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Methyl 4-(chloroformyl)butyrate

Methyl 4-(chloroformyl)butyrate Structure
Methyl 4-(chloroformyl)butyrate structure
CAS No.
1501-26-4
Chemical Name:
Methyl 4-(chloroformyl)butyrate
Synonyms
METHYL 5-CHLORO-5-OXOPENTANOATE;Methyl 5-chloro-5-;Methyl 4-(chloroform;METHYL GLUTARYL CHLORIDE;METHYL 5-CHLORO-5-OXOVALERATE;CARBOMETHOXYL BUTYRYL CHLORIDE;METHYL 4-(CHLOROFORMYL)BUTYRATE;METHYL 5-CHLORO-5-OXOVALERATE,98%;Methyl 4-(Chlorocarbonyl)butyrate;Methyl 4-(chlorocarbonyl)butanoate
CBNumber:
CB4480260
Molecular Formula:
C6H9ClO3
Molecular Weight:
164.59
MDL Number:
MFCD00000756
MOL File:
1501-26-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:26:45
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Methyl 4-(chloroformyl)butyrate Properties

Boiling point 110 °C/17 mmHg (lit.)
Density 1.191 g/mL at 25 °C (lit.)
refractive index n20/D 1.445(lit.)
Flash point 180 °F
storage temp. Inert atmosphere,2-8°C
solubility Chloroform, Hexane
form Oil
color Clear Colourless
Water Solubility reacts
Sensitive Moisture Sensitive
BRN 1762383
InChI 1S/C6H9ClO3/c1-10-6(9)4-2-3-5(7)8/h2-4H2,1H3
InChIKey JCAZSWWHFJVFPP-UHFFFAOYSA-N
SMILES COC(=O)CCCC(Cl)=O
CAS DataBase Reference 1501-26-4(CAS DataBase Reference)
FDA UNII U7H8283W54
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45-24/25
RIDADR  UN 3265 8/PG 2
WGK Germany  3
F  10-21
HazardClass  8
PackingGroup  II
HS Code  2918300090
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
2
3 0

Methyl 4-(chloroformyl)butyrate price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M35355 Glutaric acid monomethyl ester chloride 98% 1501-26-4 10g $90.75 2026-04-30 Buy
Sigma-Aldrich M35355 Glutaric acid monomethyl ester chloride 98% 1501-26-4 50g $430.5 2026-04-30 Buy
TRC TRC-M227420-5G Methyl 4-(Chloroformyl)butyrate 1501-26-4 5g $109 2026-06-03 Buy
TRC TRC-M227420-1G Methyl 4-(Chloroformyl)butyrate 1501-26-4 1g $72 2026-06-03 Buy
TRC TRC-M227420-10G Methyl 4-(Chloroformyl)butyrate 1501-26-4 10g $179 2026-06-03 Buy
Product number Packaging Price Buy
M35355 10g $90.75 Buy
M35355 50g $430.5 Buy
TRC-M227420-5G 5g $109 Buy
TRC-M227420-1G 1g $72 Buy
TRC-M227420-10G 10g $179 Buy

Methyl 4-(chloroformyl)butyrate Chemical Properties, Uses, Production

Chemical Properties

clear colourless to light yellow liquid

Uses

Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.

Synthesis

Methanol

67-56-1

Glutaric anhydride

108-55-4

Methyl 4-(chloroformyl)butyrate

1501-26-4

1. 100 g (0.878 mol) of glutaric anhydride was dissolved in 50 mL of anhydrous methanol and heated to reflux for 1 h. 2. Upon completion of the reaction, unreacted methanol was removed by distillation under reduced pressure. 3. The reaction mixture was cooled to room temperature, and 200 mL of acetochloride was slowly added. 4. The reaction mixture was heated for 6 h., wherein after 2 h of heating the remaining dichloro sulfoxide.5. Finally, the fractions were dried at 96 °C to 98 °C/10 mmHg to give 124.2 g of methyl 4-chlorocarbonylbutyrate as a light yellow liquid in 86.4% yield.

References

[1] Patent: CN103864658, 2016, B. Location in patent: Paragraph 0056; 0057
[2] Tetrahedron Letters, 1984, vol. 25, # 39, p. 4371 - 4374
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, # 6, p. 915 - 923

Methyl 4-(chloroformyl)butyrate Preparation Products And Raw materials

Raw materials

Methanol Glutaric anhydride Thionyl chloride N,N-Dimethylformamide

Preparation Products

Bendamustine hydrochloride Hexadecanedioic acid Hexanoic acid, 6-bromo-5-oxo-, methyl ester

Methyl 4-(chloroformyl)butyrate Suppliers

Global Suppliers ( 176)
Supplier Tel Email Country ProdList Advantage
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57
Supplier Advantage
Alfa Aesar 84
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Syntechem Co.,Ltd 57
Tianjin heowns Biochemical Technology Co., Ltd. 57

View Latest Price from Methyl 4-(chloroformyl)butyrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 4-(chloroformyl)butyrate pictures 2025-04-04 Methyl 4-(chloroformyl)butyrate
1501-26-4
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Methyl 4-(chloroformyl)butyrate pictures 2021-07-13 Methyl 4-(chloroformyl)butyrate
1501-26-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Methyl 4-(chloroformyl)butyrate pictures 2021-07-10 Methyl 4-(chloroformyl)butyrate
1501-26-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

Methyl 4-(chloroformyl)butyrate Spectrum

Methyl 4-(chloroformyl)butyrate(1501-26-4)1HNMRMethyl 4-(chloroformyl)butyrate(1501-26-4)IRMethyl 4-(chloroformyl)butyrate(1501-26-4)RamanMethyl 4-(chloroformyl)butyrate(1501-26-4)FT-IR

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1of4

Methyl 4-(chlorocarbonyl)butanoate Methyl 4-(Chlorocarbonyl)butyrate METHYL 4-(CHLOROFORMYL)BUTYRATE METHYL 5-CHLORO-5-OXOVALERATE METHYL GLUTARYL CHLORIDE GLUTARIC ACID MONOMETHYL ESTER CHLORIDE CARBOMETHOXYL BUTYRYL CHLORIDE 5-CHLORO-5-OXOPENTANOIC ACID METHYL ESTER 5-chloro-5-oxo-pentanoicacimethylester METHYL 5-CHLORO-5-OXOVALERATE,98% Methyl glutarylchloride(Methyl 4-chloro -oxovalerate) Pentanoic acid, 5-chloro-5-oxo-, methyl ester Methyl 4-(chloroformyl)-butyrate 98 % Methyl 4-(chloroformyl)butyrate, Methyl 5-chloro-5-oxovalerate, Methyl glutaryl chloride 5-Oxo-5-chloropentanoic acid methyl ester 5-Oxo-5-methoxypentanoic acid chloride Glutaric acid MonoMethyl ester chlo Methyl 4-(chloroform Glutaric acid monomethyl ester chloride 98% METHYL 4-(CHLOROFORMYL)BUTYRATE 1501-26-4 Methyl 5-chloro-5- METHYL 5-CHLORO-5-OXOPENTANOATE 1501-26-4 ClCOCH23CO2CH3 ClCOCH23COOCH3 ACID CHLORIDE Building Blocks Carbonyl Compounds Acid Halides Organic Building Blocks Acid Halides Building Blocks Carbonyl Compounds Chemical Synthesis Organic Building Blocks API intermediates Halogen compounds