ChemicalBook >> CAS DataBase List >>8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one structure

CAS No.: 31251-41-9

Chemical Name:: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Synonyms: 8-Chloro-10;Keto loratadine;Loratad Impurity B;2-b]pyridin-11-one;D] cycloheptan-5-one;Loratadine impurity B;6-dihydro-11H-benzo[5;Loratadine tricycline;Loratadine EP IMpurity B;Loratadine Impurity B（EP ）

CBNumber:: CB4456713

Molecular Formula:: C14H10ClNO

Molecular Weight:: 243.69

MDL Number:: MFCD00800222

MOL File:: 31251-41-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
Loratadine Related Compound C Pharmaceutical Secondary Standard; Certified Reference Standard	PHR2309	50MG	$621.3
Loratadine Related Compound C United States Pharmacopeia (USP) Reference Standard	1370269	15mg	$1250
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one >98.0%(GC)(T)	C3181	5g	$155
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one >98.0%(GC)(T)	C3181	25g	$387
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one	C365245	500mg	$135
More product size

Request For Quotation

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Properties

Melting point	90-92°C
Boiling point	433.6±45.0 °C(Predicted)
Density	1.313±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	3.14±0.20(Predicted)
color	Pale Yellow to Pale Brown
InChI	InChI=1S/C14H10ClNO/c15-11-5-6-12-10(8-11)4-3-9-2-1-7-16-13(9)14(12)17/h1-2,5-8H,3-4H2
InChIKey	WMQNOYVVLMIZDV-UHFFFAOYSA-N
SMILES	C12C(=O)C3=CC=C(Cl)C=C3CCC1=CC=CN=2
CAS DataBase Reference	31251-41-9(CAS DataBase Reference)
FDA UNII	Y8MA5G8500
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes	Xi
HS Code	2933997500

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2309	Loratadine Related Compound C Pharmaceutical Secondary Standard; Certified Reference Standard	31251-41-9	50MG	$621.3	2025-07-31	Buy
Sigma-Aldrich	1370269	Loratadine Related Compound C United States Pharmacopeia (USP) Reference Standard	31251-41-9	15mg	$1250	2025-07-31	Buy
TCI Chemical	C3181	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one >98.0%(GC)(T)	31251-41-9	5g	$155	2025-07-31	Buy
TCI Chemical	C3181	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one >98.0%(GC)(T)	31251-41-9	25g	$387	2025-07-31	Buy
TRC	C365245	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one	31251-41-9	500mg	$135	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHR2309	50MG	$621.3	Buy
1370269	15mg	$1250	Buy
C3181	5g	$155	Buy
C3181	25g	$387	Buy
C365245	500mg	$135	Buy

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine EP Impurity B; Loratadine USP Related Compound C) is a Loratadine intermediate. Loratidine impurity C.

Synthesis

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

31255-57-9

31251-41-9

General procedure for the synthesis of 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one from 3-(3-chlorophenylethyl)pyridine-2-carbonitrile: 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (10 g) obtained in step C was dissolved in trifluorosulfonic acid (80 ml) and the reaction was stirred at 60 °C for 1 hour. Subsequently, aqueous 6N hydrochloric acid (80 ml) was added slowly and dropwise at room temperature. The reaction mixture was refluxed for 1 hour and poured into ice water. The reaction solution was neutralized with 50% aqueous sodium hydroxide, the precipitate precipitated was separated, washed with water and recrystallized by solvent mixture of isopropanol/water (3:1) to afford the target product 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one. The mother liquor was concentrated and the residue was washed sequentially with water and chloroform to afford additionally 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (9.4 g, yield 94%).1H NMR (MeOD-d4) δ: 3.3-3.4 (m, 2H), 3.4-3.5 (m, 2H), 7.5 (m, 2H), 8.1-8.2 (m, 2H), 8.7 (d, 1H), 8.9 (d, 1H).

References

[1] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 56-57
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 6, p. 1778 - 1782
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 457 - 461

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one synthesis

Synthesis of 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one from 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Preparation Products And Raw materials

Raw materials

2-Pyridinecarboxamide, 3-[2-(5-chloro-2-iodophenyl)ethyl]-N-methyl-N-phenyl- 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile N-phenyl-3-[2-(3-chlorophenyl)ethyl]-2-pyridine carboxamide Carbon Hydrochloric acid

Preparation Products

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Suppliers

Global( 280)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10239	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-22	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 31251-41-9	US $0.00-0.00 / Kg/Drum	1KG	99%	100KGS	WUHAN FORTUNA CHEMICAL CO., LTD
	2019-12-26	8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 31251-41-9	US $1.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9
US $0.00-0.00 / Kg/Drum
99%
WUHAN FORTUNA CHEMICAL CO., LTD

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9
US $1.00 / KG
99%
Career Henan Chemical Co

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Spectrum

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(31251-41-9)¹HNMR 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(31251-41-9)¹³CNMR

31251-41-9(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one)Related Search:

Pyridine hydrobromide Copper Pyrithione 2-Chloro-3-cyanopyridine Zinc pyrithione Benzo[b]thien-2-ylboronic acid

Clopidol Pentachloropyridine Pyridine hydrofluoride 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity) Loratadine Impurity 17 3-Hydroxy loratadine Loratadine Impurity 13 Loratadine Impurity 13

8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol Loratadine Impurity 15 Loratadine EP IMpurity F

1of4

8-CHLORO-5,6-DIHYDRO-11H-BENZO-(5,6)-CYCLOHEPTA-(1,2-B)-PYRIMIDINE-11-ON 8-Chloro-10,11-dihydro-4-aza-5 8-chloro-10,11-dihydro-4-AZA-5H-benzo〔A,D〕cyclohepta-5-one 8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIMIDINE-11-ONE 4-Aza-8-chloro-10,11-dihydro-5H-benzo[a,d]cyclo-5-heptanone 8-CHLORO-10,11-DIHYDRO-4 AZA-5H-BENZO[A,D] CYCLOHEPTAN-5-ONE =98% 8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-ONE 8-CHLORO-10,11-DIHYDRO-4-AZA-5H-DIBENZO-(A,D)CYCLOHEPTAN-5-ONE 8-CHLORO-10,11-DIHYDRO-4-AZA-5H-BENZO[A,D] CYCLOHEPTAN-5-ONE 8-CHLORO-6,11-DIHYDRO-11-(1-METHYL-4-PIPERIDYLEDENE)-5H-BENZO(5,6)-CYCLOHEPTA(1,2,B)PYRIDINE 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one 11-dihydro-4-aza-5H-benzo[A 8-Chloro-10 D] cycloheptan-5-one 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclo hepta[1,2-b]pyridin-11- Loratadine Related Compound C (15 mg) (8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one) Loratadine EP IMpurity B Loratadine Related CoMpound C 11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one,8-chloro-5,6-dihydro- Loratadine impurity B 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Keto loratadine Loratadine Impurity 2(Loratadine EP Impurity B) Loratad Impurity B 8-Chloro-5,6-dihydro-11H-benzo[5.6] 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclo- 2-b]pyridin-11-one 6-dihydro-11H-benzo[5 8-Chloro-10,11-dihydro-4-AZA-5H-dibenzo(a,d)- Cyclohepten-5-One(or)(Loraketone) 13-chloro-4-azatricyclo[9.4.0.0,3,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-one 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Desloratadine Impurity) Loratidine EP Impurity B/ Loratidine Related Compound C 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptan-5-on... Loratadine Related Compound C (8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one) (1370269) Loratadine Impurity B（EP ） Loratadine USP Related Compound C 8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo (a,d)ycloheptan-5-one 2-chloromethyl-3-methy1-4-(2,2,2- triflu oroethoxy) pyridine hydrochloride Loratadine tricycline 8-chloro-5,6-dihydro-11H-benzo [5,6] cycloheptano [1,2-b] pyridin-11 one 8-chloro-10,Chemicalbook11-dihydro-4-AZA-5H-benzo〔A,D〕cyclohepta-5-one 13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-one Loratadine EP Impurity B (Loratadine USP Related Compound C) 31251-41-9 31521-41-9 C14H10ClNO Aromatics Heterocycles Intermediates Aromatics Compounds