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L-Lactide

L-Lactide structure

CAS No.: 4511-42-6

Chemical Name:: L-Lactide

Synonyms: LACTIDE;L-LA;L-(-)-LACTIDE;LL-Lactide;L,L-Dilactide;(3S)-CIS-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE;actide;-(-)-L;(3S,6S);L-LACTIDE

CBNumber:: CB4416791

Molecular Formula:: C6H8O4

Molecular Weight:: 144.13

MDL Number:: MFCD00070594

MOL File:: 4511-42-6.mol

MSDS File:: SDS

Last updated:2026-01-13 11:21:10

Product description	Number	Pack Size	Price
(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione 98%	367044	25g	$96.7
(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione 98%	367044	100g	$337
L-(-)-Lactide >98.0%(T)	L0115	25g	$93
L-(-)-Lactide >98.0%(T)	L0115	250g	$557
L-(-)-Lactide	L113600	25g	$150
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L-Lactide Properties

Melting point	92-94 °C(lit.)
Boiling point	255°C
Density	1.186±0.06 g/cm3(Predicted)
vapor pressure	0.311Pa at 25℃
refractive index	1.4475
storage temp.	2-8°C
solubility	Soluble in chloroform, and methanol. Slightly soluble in benzene.
form	Solid
color	White to Off-White
optical activity	[α]20/D 285°, c = 1 in toluene
Water Solubility	16.7g/L at 20℃
Sensitive	Moisture Sensitive
BRN	82124
Stability	Hygroscopic
InChI	1S/C6H8O4/c1-3-5(7)10-4(2)6(8)9-3/h3-4H,1-2H3/t3-,4-/m0/s1
InChIKey	JJTUDXZGHPGLLC-IMJSIDKUSA-N
SMILES	C[C@@H]1OC(=O)[C@H](C)OC1=O
LogP	0.4 at 25℃
CAS DataBase Reference	4511-42-6(CAS DataBase Reference)
FDA UNII	IJ13TO4NO1
EPA Substance Registry System	1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)- (4511-42-6)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38-36

Safety Statements

26-37/39

WGK Germany

TSCA

TSCA listed

HS Code

29322090

Storage Class

13 - Non Combustible Solids

Hazard Classifications

Eye Irrit. 2

NFPA 704

	1
2		0

L-Lactide price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	367044	(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione 98%	4511-42-6	25g	$96.7	2026-03-19	Buy
Sigma-Aldrich	367044	(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione 98%	4511-42-6	100g	$337	2026-03-19	Buy
TCI Chemical	L0115	L-(-)-Lactide >98.0%(T)	4511-42-6	25g	$93	2026-03-19	Buy
TCI Chemical	L0115	L-(-)-Lactide >98.0%(T)	4511-42-6	250g	$557	2026-03-19	Buy
TRC	L113600	L-(-)-Lactide	4511-42-6	25g	$150	2021-12-16	Buy

Product number	Packaging	Price	Buy
367044	25g	$96.7	Buy
367044	100g	$337	Buy
L0115	25g	$93	Buy
L0115	250g	$557	Buy
L113600	25g	$150	Buy

L-Lactide Chemical Properties,Uses,Production

Description

L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione) is a cyclic lactone that is derived from lactic acid. It has the molecular formula C3H6O2 and is an essential building block for synthesizing polylactic acid (PLA) plastics, which are widely used in the manufacturing industry.

Chemical Properties

White crystal

Uses

(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione may be used in the synthesis of optically active terpyridine containing poly(L-lactide)s, polydisperse lactic acid oligomers, bicyclic and tricyclic lactide derivatives.

Application

L-Lactide is a monomer used to produce polylactic acid (PLA), which is a biodegradable thermoplastic that has many uses in the pharmaceutical industry. Additionally, L-Lactide can be used to modify existing drug carriers or create new ones from scratch. As such, the pharmaceutical industry relies heavily on L-Lactide for its versatile applications.

Flammability and Explosibility

Non flammable

Synthesis

L-Lactide is a cyclic molecule obtained from L-lactic acid by a dehydration condensation reaction.

Purification Methods

This is the cyclic dilactone of lactic acid. The (±)-cis-racemate has been distilled with b 142o/8mm; the distillate which solidifies gives yellow needles on recrystallisation from EtOH with m 128o, from Et2O with m 129o, or CHCl3 with m 126o , 1720-1740 cm-1. It hydrolyses in cold max H2O. [Carothers et al. J Am Chem Soc 54 772 1932]. A trans-form (probably RS,SR) has been reported which crystallises from Et2O with m 42-43o [Hummel et al. Acta Cryst (Sect B) 38 1679 1982]. The R,R -(+)-lactide has b 150o/2mm and crystallises from Et2O with m 95o , or m 96.5 -97.5o (from CHCl3) or m 97.7o (from EtOAc) and [] D +297o (c 1.2, *C6H6). The S,S-(-)-lactide has b 150o/2.5mm and crystallises from EtOAc with m 98.7o, or m 95o (from CHCl3) or m 96.5-97.5o (from CCl4) and []D -297o (c 1.2, *C6H6). [Toniolo et al. J Org Chem 35 6 1970, Beilstein 19 H 154, 19 I 179, 19 II 176, 19 IV 1927, 19/5 V 10.]

L-Lactide synthesis

Synthesis of L-Lactide from L(+)-Lactic acid

L-Lactide Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl lactate Butyl lactate

L-Lactide Suppliers

Global( 345)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3590	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Hebei Fengjia New Material Co., Ltd	+86-0311-87836622 +86-18712993135	sales01@tairunfaz.com	China	8051	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Hebei Longbang Technology Co., LTD	+86-18633929156	admin@hblongbang.com	China	972	58
HebeiShuoshengImportandExportco.,Ltd	+86-18532138899	L18532138899@163.com	China	939	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Fengjia New Material Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Jingbo New Material Technology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Longbang Technology Co., LTD	58
HebeiShuoshengImportandExportco.,Ltd	58

Sustainable Pathways for L-Lactide Production
L-Lactide, a cyclic ester and key intermediate for poly(lactic acid)synthesis, is costly due to its complex production involvi....
Apr 23，2025

View Lastest Price from L-Lactide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-12	L-Lactide 4511-42-6	US $20.00-5.00 / KG	1KG	99%	200000KG	Shaanxi Dideu Medichem Co. Ltd
2025-12-01	L-Lactide 4511-42-6	US $0.00-0.00 / KG	1KG	98	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-09-25	L-Lactide 4511-42-6	US $50.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

L-Lactide
4511-42-6
US $20.00-5.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

L-Lactide
4511-42-6
US $0.00-0.00 / KG
98
Shaanxi Dideu New Materials Co. Ltd

L-Lactide
4511-42-6
US $50.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

L-Lactide Spectrum

L-Lactide(4511-42-6)MS L-Lactide(4511-42-6)¹HNMR L-Lactide(4511-42-6)¹³CNMR L-Lactide(4511-42-6)IR1

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L-3,6-Dimethyl-1,4-dioxane-2,5-dione 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)- 3,6-dimethyl-1,4-dioxane-2,5-quinone actide L-(-)-LACTIDE 98+% 3,6-Dimethyl-2,5-p-dioxanedione L-(-)-Lactide ,99% L,L-Dilactide L-3,6-DiMethyl-p-dioxane-2,5-dione LL-Lactide L-(-)-Dilactide (3S,6S)-(-)-3,6-Dimethyl-1,4-dioxane-2,5-dione L(-)-Lactide USP (3S)-cis-3,6-DiMethyl-1,4-dioxane-2,5-dione 98% L-(-)-Lactide (3S,6S) (3S)-CIS-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE (3S,6S)-(-)-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE L-LACTIDE S L-(-)-LACTIDE L-LACTIDE LACTIDE LACTIDE(L-) L-(-)-DILACTIDE PURASORB(R) L 5-dione,3,6-dimethyl-,(3s,6s)-4-dioxane-2 (S,S)-3,6-Dimethyl-1,4-dioxane-2,5-dione L-LA L-(-)-Lactide> L-(-)-Dilactide,99%+ (3S-cis)-3,6-Dimethyl-1,4-dioxan-2,5-dion -(-)-L Biomaterial Intermediate Monomer L-Lactide (LLA) CAS No.:?4511-42-6 L-lactide/L-lactide (with details) Aaron chemistry (3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione 6-Dimethyl-1,4-dioxane-2,5-dione (3S,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione - [D86769] 4511-42-6 4551-42-6 96-96-5 Asymmetric Synthesis Glycidyl Compounds, etc. (Chiral) Lactones & Lactides (for High-Performance Polymer Research) Dioxanes Chiral Building Blocks Dioxanes & Dioxolanes Reagent for High-Performance Polymer Research Organic Building Blocks Lactones Chiral Building Blocks Dioxanes Dioxanes & Dioxolanes Functional Materials Glycidyl Compounds, etc. (Chiral) Lactones & Lactides (for High-Performance Polymer Research) Reagent for High-Performance Polymer Research Synthetic Organic Chemistry 4511-42-6