BRL 50481
- CAS No.
- 433695-36-4
- Chemical Name:
- BRL 50481
- Synonyms
- -50481;BRL 50481;BRL-50481 ，S5837;BRL-50481 (BRL50481;BRL-50481, Selective PDE7 inhibitor;5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
- CBNumber:
- CB4485083
- Molecular Formula:
- C9H12N2O4S
- Molecular Weight:
- 244.27
- MDL Number:
- MFCD03039912
- MOL File:
- 433695-36-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BRL 50481 ≥98% (HPLC), solid | B0936 | 5mg | $215 |
| BRL 50481 ≥98% (HPLC), solid | B0936 | 25mg | $639 |
| N,N,2-Trimethyl-5-nitrobenzenesulfonamide >98.0%(HPLC)(N) | T3112 | 200mg | $32 |
| N,N,2-Trimethyl-5-nitrobenzenesulfonamide >98.0%(HPLC)(N) | T3112 | 1g | $94 |
| BRL 50481 ≥98% | 16899 | 5mg | $49 |
| Melting point | 65-67°C |
|---|---|
| Boiling point | 391.1±52.0 °C(Predicted) |
| Density | 1.334±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 12 mg/mL |
| pka | -5+-.0.70(Predicted) |
| form | solid |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | 1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3 |
| InChIKey | IFIUFCJFLGCQPH-UHFFFAOYSA-N |
| SMILES | CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O |
| FDA UNII | 03G869PR3P |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| HS Code | 2935.90.9500 |
| Storage Class | 11 - Combustible Solids |
BRL 50481 price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B0936 | BRL 50481 ≥98% (HPLC), solid | 433695-36-4 | 5mg | $215 | 2026-04-30 | Buy |
| Sigma-Aldrich | B0936 | BRL 50481 ≥98% (HPLC), solid | 433695-36-4 | 25mg | $639 | 2026-04-30 | Buy |
| TCI Chemical | T3112 | N,N,2-Trimethyl-5-nitrobenzenesulfonamide >98.0%(HPLC)(N) | 433695-36-4 | 200mg | $32 | 2026-04-30 | Buy |
| TCI Chemical | T3112 | N,N,2-Trimethyl-5-nitrobenzenesulfonamide >98.0%(HPLC)(N) | 433695-36-4 | 1g | $94 | 2026-04-30 | Buy |
| Cayman Chemical | 16899 | BRL 50481 ≥98% | 433695-36-4 | 5mg | $49 | 2026-04-30 | Buy |
BRL 50481 Chemical Properties,Uses,Production
Description
BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2BRL-50481 increases mineralization in osteoblasts differentiated from hMSC.3Cell permeable.
Chemical Properties
Off-White Solid
Uses
A PDE7 inhibitor that has acceptable selectivity for in vivo studies
Definition
ChEBI: BRL-50481 is a C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM). It has a role as an EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor, a geroprotector and a bone density conservation agent. It is a sulfonamide, a C-nitro compound and a member of toluenes.
Biological Activity
Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (K i = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
Biochem/physiol Actions
BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).
storage
Store at +4°C
References
[1] SUSAN J SMITH. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.[J]. Molecular Pharmacology, 2004, 66 6: 1679-1689. DOI:10.1124/mol.104.002246
[2] LINGZHI ZHANG. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 19532-19537. DOI:10.1073/pnas.0806152105
[3] MINNA PEKKINEN . Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts[J]. Bone, 2008, 43 1: Pages 84-91. DOI:10.1016/j.bone.2008.02.021
BRL 50481 Preparation Products And Raw materials
Raw materials
Preparation Products
BRL 50481 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 | contact@trustwe.com | China | 5742 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18114 | 58 |
View Lastest Price from BRL 50481 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | BRL-50481
433695-36-4
|
$50.00-126.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | BRL 50481
433695-36-4
|
1KG | 98% | 20Tons | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-12-27 | BRL 50481
433695-36-4
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
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