L-Isoserine
- CAS No.
- 632-13-3
- Chemical Name:
- L-Isoserine
- Synonyms
- (S)-ISOSERINE;(S)-3-Amino-2-hydroxypropanoic acid;L-ISOSERINE;(S)-LSOSERINE;L-Isoserine>
L -Isoserine;L-Isoserine USP/EP/BP;(S)-isoserine, 99%min;(S)-2-HYDROXY-B-ALANINE;(s)-2-hydroxy-β-alanine
- CBNumber:
- CB4394257
- Molecular Formula:
- C3H7NO3
- Molecular Weight:
- 105.09
- MDL Number:
- MFCD03428326
- MOL File:
- 632-13-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 199~201℃ |
|---|---|
| Boiling point | 386.6±27.0 °C(Predicted) |
| Density | 1.415±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | pK1:2.72(+1);pK2:9.25(0) (25°C,μ=0.16) |
| color | White to Almost white |
| optical activity | Consistent with structure |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 |
| InChIKey | BMYNFMYTOJXKLE-REOHCLBHSA-N |
| SMILES | C(O)(=O)[C@@H](O)CN |
| CAS DataBase Reference | 632-13-3(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P362+P364 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 2922500090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
L-Isoserine price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 06054 | L-Isoserine ≥98.0% (TLC) | 632-13-3 | 1G-F | $155 | 2023-06-20 | Buy |
| Sigma-Aldrich | 06054 | L-Isoserine ≥98.0% (TLC) | 632-13-3 | 1g | $155 | 2023-01-07 | Buy |
| TCI Chemical | I0828 | L-Isoserine >98.0%(T) | 632-13-3 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | I0828 | L-Isoserine >98.0%(T) | 632-13-3 | 5g | $41 | 2026-04-30 | Buy |
| ChemScene | CS-W013683 | L-Isoserine ≥98% | 632-13-3 | 25g | $20 | 2026-06-04 | Buy |
L-Isoserine Chemical Properties, Uses, Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
reaction suitability
reaction type: solution phase peptide synthesis
Biological Activity
Research has found that L-isoserine showed the ability to inhibit Aminopeptidase N (APN) at a half-maximal inhibitory concentration (IC50 ) value of 563 μM, which could serve as a new lead compound for further chemical modification and optimization. In addition, it has been reported that L-isoserine-L-leucine dipeptide shows moderate aminopeptidase B inhibitory activity (IC50 of 140 μM). This evidence indicates that the incorporation of an amino acid to L-isoserine may contribute to its inhibitory activity against APN. L-isoserine induces long-lasting effects by increasing the expression of GAT3 (glial GABA transporte) in peri-infarct regions[1-2].
References
[1] Yang K , et al. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors. Journal of Enzyme inhibition and Medicinal Chemistry, 2011; 27: 302-310.
[2] Lie M , et al. GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 2017; 39.
L-Isoserine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong puyue biomedical Co., Ltd | 0513-0513-0513-89158300 18014392889 | sales@puyerbiopharma.com | China | 4956 | 58 |
| Sichuan HongRi Pharma-Tech Co., Ltd | 1898-2685405 18380436509 | 2065506070@qq.com | China | 1930 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Suzhou haiyu Biochem Industrial Co., LTD | 512-68097639 18013585858 | 744942877@qq.com | China | 915 | 62 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from L-Isoserine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | L-Isoserine
632-13-3
|
1kg | 99% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2020-01-05 | L-Isoserine
632-13-3
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- L-Isoserine
632-13-3
- 99%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- L-Isoserine
632-13-3
- $1.00
- 99%
- Career Henan Chemical Co
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