TRIMETHYLTIN HYDROXIDE
- CAS No.
- 56-24-6
- Chemical Name:
- TRIMETHYLTIN HYDROXIDE
- Synonyms
- trimethylstannanol;trimethylstannylhydroxide;TRIMETHYLTIN(IV) HYDROXIDE;hydroxytrimethylstannane;Me3SnOH;trimethylhydroxytin;hydroxytrimethyltin;hydroxytrimethyl-ti;rimethyltin,hydrate;trimethyl-tihydroxide
- CBNumber:
- CB4440435
- Molecular Formula:
- C3H10OSn
- Molecular Weight:
- 180.82
- MDL Number:
- MFCD00013929
- MOL File:
- 56-24-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Trimethylstannanol AldrichCPR | CDS025240 | 100MG | $103 |
| Trimethyltin hydroxide, 98% | 93-5085 | 2g | $94 |
| Trimethyltin hydroxide, 98% | 93-5085 | 10g | $375 |
| Trimethyltin hydroxide, 98% | 93-5085 | 50g | $1512 |
| TrimethyltinHydroxide | T797615 | 500mg | $115 |
| Melting point | 118°C |
|---|---|
| Boiling point | 80°C |
| RTECS | WH8400000 |
| Flash point | 26℃ |
| solubility | Chloroform (Soluble, Sonicated), Methanol (Slightly, Sonicated), Water (Sparingly) |
| form | Powder |
| pka | 6.36±0.70(Predicted) |
| color | White |
| Water Solubility | Soluble in water. |
| Sensitive | Moisture Sensitive |
| Exposure limits |
ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin) NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3 |
| InChI | InChI=1S/3CH3.H2O.Sn/h3*1H3;1H2;/q;;;;+1/p-1 |
| InChIKey | OJZNYUDKNVNEMV-UHFFFAOYSA-M |
| SMILES | [Sn](O)(C)(C)C |
| FDA UNII | 10ALT8DJ2V |
| EPA Substance Registry System | Stannane, hydroxytrimethyl- (56-24-6) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H310-H330-H400-H410 | |||||||||
| Precautionary statements | P301+P310a-P304+P340-P320-P330-P405-P501a | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | 3146 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 1 Dermal Acute Tox. 2 Inhalation Acute Tox. 2 Oral Aquatic Acute 1 Aquatic Chronic 1 |
|||||||||
| NFPA 704 |
|
TRIMETHYLTIN HYDROXIDE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS025240 | Trimethylstannanol AldrichCPR | 56-24-6 | 100MG | $103 | 2025-07-31 | Buy |
| Strem Chemicals | 93-5085 | Trimethyltin hydroxide, 98% | 56-24-6 | 2g | $94 | 2024-03-01 | Buy |
| Strem Chemicals | 93-5085 | Trimethyltin hydroxide, 98% | 56-24-6 | 10g | $375 | 2024-03-01 | Buy |
| Strem Chemicals | 93-5085 | Trimethyltin hydroxide, 98% | 56-24-6 | 50g | $1512 | 2024-03-01 | Buy |
| TRC | T797615 | TrimethyltinHydroxide | 56-24-6 | 500mg | $115 | 2021-12-16 | Buy |
TRIMETHYLTIN HYDROXIDE Chemical Properties,Uses,Production
Chemical Properties
Trimethyltin hydroxide is a colorless, white crystals. It is soluble in water and many organic solvents. It is commercially available in the form of large, needle-shaped, crystals with a significant propensity for twinning along the needle axis. The twinning of the trimethyltin hydroxide needle shaped crystals makes finding a single crystal for data collection very difficult.
Uses
Trimethyltin hydroxide is used in the synthesis of modified thymines, which is useful as inhibitors of RNase A. It is also used in the preparation of ketoheterocycle inhibitors of fatty acid amide inhibitors. It reacts with 2,2-disubstituted benzothiazolines to form trialkyltin derivatives of sulphur containing Schiff base complexes.
Reactions
The synthesis of N-Boc-N-(2-(tritylthio)ethoxy)glycine (4) is illustrated in Scheme 2. O-(2-(tritylthio)ethyl)hydroxylamine (1) was synthesized using the literature method. The aminooxy group was then protected with Boc, followed by alkylation with methyl bromoacetate in the presence of sodium hydride. Saponification of the methyl ester with trimethyltin hydroxide afforded N-Boc-N-(2-(tritylthio)ethoxy)glycine (4) in an overall yield of 19% after three steps of reactions. The Boc and Trt protecting groups in building block 4 are stable to Fmoc SPPS and are readily removable by treatment with trifluoroacetic acid (TFA).
Hazard
A poison.
References
[1] Anderson, Kirsty M., et al. "Trimethyltin hydroxide: a crystallographic and high Z′ curiosity." Crystal Growth & Design, 2011, 11 3: 820-826. DOI:10.1021/cg101464j.
[2] K. C. NICOLAOU PROF. DR. A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide[J]. Angewandte Chemie International Edition, 2005, 44 9: 1378-1382. DOI:10.1002/anie.200462207.
[3] ROBIN K HARRIS Patrick R Kenneth J Packer. High-resolution Tin-119 NMR of solid trimethyltin hydroxide[J]. Journal of Magnetic Resonance (1969), 1985, 61 3: Pages 564-566. DOI:10.1016/0022-2364(85)90199-4.
[4] LINGLING PENG, AIMIN SONG* N-tert-Butoxycarbonyl-N-(2-(tritylthio)ethoxy)glycine as a Building Block for Peptide Ubiquitination[J]. Bioconjugate Chemistry Bioconjugate, 2024, 35 2: 245-253. DOI:10.1021/acs.bioconjchem.3c00541.
TRIMETHYLTIN HYDROXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
TRIMETHYLTIN HYDROXIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3986 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53807 | 58 |
| Hangzhou Collab Medicine Co.,Ltd. | +8615936229464 | candice@collab-med.com | China | 995 | 58 |
| Chongqing jooe co., ltd | +undefined86-15223382610 | info@jooe.com | China | 15976 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Domole Scientific | 13275595566 | domole@infsci.com | China | 300 | 58 |
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