KLF4 ANTIBODY

Source

Rabbit

Applications

KLF4 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.

Reactivity

Human;Mouse;Monkey

Immunogen

Anti-human KLF4 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KLF4 amino acids 1-170 purified from E. coli.

Background

KLF4 (aka the gut-enriched Kruppel-like factor-GKLF), is a zinc finger-containing transcription factor which is a member of the Kruppel-like family of transcription factors. KLF4 plays key roles during the proliferation and differentiation of epithelial cells. Particularly, it is found mainly in the gut and has been shown to be expressed during growth arrest. KLF4 is also involved in cell cycle control since expression of KLF4 inhibits DNA synthesis by blocking the G1/S phase of the cell cycle.

References

[1] Yet,S.F. et al. (1998) J Biol Chem 273, 1026-31.
[2] Segre, J.A. et al. (1999) Nat Genet 22, 356-60.
[3] Katz, J.P. et al. (2005) Gastroenterology 128, 935-45.
[4] Evans, P.M. and Liu, C. (2008) Acta Biochim Biophys Sin (Shanghai) 40, 554-64.
[5] Foster, K.W. et al. (2005) Oncogene 24, 1491-500.
[6] Rowland, B.D. and Peeper, D.S. (2006) Nat Rev Cancer 6, 11-23.
[7] Takahashi, K. and Yamanaka, S. (2006) Cell 126, 663-76.
[8] Meissner, A. et al. (2007) Nat Biotechnol 25, 1177-81.
[9] Park, I.H. et al. (2008) Nature 451, 141-6.

Raw materials

Preparation Products