ASP-4058
- CAS No.
- 952565-91-2
- Chemical Name:
- ASP-4058
- Synonyms
- ASP-4058;ASP 4058,ASP4058;1H-Benzimidazole, 6-[5-[3-(trifluoromethyl)-4-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]-1,2,4-oxadiazol-3-yl]-;(S)-3-(1H-Benzo[d]imidazol-6-yl)-5-(3-(trifluoromethyl)-4-((1,1,1-trifluoropropan-2-yl)oxy)phenyl)-1,2,4-oxadiazole
- CBNumber:
- CB44844484
- Molecular Formula:
- C19H12F6N4O2
- Molecular Weight:
- 442.31
- MDL Number:
- MFCD31813625
- MOL File:
- 952565-91-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ASP 4058 | CNB56591 | 1mg | $428.34 |
| ASP 4058 | CNB56591 | 2mg | $642.52 |
| ASP 4058 | CNB56591 | 5mg | $999.45 |
| ASP 4058 | CNB56591 | 10mg | $1427.8 |
| ASP 4058 | CNB56591 | 25mg | $2570 |
| Boiling point | 581.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.463±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 9.18±0.30(Predicted) |
| color | White to off-white |
| FDA UNII | 01J7526K2Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
ASP-4058 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CNB56591 | ASP 4058 | 952565-91-2 | 1mg | $428.34 | 2026-06-04 | Buy |
| Biosynth | CNB56591 | ASP 4058 | 952565-91-2 | 2mg | $642.52 | 2026-06-04 | Buy |
| Biosynth | CNB56591 | ASP 4058 | 952565-91-2 | 5mg | $999.45 | 2026-06-04 | Buy |
| Biosynth | CNB56591 | ASP 4058 | 952565-91-2 | 10mg | $1427.8 | 2026-06-04 | Buy |
| Biosynth | CNB56591 | ASP 4058 | 952565-91-2 | 25mg | $2570 | 2026-06-04 | Buy |
ASP-4058 Chemical Properties,Uses,Production
Uses
ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile[1].
in vivo
ASP4058 (p.o., daily for 21 days) reduces the clinical score in a dose-dependent manner and the cumulative clinical score from day 0 to 21 dpi at 0.03, 0.1 and 0.3 mg/kg are 15.5±1.48, 9.50±2.17 and 1.17±1.17, respectively, while that of vehicle-treated group is 15.5±0.619 in rats. ASP4058 prevents decreases in body weight of EAE rats[1].
ASP4058 (p.o., daily for day 12 to day 45) maintains the clinical score at a relatively low level and the cumulative clinical scores (18-45 dpi) among the groups treated with 0.1 and 0.3 mg/kg dosages are 6.90±2.85 and 5.60±2.21, respectively in mice. The ED50 values for ASP4058 is 0.063 mg/kg[1].
| Animal Model: | Male Lewis rats with an induction of EAE[1]. |
| Dosage: | 0.03, 0.1 or 0.3 mg/kg. |
| Administration: | Oral administration once daily for 21 days. |
| Result: | Reduced the clinical score in a dose-dependent manner and the cumulative clinical score. |
| Animal Model: | SJL mice immunized with PLP139-151 and boosted with pertussis toxin developed relapsing-remitting EAE[1]. |
| Dosage: | 0.1 and 0.3 mg/kg |
| Administration: | Oral administration once daily from day 12 to day 45. |
| Result: | Maintained the clinical score at a relatively low level and the cumulative clinical scores (18-45 dpi). |
References
[1] Rie Yamamoto, et al. ASP4058, a Novel Agonist for Sphingosine 1-Phosphate Receptors 1 and 5, Ameliorates Rodent Experimental Autoimmune Encephalomyelitis with a Favorable Safety Profile. PLoS One. 2014 Oct 27;9(10):e110819. DOI:10.1371/journal.pone.0110819
ASP-4058 Preparation Products And Raw materials
Raw materials
Preparation Products
ASP-4058 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9948 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 9459 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4334 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10336 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2912 | 58 |
