4-Benzyloxybenzeneboronic acid
- CAS No.
- 146631-00-7
- Chemical Name:
- 4-Benzyloxybenzeneboronic acid
- Synonyms
- 4-BENZYLOXYINDOLE;AKOS BRN-0054;RARECHEM AH PB 0041;4-Benzyloxyphenylboronic;4-BEZYLOXYPHENYLBORONICACID;4-BENZYLOXYPHENYBORONIC ACID;4-Benzyloxybenzeneboronicaci;4-(Benzyloxy)-phenylboronsure;4-BENZYLOXYPHENYLBORONIC ACID;P-BENZYLOXYPHENYLBORONIC ACID
- CBNumber:
- CB4470742
- Molecular Formula:
- C13H13BO3
- Molecular Weight:
- 228.05
- MDL Number:
- MFCD01075705
- MOL File:
- 146631-00-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(Benzyloxy)phenylboronic acid ≥95.0% | 666920 | 2g | $81.5 |
| 4-(Benzyloxy)phenylboronic acid ≥95.0% | 666920 | 10g | $282 |
| 4-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride) | B2145 | 1g | $31 |
| 4-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride) | B2145 | 5g | $93 |
| 4-BenzyloxybenzeneboronicAcid | B287060 | 10g | $95 |
| More product size | |||
| Melting point | 193-199 °C |
|---|---|
| Boiling point | 418.9±47.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, DMSO, Methanol |
| pka | 8.70±0.16(Predicted) |
| form | solid |
| color | White to Off-White |
| CAS DataBase Reference | 146631-00-7(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29310095 | |||||||||
| NFPA 704 |
|
4-Benzyloxybenzeneboronic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 666920 | 4-(Benzyloxy)phenylboronic acid ≥95.0% | 146631-00-7 | 2g | $81.5 | 2023-06-20 | Buy |
| Sigma-Aldrich | 666920 | 4-(Benzyloxy)phenylboronic acid ≥95.0% | 146631-00-7 | 10g | $282 | 2023-06-20 | Buy |
| TCI Chemical | B2145 | 4-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride) | 146631-00-7 | 1g | $31 | 2025-07-31 | Buy |
| TCI Chemical | B2145 | 4-Benzyloxyphenylboronic Acid (contains varying amounts of Anhydride) | 146631-00-7 | 5g | $93 | 2025-07-31 | Buy |
| TRC | B287060 | 4-BenzyloxybenzeneboronicAcid | 146631-00-7 | 10g | $95 | 2021-12-16 | Buy |
4-Benzyloxybenzeneboronic acid Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
suzuki reaction
Uses
It is used as electronic intermediate. It is also utilized in HPLC and NMR spectroscopy.
Uses
4-Benzyloxybenzeneboronic Acid is a reagent in the synthesis of arylalkenylpropargylamines as neuroprotective and potent selective monoamine oxidase B inhibitors. Also used to prepare pyridone alkaloids used as antiproliferative agents.
General Description
May contain varying amounts of anhydride
Synthesis
6793-92-6
146631-00-7
First, 5.07 g of magnesium shavings and 80 mL of anhydrous tetrahydrofuran were added to a 500 mL three-necked flask that had been displaced by argon. A small amount of iodine crystals was added to activate the magnesium. Subsequently, 100 mL of anhydrous tetrahydrofuran solution containing 45.7 g of 4-bromo-1-benzyloxybenzene (obtained from synthesis step 10-a) was slowly added dropwise to the above mixture under stirring conditions. After the dropwise addition was completed, the reaction mixture was heated and refluxed and stirred for 30 minutes and subsequently cooled to -40°C. At this temperature, 60 mL of anhydrous tetrahydrofuran solution containing 21.66 g of trimethylborate was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was allowed to gradually warm up to room temperature and reflux stirring was continued for 30 minutes. After that, the reaction mixture was cooled to 0 °C again, 200 mL of 10% aqueous sulfuric acid solution was added and stirred for 1 hour. Upon completion of the reaction, toluene was added to the mixture to extract the organic layer. The organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the crude product obtained was recrystallized from toluene to give 36.5 g (yield: 92.1%) of the title compound 4-benzyloxyphenylboronic acid.
References
[1] Patent: US6388146, 2002, B1. Location in patent: Page column 35
[2] Angewandte Chemie - International Edition, 2004, vol. 43, # 39, p. 5235 - 5238
[3] Organic and Biomolecular Chemistry, 2010, vol. 8, # 21, p. 4831 - 4833
[4] European Journal of Organic Chemistry, 2012, # 7, p. 1448 - 1454
[5] Journal of the American Chemical Society, 2011, vol. 133, # 39, p. 15674 - 15685
4-Benzyloxybenzeneboronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8826 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 4-Benzyloxybenzeneboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 4-Benzyloxybenzeneboronic acid
146631-00-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | 4-Benzyloxybenzeneboronic acid
146631-00-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | 4-Benzyloxybenzeneboronic acid
146631-00-7
|
US $8.00 / kg | 1kg | 99% | 10MT | Career Henan Chemical Co |
-
- 4-Benzyloxybenzeneboronic acid
146631-00-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Benzyloxybenzeneboronic acid
146631-00-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Benzyloxybenzeneboronic acid
146631-00-7
- US $8.00 / kg
- 99%
- Career Henan Chemical Co
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