for the development of new therapeutics.2
Uses
TWEAK-Fn14-IN-1 (Compound L524-0366) is a specific dose-dependent TWEAK-Fn14 inhibitor. TWEAK-Fn14-IN-1 binds specifically to the Fn14 surface with a KD of 7.12 μM. TWEAK-Fn14-IN-1 inhibits TWEAK induced glioma cell migration without any potential cytotoxic effects[1].
References
[1] HARSHIL DHRUV. Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis.[J]. The Journal of Biological Chemistry, 2013: 32261-32276. DOI:10.1074/jbc.m113.493536
[2] EMILY CHENG. TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic.[J]. ACS Applied Materials & Interfaces, 2013: 473. DOI:10.3389/fimmu.2013.00473
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Preparation Products And Raw materials
Raw materials
Preparation Products
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29545 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Guangzhou Kaiyue Biotechnology Co., Ltd. | 15989108457 | CHINA | 164 | 58 |
