Pomalidomide-PEG6-Alkyne
- CAS No.
- Chemical Name:
- Pomalidomide-PEG6-Alkyne
- Synonyms
- Pomalidomide-PEG6-Alkyne
- CBNumber:
- CB44846367
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Pomalidomide-PEG6-Alkyne Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-PEG6-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitability
reaction type: click chemistry
reagent type: ligand-linker conjugate
Pomalidomide-PEG6-Alkyne Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-PEG6-Alkyne Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
