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4-Nitro-3-trifluoromethyl aniline

4-Nitro-3-trifluoromethyl aniline Structure
4-Nitro-3-trifluoromethyl aniline structure
CAS No.
393-11-3
Chemical Name:
4-Nitro-3-trifluoromethyl aniline
Synonyms
FLU-1;4-Nitro-α,α,α;TIMTEC-BB SBB006652;Flutamide Impurity A;Nilutamide Impurity 3;Nilutamide impurity B CRS;FlutaMide Related CoMpound A;Linagliptin Impurity CD10103;2-Nitro-5-aminobenzotriluoride;5-AMINO-2-NITROBENZOTRIFLUORIDE
CBNumber:
CB4483928
Molecular Formula:
C7H5F3N2O2
Molecular Weight:
206.12
MDL Number:
MFCD00014717
MOL File:
393-11-3.mol
MSDS File:
SDS
Last updated:2025-09-18 19:10:02
Product description Number Pack Size Price
Nilutamide impurity B European Pharmacopoeia (EP) Reference Standard Y0000894 5 mg $118
4-Nitro-3-(trifluoromethyl)aniline 98% A68807 5g $103.6
Flutamide Related Compound A United States Pharmacopeia (USP) Reference Standard 1285997 20mg $1300
5-Amino-2-nitrobenzotrifluoride >98.0%(GC) A0377 5g $18
5-Amino-2-nitrobenzotrifluoride >98.0%(GC) A0377 25g $60
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4-Nitro-3-trifluoromethyl aniline Properties

Melting point 125-129 °C (lit.)
Boiling point 326.4±42.0 °C(Predicted)
Density 1.4711 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka -0.22±0.10(Predicted)
color Yellow to Orange-Yellow
BRN 2650702
InChI InChI=1S/C7H5F3N2O2/c8-7(9,10)5-3-4(11)1-2-6(5)12(13)14/h1-3H,11H2
InChIKey UTKUVRNVYFTEHF-UHFFFAOYSA-N
SMILES C1(N)=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1
CAS DataBase Reference 393-11-3(CAS DataBase Reference)
FDA UNII 15YY91105I
NIST Chemistry Reference 5-Amino-2-nitrobenzotrifluoride(393-11-3)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36-36/37
WGK Germany  2
Hazard Note  Irritant
HS Code  29214200
NFPA 704
1
2 0

4-Nitro-3-trifluoromethyl aniline price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000894 Nilutamide impurity B European Pharmacopoeia (EP) Reference Standard 393-11-3 5 mg $118 2025-07-31 Buy
Sigma-Aldrich A68807 4-Nitro-3-(trifluoromethyl)aniline 98% 393-11-3 5g $103.6 2025-07-31 Buy
Sigma-Aldrich 1285997 Flutamide Related Compound A United States Pharmacopeia (USP) Reference Standard 393-11-3 20mg $1300 2025-07-31 Buy
TCI Chemical A0377 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) 393-11-3 5g $18 2025-07-31 Buy
TCI Chemical A0377 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) 393-11-3 25g $60 2025-07-31 Buy
Product number Packaging Price Buy
Y0000894 5 mg $118 Buy
A68807 5g $103.6 Buy
1285997 20mg $1300 Buy
A0377 5g $18 Buy
A0377 25g $60 Buy

4-Nitro-3-trifluoromethyl aniline Chemical Properties,Uses,Production

Description

4-Nitro-3-trifluoromethyl aniline is an organic intermediate, which can be used to prepare 4-bromo-2-nitrotrifluorotoluene, an intermediate of medicine and optical waveguide materials, and flutamide, a non steroidal anti androgen drug.

Chemical Properties

Orange to Brown to Dark red powder to crystal.

Uses

A metabolite of Flutamide (FLU-1 or M2).

Uses

4-Nitro-3-(trifluoromethyl)aniline is a metabolite of Flutamide (F598850) (FLU-1 or M2).

Synthesis

The thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of 1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in degassed THF (0.50 mL) under argon at r.t. The resulting suspension was stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in one portion, and the mixture was stirred (Table 2). Water (2 mL) was added, and the products were extracted with EtOAc (2 ?á 2 mL), the combined organic phase was dried over anhyd MgSO4, filtered, and concentrated in vacuo. Purification was achieved by passing the resulting residue through a short pad of silica (eluting with 50% light PE-EtOAc) unless otherwise stated.
4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 ??C (lit., 92-93 ??C); IR (FTIR, CHCl3) |ímax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.
Synthesis_393-11-3
Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline

4-Nitro-3-trifluoromethyl aniline synthesis

351-36-0
393-11-3
Synthesis of 4-Nitro-3-trifluoromethyl aniline from 3-(TRIFLUOROMETHYL)ACETANILIDE

4-Nitro-3-trifluoromethyl aniline Preparation Products And Raw materials

Raw materials

2-nitro-3-(trifluoromethyl)aniline 2-Nitrobenzotrifluoride

Preparation Products

Flutamide HYDROXYFLUTAMIDE 2-(Trifluoromethyl)benzene-1,4-diamine 5-Bromo-2-nitrobenzotrifluoride

4-Nitro-3-trifluoromethyl aniline Suppliers

Global( 438)Suppliers
Supplier Tel Email Country ProdList Advantage
Dayang Chem (Hangzhou) Co.,Ltd.
+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8772 58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		+8613288715578 sales@sichuanzyyt.com China 12247 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5251 58
Anhui Zhongda Biotechnology Co., Ltd 		+8615689548120 linda@zhongda-biotech.com China 193 58
Hebei Junhua Import and Export Co., LTD 		+85259680964 junhua1@hb-junhua.com China 933 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21620 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Supplier Advantage
Dayang Chem (Hangzhou) Co.,Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Sichuan Zhuoyu Yantang Technology Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Hebei Junhua Import and Export Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58

Related articles

View Lastest Price from 4-Nitro-3-trifluoromethyl aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Nitro-3-trifluoromethyl aniline pictures 2025-10-14 4-Nitro-3-trifluoromethyl aniline
393-11-3
 US $0.00 / kg 1kg 99% 1000 Hebei Junhua Import and Export Co., LTD
4-NITRO-3-TRIFLUOROMETHYL ANILINE pictures 2025-10-11 4-NITRO-3-TRIFLUOROMETHYL ANILINE
393-11-3
 US $10.00 / kg 1kg 99% 100 Hebei Chuanghai Biotechnology Co., Ltd
4-Nitro-3-trifluoromethyl aniline pictures 2025-09-18 4-Nitro-3-trifluoromethyl aniline
393-11-3
 US $29.00 / mg 99.68% 10g TargetMol Chemicals Inc.

4-Nitro-3-trifluoromethyl aniline Spectrum

4-Nitro-3-trifluoromethyl aniline(393-11-3)MS4-Nitro-3-trifluoromethyl aniline(393-11-3)1HNMR4-Nitro-3-trifluoromethyl aniline(393-11-3)FT-IR4-Nitro-3-trifluoromethyl aniline(393-11-3)Raman4-Nitro-3-trifluoromethyl aniline(393-11-3)IR

393-11-3(4-Nitro-3-trifluoromethyl aniline)Related Search:

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4-NITRO-2-SULFOANILINE 2-Nitrotoluene 3-Aminobenzotrifluoride Benzotrifluoride Glycine
2-Methylbenzotrifluoride ALTRENOGEST Betaine 4'-Nitroacetanilide N-Methyl-4-nitroaniline
5-Fluoro-2-nitrotoluene 4-NITRODIAZOAMINOBENZENE 3-Fluorobenzotrifluoride

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4-Nitro-3-Triflouromethyl Aniline (Flutamide Intermediate) Flutamide ImpurityⅠ:4-Nitro-3-(trifluoromethyl)aniline α,α,α-Trifluoro-4-nitro-m-toluidine 4-nitro-3-(trifluoromethyl)benzeneamine Flutamide Impurity A 4-Nitro-α,α,α 4-Nitro-3-(trifluoromethyl)aniline (FLU-1) 5-Amino-2-nitrobenzotrifluoride, 4-Nitro-α,α,α-trifluoro-m-toluidine 4-nitro-3-(trifluoromethyl)benzenamine FLU-1 4-Nitro-3-(trifluoromethyl)aniline ,98% FlutaMide Related CoMpound A The 4- nitro-3- threetrifluoroMethylaniline 4-Nitro-4-(trifluoromethyl)aniline Flutamide Related Compound A (20 mg) (4-nitro-3-(trifluoromethyl)aniline) 4-Nitro-3-(trifluoromethyl)aniline 98% 2-NITRO-5-AMINO BENZOTRIFLUORIDE 5-AMINO-2-NITROBENZOTRIFLUORIDE 4-NITRO-3-(TRIFLUOROMETHYL)ANILINE 4-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE 3-AMINO-6-NITROBENZOTRIFLUORIDE TIMTEC-BB SBB006652 2-Nitro-5-aminobenzotriluoride Benzenamine, 4-nitro-3-(trifluoromethyl)- 4-Nitro-α,α,α-trifluoro-m-toluidine 3-Trifluoromethyl-4-nitroaniline 4-Nitro-3-(trifluoromethyl) aniline (3-Amino-6-nitrobenzotrifluoride) 4-Nitro-3-aminobenzotrifluoride 4-Nitro-3-trifluoromethylaniline(Flutamide impurity) 5-Amino-2-nitrobenzotrifluoride,97% 5-Amino-2-nitrobenzotrifluoride 98% 5-Amino-2-nitrobenzotrifluoride98% 2-NITRO-5-AMINOBENZOTRIFLUORIDE(3-TRIFLUOROMETHYL-4-NITROANILINE) 3-trifluoromethyl-4-nitroanilide 4-Nitro-3-(trifluormethyl)anilin 3-trifluoromethyl-4-nitroaniune 5-Amino-2-nitrobenzotrifluoride > Nilutamide impurity B CRS Nilutamide Impurity 3 4-NITRO-3-TRIFLUOROMETHYL ANILINE CAS NO 393-11-3 Flutamide Impurity 1 (Flutamide EP Impurity A) TIANFU-CHEM 4-Nitro-3-trifluoromethyl aniline Flutamide Related Compound A (4-nitro-3-(trifluoromethyl)aniline) (1285997) Flutamide USP Related Compound A Flutamide EP Impurity A（Nilutamide EP Impurity B） 4-nitro-3-(trifluoromethyl)aniline (nifeline) 4-Nitro-3-(trifluoromethyl0aniline Linagliptin Impurity CD10103 4-Nitro-3-trifluoromethyl aniline, 10 mM in DMSO 2-Nitro-5-Aminotrifluorotoluene 393-11-3 Organic Building Blocks Nitrogen Compounds C7 Amines Building Blocks Anilines, Aromatic Amines and Nitro Compounds Amines