SB408124
- CAS No.
- 288150-92-5
- Chemical Name:
- SB408124
- Synonyms
- CS-1990;SB 408124;SB 408214;SB408124 ，S1545;SB408124 USP/EP/BP;SB 408124; SB408124;SB-408124, CID4331799;SB-408124, 10 mM in DMSO;SB-408124 >=98% (HPLC), solid;SB 408124, non-peptide OX1 antagonist
- CBNumber:
- CB4445874
- Molecular Formula:
- C19H18F2N4O
- Molecular Weight:
- 356.37
- MDL Number:
- MFCD06411575
- MOL File:
- 288150-92-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| SB-408124 ≥98% (HPLC), solid | S2694 | 5mg | $149.1 |
| SB-408124 ≥98% (HPLC), solid | S2694 | 25mg | $581 |
| SB-408124 ≥98% | 22961 | 5mg | $81 |
| SB-408124 ≥98% | 22961 | 10mg | $143 |
| SB-408124 ≥98% | 22961 | 25mg | $317 |
| More product size | |||
| Boiling point | 430.3±45.0 °C(Predicted) |
|---|---|
| Density | 1.371 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ~24 mg/mL |
| form | solid |
| pka | 12.12±0.43(Predicted) |
| color | olive-green |
| FDA UNII | C3YT74C744 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SB408124 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S2694 | SB-408124 ≥98% (HPLC), solid | 288150-92-5 | 5mg | $149.1 | 2025-07-31 | Buy |
| Sigma-Aldrich | S2694 | SB-408124 ≥98% (HPLC), solid | 288150-92-5 | 25mg | $581 | 2025-07-31 | Buy |
| Cayman Chemical | 22961 | SB-408124 ≥98% | 288150-92-5 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 22961 | SB-408124 ≥98% | 288150-92-5 | 10mg | $143 | 2024-03-01 | Buy |
| Cayman Chemical | 22961 | SB-408124 ≥98% | 288150-92-5 | 25mg | $317 | 2024-03-01 | Buy |
SB408124 Chemical Properties,Uses,Production
Uses
SB 408124 is a novel OX-1 antagonist.
Definition
ChEBI: 1-(6,8-difluoro-2-methyl-4-quinolinyl)-3-[4-(dimethylamino)phenyl]urea is a member of quinolines and an organohalogen compound.
Biological Activity
Selective non-peptide orexin OX 1 receptor antagonist (K b values are 21.7 and 1405 nM for human OX 1 and OX 2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo .
in vivo
SB-408124 (30 μg/10 μl; i.c.v.; male Wistar rats) decreases Orexin-A induced water intake in Wistar rats[2].
IC 50
OX1 Receptor: 57 nM (Ki, in whole cell ); OX1 Receptor: 27 nM (Ki, in cell membrane)
storage
Store at RT
References
[1] langmead cj1, jerman jc, brough sj, scott c, porter ra, herdon hj.characterisation of the binding of [3h]-sb-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. br j pharmacol. 2004 jan;141(2):340-6.
[2] woldan-tambor a1, biegańska k, wiktorowska-owczarek a, zawilska jb. activation of orexin/hypocretin type 1 receptors stimulates camp synthesis in primary cultures of rat astrocytes. pharmacol rep. 2011;63(3):717-23.
[3] kis gk1, molnár ah, daruka l, gardi j, rákosi k, lászló f, lászló fa, varga c.the osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. pflugers arch. 2012 apr;463(4):531-6.
SB408124 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20292 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39032 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
