3-Chloro-5-(trifluoromethyl)pyridine
- CAS No.
- 85148-26-1
- Chemical Name:
- 3-Chloro-5-(trifluoromethyl)pyridine
- Synonyms
- 3-TRIFLUOROMETHYL-5-CHLOROPYRIDINE;3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-5-(trifluoroMethyl)-;3-Chloro-5-(trifluoromethyl)pyridine97%;3-Chloro-5-(trifluoromethyl)pyridine 97%;3-Chloro-5-(trifluoromethyl)pyridine >3-Chloro-5-(trifluoromethyl)pyridine ISO 9001：2015 REACH
- CBNumber:
- CB4468417
- Molecular Formula:
- C6H3ClF3N
- Molecular Weight:
- 181.54
- MDL Number:
- MFCD00042227
- MOL File:
- 85148-26-1.mol
- MSDS File:
- SDS
| Melting point | 131.5 °C |
|---|---|
| Boiling point | 144°C |
| Density | 1.416±0.06 g/cm3(Predicted) |
| refractive index | 1.4460 to 1.4500 |
| Flash point | 54℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | 0.52±0.20(Predicted) |
| Appearance | Colorless to off-white <23°C Solid,>27°C Liquid |
| InChI | InChI=1S/C6H3ClF3N/c7-5-1-4(2-11-3-5)6(8,9)10/h1-3H |
| InChIKey | OMRCXTBFBBWTDL-UHFFFAOYSA-N |
| SMILES | C1=NC=C(C(F)(F)F)C=C1Cl |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn,T | |||||||||
| Risk Statements | 20/21/22-36/37/38-25 | |||||||||
| Safety Statements | 26-36/37/39-36-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, IRRITANT-HARMFUL | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
3-Chloro-5-(trifluoromethyl)pyridine price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 714488 | 3-Chloro-5-(trifluoromethyl)pyridine 97% | 85148-26-1 | 1g | $91.2 | 2023-06-20 | Buy |
| TCI Chemical | C2951 | 3-Chloro-5-(trifluoromethyl)pyridine >97.0%(GC) | 85148-26-1 | 1g | $37 | 2025-07-31 | Buy |
| TCI Chemical | C2951 | 3-Chloro-5-(trifluoromethyl)pyridine >97.0%(GC) | 85148-26-1 | 5g | $119 | 2025-07-31 | Buy |
| TRC | B427928 | 3-chloro-5-(trifluoromethyl)pyridine | 85148-26-1 | 1g | $45 | 2021-12-16 | Buy |
| AK Scientific | W8792 | 3-Chloro-5-(trifluoromethyl)pyridine | 85148-26-1 | 1g | $72 | 2021-12-16 | Buy |
3-Chloro-5-(trifluoromethyl)pyridine Chemical Properties,Uses,Production
Chemical Properties
light yellow crystalline
Uses
3-Chloro-5-(trifluoromethyl)pyridine (3CTFP) is a pyridinium salt that is a byproduct of the production of chlorofluorocarbons. It is used to reduce the level of chlorine in water, and it can be used as a pesticide. 3CTFP is also an anion that can be reduced to form the chloride ion. 3CTFP reacts with nucleophiles such as ammonia or amines, which leads to nucleophilic substitution reactions. This reaction can be reversed by adding acid. The product from this reaction is ammonia gas.
Synthesis
69045-84-7
85148-26-1
The general procedure for the synthesis of 3-chloro-5-trifluoromethylpyridine using 2,3-dichloro-5-trifluoromethylpyridine as starting material was as follows: zinc powder (1.18 g, 18.0 mmol) was added to a suspension of 2,3-dichloro-5-trifluoromethylpyridine (2.0 g, 9.30 mmol) in a solvent mixture of 80:20 (v/v) water and acetic acid (5 mL) at 90° C with stirring for 1 hour. Subsequently, zinc powder (1 g, 15.3 mmol) was made up and stirring was continued at 90°C for 15 minutes. After completion of the reaction, the mixture was cooled to room temperature, filtered and the filtrate was washed with dichloromethane. The filtrate was carefully concentrated and the residue was purified by silica gel column chromatography with an elution gradient of 100:0 to 0:100 (v/v) hexane:dichloromethane, resulting in 3-chloro-5-trifluoromethylpyridine as a colorless oil (0.120 g, 7% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.93 (s, 1H), 8.78 (s, 2H); GC-MS (EI) analysis showed m/z = 181.0, 183.0 [M].
References
[1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 28
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 20, p. 7150 - 7163
3-Chloro-5-(trifluoromethyl)pyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20188 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2161 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 3-Chloro-5-(trifluoromethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-07-25 | 3-Chloro-5-(trifluoromethyl)pyridine
85148-26-1
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-04-04 | 3-Chloro-5-(trifluoromethyl)pyridine
85148-26-1
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2024-04-08 | 3-Chloro-5-(trifluoromethyl)pyridine
85148-26-1
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 3-Chloro-5-(trifluoromethyl)pyridine
85148-26-1
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Chloro-5-(trifluoromethyl)pyridine
85148-26-1
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-Chloro-5-(trifluoromethyl)pyridine
85148-26-1
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
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