ChemicalBook >> CAS DataBase List >>8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one structure

CAS No.: 31251-41-9

Chemical Name:: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Synonyms: Loratadine Related CoMpound C;Loratadine impurity B;8-Chloro-10;Keto loratadine;Loratad Impurity B;2-b]pyridin-11-one;D] cycloheptan-5-one;6-dihydro-11H-benzo[5;Loratadine tricycline;Loratadine EP IMpurity B

CBNumber:: CB4456713

Molecular Formula:: C14H10ClNO

Molecular Weight:: 243.69

MDL Number:: MFCD00800222

MOL File:: 31251-41-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:19:42

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8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Properties

Melting point	90-92°C
Boiling point	433.6±45.0 °C(Predicted)
Density	1.313±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	3.14±0.20(Predicted)
color	Pale Yellow to Pale Brown
Major Application	pharmaceutical
InChI	InChI=1S/C14H10ClNO/c15-11-5-6-12-10(8-11)4-3-9-2-1-7-16-13(9)14(12)17/h1-2,5-8H,3-4H2
InChIKey	WMQNOYVVLMIZDV-UHFFFAOYSA-N
SMILES	C12C(=O)C3=CC=C(Cl)C=C3CCC1=CC=CN=2
CAS DataBase Reference	31251-41-9(CAS DataBase Reference)
FDA UNII	Y8MA5G8500
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes	Xi
WGK Germany	WGK 3
HS Code	2933997500
Storage Class	11 - Combustible Solids
REACH Registrations	Active

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2309	Loratadine Related Compound C Pharmaceutical Secondary Standard; Certified Reference Standard	31251-41-9	50MG	$707	2026-04-30	Buy
Sigma-Aldrich	1370269	Loratadine Related Compound C United States Pharmacopeia (USP) Reference Standard	31251-41-9	15mg	$1340	2026-04-30	Buy
TCI Chemical	C3181	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one >98.0%(GC)(T)	31251-41-9	5g	$155	2026-04-30	Buy
TCI Chemical	C3181	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one >98.0%(GC)(T)	31251-41-9	25g	$387	2026-04-30	Buy
TRC	TRC-C365245-500MG	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one >95%(HPLC)	31251-41-9	500mg	$200	2026-06-03	Buy

Product number	Packaging	Price	Buy
PHR2309	50MG	$707	Buy
1370269	15mg	$1340	Buy
C3181	5g	$155	Buy
C3181	25g	$387	Buy
TRC-C365245-500MG	500mg	$200	Buy

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine EP Impurity B; Loratadine USP Related Compound C) is a Loratadine intermediate. Loratidine impurity C.

Synthesis

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

31255-57-9

31251-41-9

General procedure for the synthesis of 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one from 3-(3-chlorophenylethyl)pyridine-2-carbonitrile: 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (10 g) obtained in step C was dissolved in trifluorosulfonic acid (80 ml) and the reaction was stirred at 60 °C for 1 hour. Subsequently, aqueous 6N hydrochloric acid (80 ml) was added slowly and dropwise at room temperature. The reaction mixture was refluxed for 1 hour and poured into ice water. The reaction solution was neutralized with 50% aqueous sodium hydroxide, the precipitate precipitated was separated, washed with water and recrystallized by solvent mixture of isopropanol/water (3:1) to afford the target product 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one. The mother liquor was concentrated and the residue was washed sequentially with water and chloroform to afford additionally 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (9.4 g, yield 94%).1H NMR (MeOD-d4) δ: 3.3-3.4 (m, 2H), 3.4-3.5 (m, 2H), 7.5 (m, 2H), 8.1-8.2 (m, 2H), 8.7 (d, 1H), 8.9 (d, 1H).

References

[1] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 56-57
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 6, p. 1778 - 1782
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 457 - 461

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one synthesis

Synthesis of 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one from 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Preparation Products And Raw materials

Raw materials

2-Pyridinecarboxamide, 3-[2-(5-chloro-2-iodophenyl)ethyl]-N-methyl-N-phenyl- 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile N-phenyl-3-[2-(3-chlorophenyl)ethyl]-2-pyridine carboxamide Carbon Hydrochloric acid

Preparation Products

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Suppliers

Global( 279)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
UHN Shanghai Research & Development Co., Ltd.	021-58958002 18930822973	sales@uhnshanghai.com	China	997	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57

Supplier	Advantage
UHN Shanghai Research & Development Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Chemsky（shanghai）International Co.,Ltd.	50
Sichuan Kulinan Technology Co., Ltd	57

View Lastest Price from 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-11	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 31251-41-9		1KG	99%	100KGS	WUHAN FORTUNA CHEMICAL CO., LTD
	2019-12-26	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 31251-41-9	$1.00	1KG	99%	100kg	Career Henan Chemical Co

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9
99%
WUHAN FORTUNA CHEMICAL CO., LTD

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9
$1.00
99%
Career Henan Chemical Co

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Spectrum

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(31251-41-9)¹HNMR 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(31251-41-9)¹³CNMR

31251-41-9(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one)Related Search:

Pyridine hydrobromide Copper Pyrithione 2-Chloro-3-cyanopyridine Zinc pyrithione Benzo[b]thien-2-ylboronic acid

Clopidol Pentachloropyridine Pyridine hydrofluoride 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity) Loratadine Impurity 13 Loratadine Impurity 17 3-Hydroxy loratadine Loratadine Impurity 13

8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol Loratadine Impurity 15 Loratadine EP IMpurity F

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8-CHLORO-5,6-DIHYDRO-11H-BENZO-(5,6)-CYCLOHEPTA-(1,2-B)-PYRIMIDINE-11-ON 8-Chloro-10,11-dihydro-4-aza-5 8-chloro-10,11-dihydro-4-AZA-5H-benzo〔A,D〕cyclohepta-5-one 8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIMIDINE-11-ONE 4-Aza-8-chloro-10,11-dihydro-5H-benzo[a,d]cyclo-5-heptanone 8-CHLORO-10,11-DIHYDRO-4 AZA-5H-BENZO[A,D] CYCLOHEPTAN-5-ONE =98% 8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-ONE 8-CHLORO-10,11-DIHYDRO-4-AZA-5H-DIBENZO-(A,D)CYCLOHEPTAN-5-ONE 8-CHLORO-10,11-DIHYDRO-4-AZA-5H-BENZO[A,D] CYCLOHEPTAN-5-ONE 8-CHLORO-6,11-DIHYDRO-11-(1-METHYL-4-PIPERIDYLEDENE)-5H-BENZO(5,6)-CYCLOHEPTA(1,2,B)PYRIDINE 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one 11-dihydro-4-aza-5H-benzo[A 8-Chloro-10 D] cycloheptan-5-one 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclo hepta[1,2-b]pyridin-11- Loratadine Related Compound C (15 mg) (8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one) Loratadine EP IMpurity B 11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one,8-chloro-5,6-dihydro- 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Keto loratadine Loratadine Impurity 2(Loratadine EP Impurity B) Loratad Impurity B 8-Chloro-5,6-dihydro-11H-benzo[5.6] 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclo- 2-b]pyridin-11-one 6-dihydro-11H-benzo[5 8-Chloro-10,11-dihydro-4-AZA-5H-dibenzo(a,d)- Cyclohepten-5-One(or)(Loraketone) 13-chloro-4-azatricyclo[9.4.0.0,3,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-one 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Desloratadine Impurity) Loratidine EP Impurity B/ Loratidine Related Compound C 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptan-5-on... Loratadine Related Compound C (8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one) (1370269) Loratadine Impurity B（EP ） Loratadine USP Related Compound C 8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo (a,d)ycloheptan-5-one 2-chloromethyl-3-methy1-4-(2,2,2- triflu oroethoxy) pyridine hydrochloride Loratadine tricycline 8-chloro-5,6-dihydro-11H-benzo [5,6] cycloheptano [1,2-b] pyridin-11 one 8-chloro-10,Chemicalbook11-dihydro-4-AZA-5H-benzo〔A,D〕cyclohepta-5-one 13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-one Loratadine EP Impurity B (Loratadine USP Related Compound C) Loratadine Related CoMpound C Loratadine impurity B 31251-41-9 31521-41-9 C14H10ClNO Aromatics Heterocycles Intermediates Aromatics Compounds