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Buprofezin

Buprofezin structure

CAS No.: 69327-76-0

Chemical Name:: Buprofezin

Synonyms: BUTYL;BUPROFENZIN;Buprofezine;PP618;Aproad;Appland;NNI 750;VIAPPLA;APPLAUD;BUPROLEX

CBNumber:: CB4436924

Molecular Formula:: C16H23N3OS

Molecular Weight:: 305.44

MDL Number:: MFCD01681899

MOL File:: 69327-76-0.mol

MSDS File:: SDS

Last updated:2026-04-16 19:33:17

Product description	Number	Pack Size	Price
Buprofezin certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland	CRM69368	100 mg	$148
Buprofezin PESTANAL?, analytical standard	37886	100mg	$118
Buprofezin	B5952	5G	$109
Buprofezin	B5952	25G	$326
Buprofezin ≥95%	24137	50mg	$33
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Buprofezin Properties

Melting point	104-106°C
alpha	22 º (c=8,6N HCl)
Boiling point	273°C (12 torr)
Density	1.18
vapor pressure	1.25 x l0^-3 Pa (25 °C)
refractive index	1.52-1.522
Flash point	176-178°C
storage temp.	0-6°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	3.02±0.20(Predicted)
form	Solid
color	White to Pale Beige
Water Solubility	0.9 mg/L at 20 ºC
Decomposition	176-178 ºC
BRN	8324923
Henry's Law Constant	2.4×10⁰ mol/(m³Pa) at 25℃, Duchowicz et al. (2020)
Major Application	agriculture environmental
InChI	1S/C16H23N3OS/c1-12(2)19-14(17-16(3,4)5)21-11-18(15(19)20)13-9-7-6-8-10-13/h6-10,12H,11H2,1-5H3/b17-14+
InChIKey	PRLVTUNWOQKEAI-SAPNQHFASA-N
SMILES	CC(C)N1C(=O)N(CS\C1=N\C(C)(C)C)c2ccccc2
FDA 21 CFR	175.300
CAS DataBase Reference	69327-76-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	3B8KGI239I
NIST Chemistry Reference	4H-1,3,5-thiadiazin-4-one, 2-((1,1-dimethylethyl)imino)tetrahydro-3-(1-methylethyl)-5-phenyl-(69327-76-0)
Pesticides Freedom of Information Act (FOIA)	Buprofezin
EPA Substance Registry System	Buprofezin (69327-76-0)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS09
Signal word	Warning
Hazard statements	H373-H410
Precautionary statements	P260-P273-P314-P391-P501
PPE	Eyeshields, Gloves, type N95 (US)
RIDADR	UN3077(solid)
WGK Germany	2
RTECS	XI2865000
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Acute 1 Aquatic Chronic 1 STOT RE 2
Hazardous Substances Data	69327-76-0(Hazardous Substances Data)
Toxicity	LD50 in mice, rats (mg/kg): 10000, 8740 orally; LC50 (48 hr) in carp: 2-10 mg/l (Kanno, 1981)

Buprofezin price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CRM69368	Buprofezin certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland	69327-76-0	100 mg	$148	2026-03-19	Buy
Sigma-Aldrich	37886	Buprofezin PESTANAL?, analytical standard	69327-76-0	100mg	$118	2026-03-19	Buy
TCI Chemical	B5952	Buprofezin	69327-76-0	5G	$109	2026-03-19	Buy
TCI Chemical	B5952	Buprofezin	69327-76-0	25G	$326	2026-03-19	Buy
Cayman Chemical	24137	Buprofezin ≥95%	69327-76-0	50mg	$33	2024-03-01	Buy

Product number	Packaging	Price	Buy
CRM69368	100 mg	$148	Buy
37886	100mg	$118	Buy
B5952	5G	$109	Buy
B5952	25G	$326	Buy
24137	50mg	$33	Buy

Buprofezin Chemical Properties,Uses,Production

Uses

Buprofezin is a insecticide which works as a chitin synthesis inhibitor. Buprofezin is used to control stubborn rice pests and is effective in controlling green leaf hoppers and white back plant hoppe rs for long durations.

Uses

Insecticide.

Uses

Buprofezin is a contact and ingested insecticide, active against Homoptera (whiteflies, leafhoppers, scale insects, etc.) in and on citrus, cotton, cucumbers, tomatoes, sweet potatoes, rice, etc.

Definition

ChEBI: Buprofezin is a 2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one in which the C=N double bond has Z configuration. It has a role as an insecticide and a member of homopteran inhibitor of chitin biosynthesis.

Hazard

Moderately toxic by ingestion. Low toxic- ity by skin contact.

Agricultural Uses

Insecticide, Acaricide, Insect growth regulator: For insect control in food crops and greenhouse ornamentals.

Trade name

APPLAUD®; NNI-750®

Pharmacology

The foregoing indicates that the modes of action of buprofezin and benzoylureas could be similar or identical. However, one differing biochemical effect of buprofezin is inhibition of prostaglandin biosynthesis (33), a mechanism that has been suggested as responsible for its ovicidal activity. Subsequently, the in vitro and in vivo effects of buprofezin were found to be strongly antagonized by 20- hydroxyecdysone (34), which also affected prostaglandin biosynthesis. Thus, inhibition of both prostaglandin and chitin biosynthesis by buprofezin was prevented by 20- hydroxyecdysone, so that both effects of the insecticide are mediated via an effect on the hormone concentration or its receptor. Consequently, buprofezin seems to inhibit the drop in the 20-hydroxyecdysone titer that triggers epidermal cell proliferation, old cuticle digestion, and new cuticle deposition, but the detailed mechanism of this action has yet to be established.

Metabolic pathway

Buprofezin gradually decomposes in soils under flooded and upland conditions, with half-lives of 104 and 80 days, respectively. After 150 days, five degradation products are identified as 2-tert- butylimino-5-(4-hydroxyphenyl)-3-isopropylperhydro- 1,3,5-thiadiazin-4-one, 3-isopropyl-5-phenylperhydro- 1,3,5-thiadiazin-2,4-dione, 1-tert-butyl-3-ispropyl-5- phenylbiuret, 1-isopropyl-3-phenylurea, and phenylurea. As minor products, 2-tert-butylimino-5- phenylperhydro-1,3,5-thiadiazin-4-one or buprofezin sulfoxide are found in the flooded or in the upland soils. Since neither formation of 14CO2 nor hydroxylation is observed in the sterile soils, buprofezin seems to have undergone complete mineralization in soils under both conditions through biological transformation by soil microorganisms.

Degradation

Buprofezin (1) was degraded under acidic conditions with half-lives (DT₅₀) f 6-12 days (pH 4), 34 days (pH 6) and 65 days (pH 10) at 40 °C. Opening of the thiadiazinanone ring appeared to be the primary hydrolytic degradation pathway, to yield 1-tert-butyl-3-isopropyl-5-phenyl-2- thiobiuret (2) and N-isopropyl-N-phenylurea (3) as major products.
Buprofezin is stable to aqueous photolysis. The estimated DT₅₀ of buprofezin in distilled water when exposed to UV light was 39 days. A more complex photodegradation pathway of buprofezin in methanol was reported recently (Datta and Walia, 1997) with DT9 values of 4 hours and 15 days under UV and sunlight irradiation, respectively.

Buprofezin Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid N-T-BUTYL-N'-ISOPROPYLTHIOUREA ISOPROPYLTHIOUREA N-Methylaniline N-Chloromethyl-N-phenylaminoformyl chloride

Toluene Chlorine Formic acid tert-Butanol Ammonium thiocyanate

Carbon tetrachloride PHOSGENE 3-Methyl-1-butanol Isopropylamine Butyl isothiocyanate

N-Methylformanilide Thiourea

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Preparation Products

Imidacloprid+Buprofenzin,W.P. Buprofezin+Isoprocarb,W.P. Buprofenzin+Monosultap,W.P.

Buprofezin Suppliers

Global( 268)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Qingdao Trust Agri Chemical Co.,Ltd	+86-008615963231493 +86-008613573296305	trustagri@hotmail.com	China	299	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	1497	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58

Supplier	Advantage
Qingdao Trust Agri Chemical Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Xi'an MC Biotech, Co., Ltd.	58

View Lastest Price from Buprofezin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	Buprofezin 69327-76-0	US $0.00 / kg	100kg	98	10000	Qingdao Trust Agri Chemical Co.,Ltd
2026-04-16	Buprofezin 69327-76-0	US $46.00-107.00 / mg		99.73%	10g	TargetMol Chemicals Inc.
2021-08-10	Buprofezin 69327-76-0	US $40.00 / KG	1KG	99	10 tons	Shijiazhuang tongyang Import and Export Co., LTD

Buprofezin
69327-76-0
US $0.00 / kg
98
Qingdao Trust Agri Chemical Co.,Ltd

Buprofezin
69327-76-0
US $46.00-107.00 / mg
99.73%
TargetMol Chemicals Inc.

Buprofezin
69327-76-0
US $40.00 / KG
99
Shijiazhuang tongyang Import and Export Co., LTD

Buprofezin Spectrum

Buprofezin(69327-76-0)MS Buprofezin(69327-76-0)¹HNMR Buprofezin(69327-76-0)¹³CNMR Buprofezin(69327-76-0)IR1 Buprofezin(69327-76-0)IR2

69327-76-0(Buprofezin)Related Search:

Isopropyl acetate Phenylhydrazine PHENYL VALERATE Lithium diisopropylamide 4-tert-Butylbenzyl chloride

2-Chloro-2-methylpropane 3,4'-DIAMINODIPHENYLMETHANE ISOPROPYL LAURATE Acetamiprid Imidacloprid

Isopropyl alcohol tert-Butyldimethylsilyl chloride DI-TERT-BUTYL ETHER Chlormezanone Isoprocarb

BROMOPYRAZONE N'-TERT-BUTYL-N,N-DIMETHYLFORMAMIDINE Buprofezin

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3,5-Thiadiazin-4-one,2-[(1,1-dimethylethyl)imino]tetrahydro-3-(1-methylethyl)-5-phenyl-4H-1 4H-1,3,5-Thiadiazin-4-one, 2-((1,1-dimethylethyl)imino)tetrahydro-3-(1-methylethyl)-5-phenyl- 4h-1,3,5-thiadiazin-4-one,2-((1,1-dimethylethyl)imino)tetrahydro-3-(1-methylet Appland Aproad buprofenzin,w.p. Buprofezine NNI 750 2-tert-Butylimino-3-isopropyl-5-phenyl-3,4,5,6-tetrahydro-2H-1,3,5-thiodiazin-4-one 2-tert-Butylimino-3-isopropyl-5-phenylperhydro-1,3,5-thiadiazinan-4-one (2Z)-2-([(Z)-1,1-Dimethylethyl]imino)-3-isopropyl-5-phenyl-1,3,5-thiadiazinan-4-one 2-((1,1-dimethylethyl)imino)tetrahydro-3-(1-methylethyl)-5-phenyl-4h-1,3,5-t 2-tert-Butylimino-3-isopropyl-5-phenyl-1,3,5-thiadiazinan-4-one 2-tert-Butylimino-3-isopropyl-5-phenyl-3,4,5,6-tetrahydro-2H-1,3,5-thiadiazin-4-one Burprofezin hiadiazin-4-one 2-tert-buthylimino-3-iso-propyl-5-phenyl-3,4,5,6-tetraphydro-2H-1,3,5-thiadiaziana-4-one 2-tert-Butylimino-3-isopropyl-5-phenyl-2,3,5,6-tetrahydro-4H-1,3,5-thiadiazin-4-one 2-tert-Butyliminotetrahydro-3-isopropyl-5-phenyl-4H-1,3,5-thiadiazin-4-one 2-T-BUTYLIMINO-3-ISOPROPYL-5-PHENYLPERHYDRO-1,3,5-THIADIAZINAM-4-ONE 2-((1,1-Dimethylethyl)imino)tetrahydro-3-(1-methylethyl)-5-phenyl-4H-1,3,5-thiadiazin-4-one 2-(tert-Butylimino)-3-isopropyl-5-phenylperhydro-1,3,5-thidiazin-4-one Buprofezin 100mg [69327-76-0] BUPROFEZINSTANDARD (Z)-2-(tert-butylimino)-5-(4-hydroxyphenyl)-3-isopropyl-1,3,5-thiadiazinan-4-one (Z)-buprofezin 2-tert-butylimino-5-(4-hydroxyphenyl)-3-propan-2-yl-1,3,5-thiadiazinan-4-one VIAPPLA hyl)-5-phenyl- PP618 BUTYL BUPROFENZIN BUPROFEZIN BUPROLEX APPLAUD APPLAUD(R) 2-((1,1-dimethylethyl)imino)tetrahydro-3-(1-methylethyl)-5-phenyl-4h-1,3,5-thiadiazin-4-one 2-(tert-Butylimino)-3-isopropyl-5-phenylperhydro-1,3,5-thidiazin-4-one 2-TERT-BUTYLAMINO-3-ISOPROPYL-5-PHENYL-1,3,5-THIADIAZINAN-4-ONE MARATHON BUPROFEZIN PESTANAL BUPROFEZIN, 100MG, NEAT 2-tert-Butylimino-3-isopropyl-5-phenylperhydro-1,3,5-thiadiazin-4-one 2-tert.-Butylimino-3-isopropyl-5-phenylperhydro-1,3,5-thiodiazin-4-one buprofezin (bsi,iso) Buprofezin@1000 μg/mL in Acetone Buprofezin @100 μg/mL in Methanol BuprofezinSolution,1,000mg/L,1ml Buprofezin Reference Material BuprofezinSolution,100mg/L,1ml Buprofezin 25%SC Insecticides for Rice potatoes citrus CAS No 69327-76-0 (EZ)-Buprofezin Mitotane-13C Buprofezin Solution in Methanol Buprofezin in Acetone Buprofezin in Methanol Buprofezin 10 μg/ml Ethyl acetate Buprofezin 100 μg/ml Acetonitrile Buprofezin 100 μg/ml Ethyl acetate