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2-Fluoro-4-(trifluoromethyl)aniline

2-Fluoro-4-(trifluoromethyl)aniline structure

CAS No.: 69409-98-9

Chemical Name:: 2-Fluoro-4-(trifluoromethyl)aniline

Synonyms: 2-Fluoro-4-(trifluor;4-aMino-3-flurorbenzotrifluoride;4-AMINO-3-FLUOROBENZOTRIFLUORIDE;Aminofluorobenzotrifluoride 43---;2-fluoro-4-（trifluoromethyl）anline;2-FLUORO-4-(TRIFLUOROMETHYL)ANILINE;2-Fluoro-4-trifluoromethyl-phenylamine;BenzenaMine, 2-fluoro-4-(trifluoroMethyl)-;2-Fluoro-4-(trifluoromethyl)aniline, alpha,alpha,alpha,2-Tetrafluoro-p-toluidine

CBNumber:: CB4475196

Molecular Formula:: C7H5F4N

Molecular Weight:: 179.11

MDL Number:: MFCD01631629

MOL File:: 69409-98-9.mol

MSDS File:: SDS

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
2-Fluoro-4-(trifluoromethyl)aniline Aldrich^CPR	CDS003152	1 g	$73.1
2-Fluoro-4-(trifluoromethyl)aniline	B435265	50mg	$45
2-Fluoro-4-(trifluoromethyl)aniline	B435265	100mg	$60
4-AMINO-3-FLUOROBENZOTRIFLUORIDE 95.00%	HCH0019764	25G	$1233.54
4-Amino-3-fluorobenzotrifluoride 98%	001722	5g	$49
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2-Fluoro-4-(trifluoromethyl)aniline Properties

Boiling point	55 °C(Press: 0.3 Torr)
Density	1.383±0.06 g/cm3(Predicted)
refractive index	1.4650
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	liquid
pka	1.37±0.10(Predicted)
color	Clear, faint yellow
CAS DataBase Reference	69409-98-9(CAS DataBase Reference)
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Warning

Hazard statements

H227-H302-H311-H315-H319-H332

Precautionary statements

P280h-P305+P351+P338-P309-P310

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36/37/39

RIDADR

2810

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

2921420090

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
3		0

2-Fluoro-4-(trifluoromethyl)aniline price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS003152	2-Fluoro-4-(trifluoromethyl)aniline Aldrich^CPR	69409-98-9	1 g	$73.1	2025-07-31	Buy
TRC	B435265	2-Fluoro-4-(trifluoromethyl)aniline	69409-98-9	50mg	$45	2021-12-16	Buy
TRC	B435265	2-Fluoro-4-(trifluoromethyl)aniline	69409-98-9	100mg	$60	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0019764	4-AMINO-3-FLUOROBENZOTRIFLUORIDE 95.00%	69409-98-9	25G	$1233.54	2021-12-16	Buy
Matrix Scientific	001722	4-Amino-3-fluorobenzotrifluoride 98%	69409-98-9	5g	$49	2021-12-16	Buy

Product number	Packaging	Price	Buy
CDS003152	1 g	$73.1	Buy
B435265	50mg	$45	Buy
B435265	100mg	$60	Buy
HCH0019764	25G	$1233.54	Buy
001722	5g	$49	Buy

2-Fluoro-4-(trifluoromethyl)aniline Chemical Properties,Uses,Production

Synthesis

2-FLUORO-4-(TRIFLUOROMETHYL)BENZOIC ACID

115029-24-8

69409-98-9

General procedure for the synthesis of 4-amino-3-fluorobenzotrifluoride from 2-fluoro-4-(trifluoromethyl)benzoic acid: 2-fluoro-4-(trifluoromethyl)benzoic acid (1 kg, 4.805 mol, 1.00 eq.) and CuCl (14.26 g, 0.144 mol, 0.03 eq.) were dissolved in 0-BuOH (11.7 L). Triethylamine (TEA, 533.8 g, 5.286 mol, 1.10 eq.) was added slowly and dropwise at room temperature. The reaction mixture was then heated to 50 °C and diphenylphosphoryl azide (DPPA, 1393 g, 5.045 mol, 1.05 eq.) was added slowly dropwise at 50-60 °C. The reaction mixture was heated at 80-85 °C overnight. After completion of the reaction, the solution was concentrated under reduced pressure. The residue was dissolved in water and filtered. The filtrate was extracted with ethyl acetate and the organic layer was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was dissolved in tert-butyl methyl ether (TBME) and HCl gas was passed into it for 2 hours. The filtrate was collected, dissolved in water and alkalized with 2M NaOH solution. The alkalized solution was extracted with TBME and the organic layer was dried and concentrated under reduced pressure to give 2-fluoro-4-(trifluoromethyl)aniline (498 g, 58% yield) as a red oil. The product was confirmed by 1H-NMR (300 MHz, CDCl3): δ 7.27 (m, 2H), 6.82 (m, 1H), 4.05 (bs, 2H); mass spectrum (MS): m/z = 180 [M + H]+.

References

[1] Patent: US2013/281710, 2013, A1. Location in patent: Paragraph 0268; 269; 270

2-Fluoro-4-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

2-FLUORO-4-(TRIFLUOROMETHYL)BENZOIC ACID tert-Butanol Triethylamine Diphenylphosphoryl azide Copper(I) chloride

Preparation Products

2-Fluoro-4-(trifluoromethyl)aniline Suppliers

Global( 162)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8826	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Nanjing Dolon Biotechnology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Richest Group Ltd	58
Fuxin Pharmaceutical	58
Antai Fine Chemical Technology Co.,Limited	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from 2-Fluoro-4-(trifluoromethyl)aniline manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-20	2-Fluoro-4-(trifluoromethyl)aniline 69409-98-9	US $1.00 / KG	100g	98%	200KG	Career Henan Chemical Co

2-Fluoro-4-(trifluoromethyl)aniline
69409-98-9
US $1.00 / KG
98%
Career Henan Chemical Co

2-Fluoro-4-(trifluoromethyl)aniline Spectrum

2-Fluoro-4-(trifluoromethyl)aniline(69409-98-9)¹HNMR

69409-98-9(2-Fluoro-4-(trifluoromethyl)aniline)Related Search:

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2-FLUORO-4-(TRIFLUOROMETHYL)ANILINE 4-AMINO-3-FLUOROBENZOTRIFLUORIDE 2-fluoro-4-（trifluoromethyl）anline Aminofluorobenzotrifluoride 43--- 2-Fluoro-4-(trifluor BenzenaMine, 2-fluoro-4-(trifluoroMethyl)- 4-aMino-3-flurorbenzotrifluoride 2-Fluoro-4-(trifluoromethyl)aniline, alpha,alpha,alpha,2-Tetrafluoro-p-toluidine 2-Fluoro-4-trifluoromethyl-phenylamine 69409-98-9 69409-98-8 Benzenes Aromatic Halides (substituted)