Methyl 2,5-dihydroxybenzoate
- CAS No.
- 2150-46-1
- Chemical Name:
- Methyl 2,5-dihydroxybenzoate
- Synonyms
- METHYL GENTISATE;RARECHEM AL BF 0043;TIMTEC-BB SBB007711;2,5-hydroxybenzoate;Gentisic acid methyl;Methyl 2,5-Dihydroxyben;METHYL DIHYDROXYBENZOATE;GENTISIC ACID METHYL ESTER;METHYL 3,6-DIHYDROXYBENZOATE;METHYL 2,5-DIHYDROXYBENZOATE
- CBNumber:
- CB4444024
- Molecular Formula:
- C8H8O4
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD00016464
- MOL File:
- 2150-46-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2,5-dihydroxybenzoate 99% | 426091 | 25g | $256 |
| Methyl 2,5-Dihydroxybenzoate >98.0%(GC)(T) | M2006 | 5g | $38 |
| Methyl 2,5-Dihydroxybenzoate >98.0%(GC)(T) | M2006 | 25g | $149 |
| Methyl 2,5-dihydroxybenzoate | M301900 | 5g | $55 |
| Methyl 2,5-dihydroxybenzoate | J50585 | 100g | $74 |
| More product size | |||
| Melting point | 86-88 °C (lit.) |
|---|---|
| Boiling point | 136 °C / 1mmHg |
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.87±0.18(Predicted) |
| form | Solid |
| color | Off-White to Pale Beige |
| Stability | Hygroscopic |
| Cosmetics Ingredients Functions | CHELATING |
| InChI | InChI=1S/C8H8O4/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4,9-10H,1H3 |
| InChIKey | XGDPKUKRQHHZTH-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC(O)=CC=C1O |
| LogP | 1.830 (est) |
| CAS DataBase Reference | 2150-46-1(CAS DataBase Reference) |
| FDA UNII | LS28B004KM |
| NIST Chemistry Reference | Benzoic acid, 2,5-dihydroxy-, methyl ester(2150-46-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29182900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 2,5-dihydroxybenzoate price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 426091 | Methyl 2,5-dihydroxybenzoate 99% | 2150-46-1 | 25g | $256 | 2025-07-31 | Buy |
| TCI Chemical | M2006 | Methyl 2,5-Dihydroxybenzoate >98.0%(GC)(T) | 2150-46-1 | 5g | $38 | 2025-07-31 | Buy |
| TCI Chemical | M2006 | Methyl 2,5-Dihydroxybenzoate >98.0%(GC)(T) | 2150-46-1 | 25g | $149 | 2025-07-31 | Buy |
| TRC | M301900 | Methyl 2,5-dihydroxybenzoate | 2150-46-1 | 5g | $55 | 2021-12-16 | Buy |
| AK Scientific | J50585 | Methyl 2,5-dihydroxybenzoate | 2150-46-1 | 100g | $74 | 2021-12-16 | Buy |
Methyl 2,5-dihydroxybenzoate Chemical Properties,Uses,Production
Uses
methyl gentisate is also known as methyl dihydroxybenzoate. It is a skin-lightening ingredient that acts by inhibiting the melanocyte’s production of tyrosinase. It can be naturally obtained from gentian root.
Uses
Methyl 2,5-dihydroxybenzoate (methyl gentisate) may be used as a starting material in the synthesis of euonyminol.
Definition
ChEBI: Methyl 2,5-dihydroxybenzoate is a member of phenols and a benzoate ester.
General Description
Methyl 2,5-dihydroxybenzoate (methyl gentisate) is an alkyl ester of gentisic acid. It is reported to show less cytotoxic and mutagenic activity than hydroquinone with a potential to inhibit melanogenesis. It has been synthesized from 2,5-dihydroxybenzoic acid. The crystal structure of the molecule was found to be planar.
Synthesis
67-56-1
490-79-9
2150-46-1
2,5-Dihydroxybenzoic acid (5.00 g, 32.5 mmol) was dissolved in methanol (33 mL) and concentrated sulfuric acid (5 mL) was added slowly and dropwise. The reaction mixture was heated under reflux conditions for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed under vacuum. The residue was neutralized with saturated aqueous NaHCO3 to pH 7. Subsequently, the product was extracted with ethyl acetate (50 mL x 3), the organic layers were combined, washed with brine (20 mL), dried over anhydrous MgSO4, filtered and the filtrate was evaporated to give the light brown powdery product methyl 2,5-dihydroxybenzoate (5.13 g, 94% yield). The structure of the product was analyzed by 1H NMR (CDCl3) δ 10.35 (s,1H), 7.29 (d, J = 3.2 Hz, 1H), 7.02 (dd, J = 8.7,3.2 Hz, 1H), 6.89 (d, J = 8.7 Hz, 1H), 4.69 (s,1H), 3.95 (s,1H); 13C NMR (CDCl3) δ 170.1,155.8,147.6,124.0,118.5,114.7,112.1,52.4; HRMS (ESI):[M-H]- Calculated value of C8H7O4 167.0344, confirmed by measured value of 167.0359.
References
[1] Organic Letters, 2009, vol. 11, # 6, p. 1201 - 1204
[2] Journal of the American Chemical Society, 2010, vol. 132, # 16, p. 5869 - 5879
[3] Journal of Organic Chemistry, 2018, vol. 83, # 3, p. 1116 - 1133
[4] European Journal of Organic Chemistry, 2003, # 15, p. 2840 - 2844
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6321 - 6325
Methyl 2,5-dihydroxybenzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Xi an Biohorlden Industry Trade Co Ltd | +86-18829283179 +86-13636819721 | sales@horlden.com | China | 323 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from Methyl 2,5-dihydroxybenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-07 | Methyl 2,5-dihydroxybenzoate
2150-46-1
|
US $0.00-0.00 / kg | 1kg | 98% | 100 | Xi an Biohorlden Industry Trade Co Ltd | |
 |
2025-05-26 | METHYL DIHYDROXYBENZOATE
2150-46-1
|
US $30.00 / kg | 1kg | 0.99 | 100 tons | Hebei Fengjia New Material Co., Ltd | |
 |
2021-11-02 | Methyl 2,5-dihydroxybenzoate
2150-46-1
|
US $191.00 / KG | 1KG | 99 | 10T | Baoji Guokang Healthchem co.,ltd |
-
- Methyl 2,5-dihydroxybenzoate
2150-46-1
- US $0.00-0.00 / kg
- 98%
- Xi an Biohorlden Industry Trade Co Ltd
-
- METHYL DIHYDROXYBENZOATE
2150-46-1
- US $30.00 / kg
- 0.99
- Hebei Fengjia New Material Co., Ltd
-
- Methyl 2,5-dihydroxybenzoate
2150-46-1
- US $191.00 / KG
- 99
- Baoji Guokang Healthchem co.,ltd
