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1-Methylpiperazine

1-Methylpiperazine structure

CAS No.: 109-01-3

Chemical Name:: 1-Methylpiperazine

Synonyms: N-METHYLPIPERAZINE;methylpiperazine;NMPRZ;4-Methylpiperazine;N-Methylpiperazin;Piperazine,1-methyl-;CL046;AKOS BBS-00003665;1-methyl-piperazin;METHYLPIPERAZINE-N

CBNumber:: CB4478526

Molecular Formula:: C5H12N2

Molecular Weight:: 100.16

MDL Number:: MFCD00005966

MOL File:: 109-01-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-10 10:27:16

Product description	Number	Pack Size	Price
Cyclizine impurity A European Pharmacopoeia (EP) Reference Standard	Y0000886	15 mg	$167
1-Methylpiperazine British Pharmacopoeia (BP) Reference Standard	BP1118	15MG	$251
1-Methylpiperazine for synthesis	8.05859	5ml	$38.2
1-Methylpiperazine for synthesis	8.05859	250ML	$131
1-Methylpiperazine 99%	130001	5g	$40.1
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1-Methylpiperazine Properties

Melting point	-6 °C
Boiling point	138 °C(lit.)
Density	0.903 g/mL at 25 °C(lit.)
vapor density	3.5 (vs air)
vapor pressure	12 hPa (20 °C)
refractive index	n20/D 1.466(lit.)
Flash point	108 °F
storage temp.	2-8°C
solubility	Chloroform (Soluble), Methanol (Soluble)
pka	pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1)
form	Liquid
color	Clear
Specific Gravity	0.903
PH	11-12 (50g/l, H2O, 20℃)
explosive limit	1.2-9.9%(V)
Viscosity	2.27mm2/s
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	102724
Henry's Law Constant	1.8×10³ mol/(m³Pa) at 25℃, Nguyen (2013)
InChI	1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3
InChIKey	PVOAHINGSUIXLS-UHFFFAOYSA-N
SMILES	CN1CCNCC1
LogP	-0.57 at 25℃
Surface tension	30.65mN/m at 298.15K
CAS DataBase Reference	109-01-3(CAS DataBase Reference)
FDA UNII	B92I95EL9Q
NIST Chemistry Reference	Piperazine, 1-methyl-(109-01-3)
EPA Substance Registry System	Piperazine, 1-methyl- (109-01-3)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS06

Signal word

Danger

Hazard statements

H226-H312-H314-H331

Precautionary statements

P210-P260-P280-P304+P340+P310-P305+P351+P338-P370+P378

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

T,F,C,Xi

Risk Statements

10-21-23-34-36/37/38-20/21

Safety Statements

16-26-36/37/39-45-36

RIDADR

UN 2734 8/PG 2

WGK Germany

RTECS

TM1225000

Autoignition Temperature

320 °C

Hazard Note

Flammable/Toxic/Corrosive/Store under nitrogen

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29335995

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B
Skin Sens. 1B

Toxicity

LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
2		0

1-Methylpiperazine price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000886	Cyclizine impurity A European Pharmacopoeia (EP) Reference Standard	109-01-3	15 mg	$167	2026-04-30	Buy
Sigma-Aldrich	BP1118	1-Methylpiperazine British Pharmacopoeia (BP) Reference Standard	109-01-3	15MG	$251	2026-04-30	Buy
Sigma-Aldrich	8.05859	1-Methylpiperazine for synthesis	109-01-3	5ml	$38.2	2026-04-30	Buy
Sigma-Aldrich	8.05859	1-Methylpiperazine for synthesis	109-01-3	250ML	$131	2026-04-30	Buy
Sigma-Aldrich	130001	1-Methylpiperazine 99%	109-01-3	5g	$40.1	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0000886	15 mg	$167	Buy
BP1118	15MG	$251	Buy
8.05859	5ml	$38.2	Buy
8.05859	250ML	$131	Buy
130001	5g	$40.1	Buy

1-Methylpiperazine Chemical Properties,Uses,Production

Chemical Properties

clear liquid

Uses

1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)

Uses

1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

Definition

ChEBI: 1-Methylpiperazine is a N-methylpiperazine.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

1-Methylpiperazine synthesis

Synthesis of 1-Methylpiperazine from 1-methyl-4-nitrosopiperazine

1-Methylpiperazine Preparation Products And Raw materials

Raw materials

PIPERAZINE DIHYDROCHLORIDE PIPERAZINE HEXAHYDRATE Carbon dioxide Piperazine Methanol

Preparation Products

AZIMILIDE 3-(4-Methylpiperazin-1-yl)aniline 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile 1-Amino-4-methylpiperazine

Zopiclone 1-METHYLPIPERAZINE DIHYDROCHLORIDE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine

3-(4-Methylpiperazin-1-ylmethyl)benzoic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile Chlorcyclizine hydrochloride Levofloxacin

(3,4-DIAMINO-PHENYL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol Ethyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate 3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one CHLORCYCLIZINE 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine

1-AdaMantanethylaMine 1-FORMYL-4-METHYLPIPERAZINE 4-(4-METHYLPIPERAZINOMETHYL)BENZOIC ACID (2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde

Clozapine 1-METHYL-4-(3-NITROPHENYL)PIPERAZINE 4-[(4-Methylpiperazin-1-yl)methyl]aniline 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine

4-(4-Methylpiperazino)aniline 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone 1-METHYL-4-(4-NITROBENZYL)PIPERAZINE 1-methyl-4-nitrosopiperazine

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1-Methylpiperazine Suppliers

Global( 795)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Believe Chemical PTE.LTD	+86-18553607090 +8618553607090	1093908296@qq.com	China	1663	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+86-519-85525359 +86-15995072465	sales@xuanmingchem.com	China	912	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+15184799099	lbaochemicals@gmail.com	China	671	58
Sinoway Industrial co., ltd.	+86-0592-5800732 +86-13806035118	xie@china-sinoway.com	China	1369	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55

Supplier	Advantage
Shandong Believe Chemical PTE.LTD	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Sinoway Industrial co., ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55

Uses and Hazards of 1-Methylpiperazine
1-Methylpiperazine is a colorless to almost clear liquid, it is a common building block used in organic synthesis.
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1-Methylpiperazine: synthesis, applications and safety
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1-Methylpiperazine: exploring the properties and applications of a versatile organic compound
1-Methylpiperazine is a chemical compound with interesting properties and diverse applications.
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View Lastest Price from 1-Methylpiperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-01	1-Methylpiperazine 109-01-3			0.99		RongNa Biotechnology Co.,Ltd
2026-05-01	1-Methylpiperazine 109-01-3	US $0.00 / kg	1kg	98%	Customise	Hefei Lbao Physical & Chemical Science Co.,Ltd
2026-04-30	1-Methylpiperazine 109-01-3	US $5.00 / kg	1kg	≥98%	500mt/year	Jinan Finer Chemical Co., Ltd

1-Methylpiperazine
109-01-3
0.99
RongNa Biotechnology Co.,Ltd

1-Methylpiperazine
109-01-3
US $0.00 / kg
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

1-Methylpiperazine
109-01-3
US $5.00 / kg
≥98%
Jinan Finer Chemical Co., Ltd

1-Methylpiperazine Spectrum

1-Methylpiperazine(109-01-3)MS 1-Methylpiperazine(109-01-3)¹HNMR 1-Methylpiperazine(109-01-3)¹³CNMR 1-Methylpiperazine(109-01-3)IR1 1-Methylpiperazine(109-01-3)IR2 1-Methylpiperazine(109-01-3)Raman

109-01-3(1-Methylpiperazine)Related Search:

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NMPRZ 1-methyl-piperazin 1-METHYLPIPERAZINE FOR SYNTHESIS Cyclizine Related CoMpound A N-Methyl piperazine 1-Methylpiperazine, 99+% 100GR 1-Methylpiperazine, 99+% 500GR 1-Methylpiperazine, 99+% 5GR Olanzapine Impurity 15 CL046 1-Methylpiperazine / N-Methylpiperazine Piperazine,1-methyl- LABOTEST-BB LTBB000517 METHYLPIPERAZINE-N 1-METHYLPIPERAZINE AKOS BBS-00003665 1-METHYLPIPERAZINE, STANDARD FOR GC N-MethylPiperazineForSynthesis N-EthylPiperazineForSynthesis N-Methylpiperazine, 98+% 1-Methylpiperazine, 99+% N-Methylpiperazin n-METHYL PIPERAZINE extrapure 1-Methylpiperazine, 98+% 1-Methylpiperazine> Cyclizine impurity A CRS Diethylcarbamazine EP Impurity A Imatinib EP Impurity G N-Methylpiperazini N-METHYL PIPERASINE 1-Methylpiperazine ISO 9001：2015 REACH Cyclizine impurity A (Y0000886) 1-Methylpiperazine extrapure, 99% Cyclizine Related Compound A (1-methylpiperazine) (1154015) Imatinib Mesilate Impurity G Cyclizine Hydrochloride Impurity A Cyclizine USP Related Compound A Imatinib Mesilate EP Impurity G Imatinib Impurity 54 4-((3-carboxy-2-hydroxynaphthalen-1-yl)methyl)-3-hydroxy-7-methyl-2-naphthoic acid N-Methyl Piperazine 99% For Synthesis N-Methyl Peprazine 1-Methyipiperazine Chlorcyclizine EP Impurity A N-Methylpiperazine,(S) Imatinib Mesylate Imp G (pharmeuropa): 1-Methylpiperazine N-Methylpiperazine (Imatinib Impurity) Chlorcyclizine EP Impurity A (Cyclizine EP Impurity A, Cyclizine USP Related Compound A) N-METHYLPIPERAZINE 4-Methylpiperazine methylpiperazine 109-01-3 1109-01-3 468-79-0 203-639-5 NC4H8NCH3 AMINE Building Blocks

1-Methylpiperazine

1-Methylpiperazine Properties

SAFETY

Risk and Safety Statements

1-Methylpiperazine price More Price(43)

1-Methylpiperazine Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Definition

Hazard

Flammability and Explosibility

Safety Profile

1-Methylpiperazine synthesis

1-Methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methylpiperazine Suppliers

Related articles

View Lastest Price from 1-Methylpiperazine manufacturers

1-Methylpiperazine Spectrum

109-01-3(1-Methylpiperazine)Related Search: