COPS6 ANTIBODY
- CAS No.
- Chemical Name:
- COPS6 ANTIBODY
- Synonyms
- COPS6 ANTIBODY
- CBNumber:
- CB44733728
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
COPS6 ANTIBODY price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb419639 | COPS6 Antibody | 100μl | $360 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb1641 | COPS6 antibody Affinity purified by Protein A | 100μg | $421.6 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb1641 | COPS6 antibody Affinity purified by Protein A | 200μg | $673.2 | 2021-12-16 | Buy |
COPS6 ANTIBODY Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
COP9 signalosome complex subunit 6 belongs to the multisubunit COP9 signalsome which modulates protein ubiquitination to affect cellular processes such as cell-cycle progression and DNA damage repair. COPS6 is a putative oncogene that has been shown to be overexpressed in a significant percentage of colorectal cancers with poor prognosis. Mechanistically, research studies have shown that a signaling axis involving EGFR and ERK promotes tumor growth through the phosphorylation of COPS6, which indirectly facilitates downstream stabilization of β-catenin and enhancement of its transcriptional acitivity. Reasearch studies have also demonstrated that COPS6 contributes to tumorigenesis through the stabilization of other oncoproteins like c-Myc, MDM2 and E6AP.
References
[1] Wei, N. and Deng, X.W. (2003) Annu Rev Cell Dev Biol 19, 261-86.
[2] Verwoerd, C.D. et al. (1989) Rhinol Suppl 9, 87-96.
[3] Zhao, R. et al. (2011) J Clin Invest 121, 851-65.
[4] Gao, S. et al. (2015) Oncotarget 6, 28026-41.
[5] Chen, J. et al. (2014) Nat Commun 5, 5384.
COPS6 ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
COPS6 ANTIBODY Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
