DMU2139
- CAS No.
- 1821143-80-9
- Chemical Name:
- DMU2139
- Synonyms
- CYP1B1 inhibitor;DMU2139(CYP1B1 inhibitor 6j);DMU2139;DMU-2139;DMU 2139;CYP1B1 INHIBITOR;1821143-80-9;(E)-1-(6-methoxynaphthalen-2-yl)-3-pyridin-3-ylprop-2-en-1-one;2-Propen-1-one, 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-, (2E)-
- CBNumber:
- CB44796646
- Molecular Formula:
- C19H15NO2
- Molecular Weight:
- 289.33
- MDL Number:
- MOL File:
- 1821143-80-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| DMU2139 >98% | orb746473 | 100mg | $760 |
| DMU2139 >98% | orb746473 | 250mg | $1200 |
| DMU2139 >98% | orb746473 | 1g | $2370 |
| DMU2139 >98.0% | CS-0021084 | 50mg | $750 |
| DMU2139 >98.0% | CS-0021084 | 100mg | $1200 |
| Boiling point | 488.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.199±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility |
DMSO:77.5(Max Conc. mg/mL);267.86(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);17.28(Max Conc. mM) |
| form | Solid |
| pka | 3.80±0.11(Predicted) |
| color | Light yellow to yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
DMU2139 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb746473 | DMU2139 >98% | 1821143-80-9 | 100mg | $760 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb746473 | DMU2139 >98% | 1821143-80-9 | 250mg | $1200 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb746473 | DMU2139 >98% | 1821143-80-9 | 1g | $2370 | 2026-05-06 | Buy |
| ChemScene | CS-0021084 | DMU2139 >98.0% | 1821143-80-9 | 50mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0021084 | DMU2139 >98.0% | 1821143-80-9 | 100mg | $1200 | 2021-12-16 | Buy |
DMU2139 Chemical Properties,Uses,Production
Uses
DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
Biological Activity
DMU2139 is a potent and specific cytochrome P4501B1 (CYP1B1) inhibitor with IC50 values of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
in vitro
DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC 50 is reversed back to 8.3 μM from 61 μM ( seen in CYP1B1-expressing cells without any inhibitor). The EC 50 value, in the presence of DMU2139, resembles the EC 50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein.
target
| CYP1B1 9 nM (IC 50 ) | CYP1A1 795 nM (IC 50 ) |
IC 50
CYP1B1: 9 nM (IC50); CYP1A1: 795 nM (IC50)
References
[1] Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174. DOI:10.1016/j.ejmech.2017.02.016
DMU2139 Preparation Products And Raw materials
Raw materials
Preparation Products
DMU2139 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7999 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2970 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9798 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1982 | 58 |
