NAMPT inhibitor-linker 2
- CAS No.
- 2241014-82-2
- Chemical Name:
- NAMPT inhibitor-linker 2
- Synonyms
- NAMPT inhibitor-linker 2;Benzamide, 4-[4-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-1-piperazinyl]-N-[[2-fluoro-4-[[[(1S,2S)-2-(3-pyridinyl)cyclopropyl]carbonyl]amino]phenyl]methyl]-
- CBNumber:
- CB44845027
- Molecular Formula:
- C34H33FN6O5
- Molecular Weight:
- 624.66
- MDL Number:
- MFCD31813687
- MOL File:
- 2241014-82-2.mol
- MSDS File:
- SDS
NAMPT inhibitor-linker 2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RPD01482 | Nampt inhibitor-linker 2 | 2241014-82-2 | 5mg | $1769.6 | 2026-06-05 | Buy |
| Biosynth | RPD01482 | Nampt inhibitor-linker 2 | 2241014-82-2 | 10mg | $2831.4 | 2026-06-05 | Buy |
| Biosynth | RPD01482 | Nampt inhibitor-linker 2 | 2241014-82-2 | 25mg | $5308.75 | 2026-06-05 | Buy |
| Biosynth | RPD01482 | Nampt inhibitor-linker 2 | 2241014-82-2 | 50mg | $8494.5 | 2026-06-05 | Buy |
| ChemScene | CS-0047701 | NAMPT inhibitor-linker 2 99.35% | 2241014-82-2 | 5mg | $325 | 2026-06-04 | Buy |
NAMPT inhibitor-linker 2 Chemical Properties, Uses, Production
Uses
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
in vivo
ADC-4 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1].
| Animal Model: | Female scid-beige (SCID bg) mice[1] |
| Dosage: | 20 mg/kg |
| Administration: | A single intravenous injection (i.v.) for 28 days |
| Result: | Significantly inhibited the growth of tumor in mice. |
IC 50
Traditional Cytotoxic Agents
References
[1] Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842. DOI:10.1021/acsmedchemlett.8b00254
NAMPT inhibitor-linker 2 Preparation Products And Raw materials
Raw materials
Preparation Products
NAMPT inhibitor-linker 2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-025-66113011 15955137747 | cb5@aikonchem.com | China | 10354 | 58 |
| SuZhou GoodChemTech Co., Ltd | 18136139868; 18136139868 | jinlun@goodchemtech.cn | China | 321 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
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