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IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE

CAS No.
6188-43-8
Chemical Name:
IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
Synonyms
Minodronic Acid Impurity 30;[1,2-α]PYRIDIN-3-CARBOXALDEHYDE;Imidazo[1,2-a]pyridine-3-carbaldehyde;imidazo[3,2-a]pyridine-3-carbaldehyde;3-imidazo[3,2-a]pyridinecarboxaldehyde;IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE;IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE;Imidazo[1,2-a]pyridine-3-carbaldehyde AldrichCPR;Imidazo[1,2-a]pyridine-3-carboxaldehyde (7CI, 8CI, 9CI, ACI)
CBNumber:
CB4483670
Molecular Formula:
C8H6N2O
Molecular Weight:
146.15
MDL Number:
MFCD07778354
MOL File:
6188-43-8.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51
Product description Number Pack Size Price
Imidazo[1,2-a]pyridine-3-carbaldehyde I387593 500mg $175
Imidazo[1,2-a]pyridine-3-carbaldehyde 040365 500mg $252
Imidazo[1,2-a]pyridine-3-carbaldehyde 98% OR909920 5g $330
Imidazo[1,2-a]pyridine-3-carbaldehyde 98% OR909920 10g $565
Imidazo[1,2-a]pyridine-3-carbaldehyde 98% OR909920 1g $115
More product size

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Properties

Melting point 127-129 °C
Density 1.24±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 4.15±0.50(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
HazardClass  IRRITANT
HS Code  2933998090

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC I387593 Imidazo[1,2-a]pyridine-3-carbaldehyde 6188-43-8 500mg $175 2021-12-16 Buy
Matrix Scientific 040365 Imidazo[1,2-a]pyridine-3-carbaldehyde 6188-43-8 500mg $252 2021-12-16 Buy
Apolloscientific OR909920 Imidazo[1,2-a]pyridine-3-carbaldehyde 98% 6188-43-8 5g $330 2021-12-16 Buy
Apolloscientific OR909920 Imidazo[1,2-a]pyridine-3-carbaldehyde 98% 6188-43-8 10g $565 2021-12-16 Buy
Apolloscientific OR909920 Imidazo[1,2-a]pyridine-3-carbaldehyde 98% 6188-43-8 1g $115 2021-12-16 Buy
Product number Packaging Price Buy
I387593 500mg $175 Buy
040365 500mg $252 Buy
OR909920 5g $330 Buy
OR909920 10g $565 Buy
OR909920 1g $115 Buy

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Chemical Properties,Uses,Production

Synthesis

Imidazo[1,2-a]pyridine

274-76-0

N,N-Dimethylformamide

68-12-2

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE

6188-43-8

Freshly distilled phosphorus trichloride (61 mL, 0.65 mol) was slowly added to N,N-dimethylformamide (120 mL, 1.55 mol) at 2 °C. After controlling the reaction temperature to gradually increase to room temperature, the reaction system was again cooled to 2 °C. Subsequently, a solution of N,N-dimethylformamide (60 mL) of imidazo[1,2-a]pyridine (10 g, 0.085 mol) was added dropwise. The reaction mixture was slowly warmed to 105 °C, followed by further warming to 140 °C. The reaction temperature was stabilized at 120 °C by removing the oil bath. Heating was continued at this temperature for 45 minutes, after which the temperature was reduced to 85 °C and continued for 2.5 hours. Upon completion of the reaction, the mixture was cooled and poured into ice-cooled 5% hydrochloric acid (600 mL) and the pH was adjusted with 20% sodium hydroxide solution to 9. The resulting solution was extracted with dichloromethane (1200 mL) overnight. The organic layer was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was washed with water (5 x 15 mL) and dried again to give 3.49 g of imidazo[1,2-a]pyridine-3-carbaldehyde in 31% yield.

References

[1] Farmaco, Edizione Scientifica, 1981, vol. 36, # 12, p. 994 - 1003
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3454 - 3464
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 10, p. 4820 - 4826
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859
[5] Patent: WO2005/66132, 2005, A1. Location in patent: Page/Page column 89-90

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Preparation Products And Raw materials

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View Lastest Price from IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Imidazo[1,2-a]pyridine-3-carbaldehyde pictures 2025-10-13 Imidazo[1,2-a]pyridine-3-carbaldehyde
6188-43-8
US $1.60-6.60 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE pictures 2020-01-10 IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
6188-43-8
US $1.00 / g 1g 99.0% 100kg Career Henan Chemical Co

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Spectrum

imidazo[3,2-a]pyridine-3-carbaldehyde IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE [1,2-α]PYRIDIN-3-CARBOXALDEHYDE Imidazo[1,2-a]pyridine-3-carbaldehyde Imidazo[1,2-a]pyridine-3-carbaldehyde AldrichCPR 3-imidazo[3,2-a]pyridinecarboxaldehyde Imidazo[1,2-a]pyridine-3-carboxaldehyde (7CI, 8CI, 9CI, ACI) Minodronic Acid Impurity 30 6188-43-8 6168-43-8 blocks Imidazoles Pyridines