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4-Cloromethyl-5-methyl-1,3-dioxol-2-one

4-Cloromethyl-5-methyl-1,3-dioxol-2-one structure

CAS No.: 80841-78-7

Chemical Name:: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one

Synonyms: DMDO-CL;4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE;Olmesartan impurity;4-ChloroMethyl-5-Methyl-1;AZATMint-C;DMDO-Chloride;Olmesartan Impurity 3;Olmesartan Impurity 57;Olmesartan Medoxomil IMP;4,5- dinmethyl-1,3-dioxol-2-

CBNumber:: CB4416605

Molecular Formula:: C5H5ClO3

Molecular Weight:: 148.54

MDL Number:: MFCD07787494

MOL File:: 80841-78-7.mol

Last updated:2025-07-24 18:13:53

Product description	Number	Pack Size	Price
4-Chloromethyl-5-methyl-1,3-dioxol-2-one >94.0%(GC)	C1882	5g	$77
4-Chloromethyl-5-methyl-1,3-dioxol-2-one >94.0%(GC)	C1882	25g	$281
4-Chloromethyl-5-methyl-1,3-dioxol-2-one	C369335	1g	$65
4-Chloromethyl-5-methyl-1,3-dioxol-2-one	C369335	10g	$175
4-Chloromethyl-5-methyl-1,3-dioxol-2-one,tech.	A537	500g	$320
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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Properties

Boiling point	>90℃/2mm
Density	1.362±0.06 g/cm3(Predicted)
refractive index	1.4760-1.4820
Flash point	129 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	liquid
Specific Gravity	1.36
color	Colorless to Light yellow to Light orange
BRN	4798926
InChI	InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
InChIKey	QCLFSYYUWPUWQR-UHFFFAOYSA-N
SMILES	CC1=C(OC(=O)O1)CCl
CAS DataBase Reference	80841-78-7(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS06

Signal word

Warning

Hazard statements

H302-H315-H319-H335-H301

Precautionary statements

P280a-P301+P310a-P405-P501a-P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

WGK Germany

HS Code

29329990

NFPA 704

	1
2		0

4-Cloromethyl-5-methyl-1,3-dioxol-2-one price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C1882	4-Chloromethyl-5-methyl-1,3-dioxol-2-one >94.0%(GC)	80841-78-7	5g	$77	2025-07-31	Buy
TCI Chemical	C1882	4-Chloromethyl-5-methyl-1,3-dioxol-2-one >94.0%(GC)	80841-78-7	25g	$281	2025-07-31	Buy
TRC	C369335	4-Chloromethyl-5-methyl-1,3-dioxol-2-one	80841-78-7	1g	$65	2021-12-16	Buy
TRC	C369335	4-Chloromethyl-5-methyl-1,3-dioxol-2-one	80841-78-7	10g	$175	2021-12-16	Buy
AK Scientific	A537	4-Chloromethyl-5-methyl-1,3-dioxol-2-one,tech.	80841-78-7	500g	$320	2021-12-16	Buy

Product number	Packaging	Price	Buy
C1882	5g	$77	Buy
C1882	25g	$281	Buy
C369335	1g	$65	Buy
C369335	10g	$175	Buy
A537	500g	$320	Buy

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties,Uses,Production

Description

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide.

Chemical Properties

Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.

Uses

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.

Preparation

4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.

Synthesis

37830-90-3

80841-78-7

General procedure for the synthesis of 4-chloromethyl-5-methyl-1,3-dioxolan-2-one from 4,5-dimethyl-1,3-dioxolan-2-one: To a stirred solution of 4,5-dimethyl-1,3-dioxolan-2-one (DMDO) were added 4725 g of ethylene dichloride, 10.12.5 g of N-chlorosuccinimide (NCS) and 45 g of benzoyl peroxide (BPO), the reaction temperature was maintained at 90 °C, and the reaction lasted for 5.5 h. The crude product 4-chloromethyl-5-methyl-1,3-dioxolen-2-one (DMDO-Cl) was obtained as 382.5 g in 85.00% yield. Step 3: distillation: the crude product of DMDO-Cl was distilled under vacuum at -0.1 MPa at 110 °C to obtain 326 g of DMDO-Cl. Its purity was 99.06% as determined by gas chromatography (GC).

References

[1] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 6, p. 2241 - 2248
[2] Chemical and Pharmaceutical Bulletin, 1988, vol. 36, # 1, p. 394 - 397
[3] Patent: US4554358, 1985, A
[4] Patent: CN107892681, 2018, A. Location in patent: Paragraph 0015-0022

4-Cloromethyl-5-methyl-1,3-dioxol-2-one synthesis

Synthesis of 4-Cloromethyl-5-methyl-1,3-dioxol-2-one from 4,5-Dimethyl-1,3-dioxol-2-one

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

4,5-Dimethyl-1,3-dioxol-2-one

Preparation Products

Trityl olmesartan Trityl Olmesartan Medoxomil

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Suppliers

Global( 618)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	+86-0373-3695376 +86-13937349994	HYJM@houyuanjm.com	China	299	58
Zhuhai Hairuide Bioscience and Technology Co., Ltd	+8618928027945	sales3@zhhairuide.com	China	97	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504	sales8@hbganmiao.com	China	300	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55

Supplier	Advantage
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	58
Zhuhai Hairuide Bioscience and Technology Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Hebei Ganmiao New material Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7	US $0.00 / Kg/Drum	1KG	98%min	1000kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2025-10-17	4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	4-Chloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7	US $8.00-0.80 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

4-Cloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

4-Cloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7
US $8.00-0.80 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Spectrum

4-Cloromethyl-5-methyl-1,3-dioxol-2-one(80841-78-7)¹HNMR

80841-78-7(4-Cloromethyl-5-methyl-1,3-dioxol-2-one)Related Search:

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Olmesartan Olmesartan Methyl

1of4

DMDO-CL 4-Cloromethyl-5-methyl-1,3-dioxol-2-one Olmesartan Impurity 57 4-CloroMethyl-5-Methyl-1,3-dioxol-2-one (DMDO-Cl) OlMesartan IMpurity (4-(ChloroMethyl)-5-Methyl-1,3-Dioxol-2-one) 4- chloroMethyl-5- Methyl-1,3- two oxygenheterocyclicpentadiene-2- ketone -5--1,3- two4-chloroMethylMethylcyclopentene-2- ketoneheterocyclic oxygen 4-ChloroMethyl-5-Methyl-l,3-dioxocyclopenten-2–one DMDO-CL: 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one Olmesartan impurity Olmesartan Medoxomil IMP AZATMint-C 4-( Cyclomethyl carbonyl ) -5 - methyl – 1,3-dioxol-2-one ( OLM 45 ) Olmesartan Impurity 3 4-Cloromethyl-5-methyl-1,3-dioxol-2-one in stock Factory Olmesartan Medoxomil Impurity 56 Olmesartan Medoxomil Impurity 5 4-CHLOROMETHYL-5-METHYL-2-OXO-1,3-DIOXOLE 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOLEN-2-ONE DMDO CL (4-METHYL-5-CHLOROMETHYL-1,3-DIOXOL-2-ONE) 4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(Dmdo-Cl) 4-Chloromethyl-5-Methyl-1,3-Dioxocyclopenten-2-one 4-Chloromethyl-5-methyl-2H-1,3-dioxol-2-one 4-Choromethyl-5-methyl-2-oxo-1,3-dioxole 4-Chloromethyl-5-Methyl-1,3-Di 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-3-ONE 4-methyl-5-chloro methyl-1,3-dioxol-2-one 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE (INTERMEDIATE OF OLMESARTAN MEDOXOMIL) 4-Chloromethyl-5-methyl-1,3-dioxol-2-on 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE HPLC 95% 4-Methyl-5-(chloromethyl)-1,3-dioxole-2-one 4-ChloroMethyl-5-Methyl-1 4-chloroMethyl-5-Methyl-1,3-dioxdene-2-one (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Chloride 4-(chloroMethyl)-5-Methyl-1,3-dioxol-2-oneSynonyMs 1,3-Dioxol-2-one, 4-(chloromethyl)-5-methyl- Olmesartan Medoxomil Impurity 5 (4-(Chloromethyl)-5-methyl-1,3-Dioxol-2-one) 4-Chloromethyl-5-methyl-1,3-dioxol-2-one > Olmesartan Chloromethyl Impurity Olmesartan Medoxomil EP Impurity 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ISO 9001：2015 REACH 4-chloromethyl-5-methyl-1,3-Dioxol-2-oneQ: What is 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the CAS Number of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the storage condition of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What are the applications of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one 4-CHLORO METHYL-5-METHYL-1,3-DAIOXOL,2-ONE(DMDO.CL) 4,5- dinmethyl-1,3-dioxol-2- 4-ChlDMDO-Cloromethyl-5-methyl-1,3-dioxol-2-one 4-Chloromethyl-5-methyl-1,3-Dioxole -2-one (DMDO CL) 4-Chloromethyl-5-MethyI-1 ,3-Diox0l-2-One(DMDO-CI) 4-Chlomethyl-5-methy1-1,3,dioxol-2-one Olmesartan Medoxomil Impurity 5 (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Chloride 4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(DMDO-CI) 4-chloromethyl-5-methyl-1,3-dioxolane-2-one 4-Chloromethyl-5-methyl-1,3-dioxl-2-one DMDO-Chloride 4-Chloromethyl-5-methyl-1,3-Dioxol-2-one (DMDO Chloride ) 80841-78-7 C5H5ClO3 C5H5O3Cl