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PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE

CAS No.
877997-98-3
Chemical Name:
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE
Synonyms
Acotiamide Impurity 35;Alcotimide intermediate 2;PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE;Phenyl 2-hydroxy-4,5-dimethyoxybenzoate;Phenyl -2-hydroxy -4,5-dimethyl benzoate;2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester;Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester;Ethyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate;Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide);4, 5-dimethoxybenzoic acid, phenyl ester, 2-hydroxy-4, 5-dimethoxybenzoic acid
CBNumber:
CB4478258
Molecular Formula:
C15H14O5
Molecular Weight:
274.27
MDL Number:
MFCD08063359
MOL File:
Mol file
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
Phenyl2-Hydroxy-4,5-dimethoxybenzoate P321060 50mg $45
Phenyl2-hydroxy-4,5-dimethoxybenzoate X5044 250mg $73
PHENYL-2-HYDROXY-4,5-DIMETHOXYBENZOATE 98.00% CHM0294571 25G $1761.38
Phenyl2-hydroxy-4,5-dimethoxybenzoate 98+% A1476019 100g $107
Phenyl2-hydroxy-4,5-dimethoxybenzoate 877997983 10g $161.6
More product size

PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Properties

Boiling point 431.2±45.0 °C(Predicted)
Density 1.250±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 8.83±0.23(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P321060 Phenyl2-Hydroxy-4,5-dimethoxybenzoate 877997-98-3 50mg $45 2021-12-16 Buy
AK Scientific X5044 Phenyl2-hydroxy-4,5-dimethoxybenzoate 877997-98-3 250mg $73 2021-12-16 Buy
American Custom Chemicals Corporation CHM0294571 PHENYL-2-HYDROXY-4,5-DIMETHOXYBENZOATE 98.00% 877997-98-3 25G $1761.38 2021-12-16 Buy
Ambeed A1476019 Phenyl2-hydroxy-4,5-dimethoxybenzoate 98+% 877997-98-3 100g $107 2021-12-16 Buy
Alichem 877997983 Phenyl2-hydroxy-4,5-dimethoxybenzoate 877997-98-3 10g $161.6 2021-12-16 Buy
Product number Packaging Price Buy
P321060 50mg $45 Buy
X5044 250mg $73 Buy
CHM0294571 25G $1761.38 Buy
A1476019 100g $107 Buy
877997983 10g $161.6 Buy

PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Chemical Properties,Uses,Production

Application

2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester is an important intermediate in the synthesis of 2-aminothiazole compounds. 2-Aminothiazole compounds are an important class of heterocyclic compounds in organic medicinal chemistry, possessing a wide range of biological activities. They can be used as local anesthetics and have anticonvulsant, antiviral, antibacterial, and insecticidal effects.

Synthesis

Triphenyl phosphite

101-02-0

2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID

5722-93-0

PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE

877997-98-3

(1) Toluene (1.5 g), triphenyl phosphite (2.35 g), 2-hydroxy-4,5-dimethoxybenzoic acid (1.5 g) and concentrated sulfuric acid (40.3 μL) were mixed in a reaction flask under argon protection. The reaction mixture was refluxed under stirring conditions for 2.5 hours. After completion of the reaction, it was cooled to room temperature, methanol (5 g) was added and stirring was continued for 30 min. Subsequently, water (2.5 g) was added to the mixture and stirred for another 30 minutes. The precipitated crystals were filtered and dried under reduced pressure to afford phenyl 2-hydroxy-4,5-dimethoxybenzoate (2.0 g) in 96% yield.

References

[1] Patent: WO2006/22252, 2006, A1. Location in patent: Page/Page column 11
[2] Patent: US2013/253222, 2013, A1. Location in patent: Paragraph 0039
[3] Patent: CN105439977, 2016, A. Location in patent: Paragraph 0016

PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Preparation Products And Raw materials

Global( 132)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Anhui Dexinjia Biopharm Co., Ltd
+86-531-82375818 +86-15064153060 sales01@jndxj.com China 317 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 52513593@qq.com CHINA 2972 58
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
Shanghai Yingrui Biopharma Co.,Ltd
21-33585366 export01@shyrchem.com CHINA 1319 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58

View Lastest Price from PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
phenyl 2-hydroxy-4,5-dimethoxybenzoate pictures 2025-06-20 phenyl 2-hydroxy-4,5-dimethoxybenzoate
877997-98-3
US $150.00 / Kg/Bag 1Kg/Bag ≥98% 5000kg/month Hebei Yanxi Chemical Co., Ltd.
Phenyl 2-hydroxy-4,5-dimethoxybenzoate pictures 2023-06-26 Phenyl 2-hydroxy-4,5-dimethoxybenzoate
877997-98-3
US $100.00 / KG 10g 99% 500kg/month Hebei Mingeng Biotechnology Co., Ltd
Phenyl2-hydroxy-4,5-dimethoxybenzoate pictures 2023-05-27 Phenyl2-hydroxy-4,5-dimethoxybenzoate
877997-98-3
US $100.00 / kg 25kg 99% 500t/month Henan Bao Enluo International TradeCo.,LTD

PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Spectrum

Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide) Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester Acotiamide Impurity 35 Phenyl 2-hydroxy-4,5-dimethyoxybenzoate Ethyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE Phenyl 2-hydroxy-4,5-dimethoxybenzoate Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide) 2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester 4, 5-dimethoxybenzoic acid, phenyl ester, 2-hydroxy-4, 5-dimethoxybenzoic acid Alcotimide intermediate 2 Phenyl -2-hydroxy -4,5-dimethyl benzoate 877997-98-3