Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide Structure
N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide structure
CAS No.
1816989-16-8
Chemical Name:
N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide
Synonyms
SY-1365;Mevociclib;Mevociclib，SY-1365;SY-1365;SY 1365;SY1365;N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide;N-[(1S,3R)-3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-1-methylcyclohexyl]-5-[(2E)-4-(dimethylamino)but-2-enamido]pyridine-2-carboxamide;N-[(1S,3R)-3-[[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-methylcyclohexyl]-5-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-2-pyridinecarboxamide;Inhibitor,triple negative breast cancer,TNBC,Mevociclib,Cyclin dependent kinase,SY1365,tumors,cancers,cell,inhibit,solid,CDK,small,SY 1365,CDK7/CycH/MAT1,lung;2-Pyridinecarboxamide, N-[(1S,3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-methylcyclohexyl]-5-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-
CBNumber:
CB44869298
Molecular Formula:
C31H35ClN8O2
Molecular Weight:
587.11
MDL Number:
MOL File:
1816989-16-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide Properties

Density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (212.90 mM)
form Solid
pka 12.04±0.70(Predicted)
color White to off-white
FDA UNII 704LW082GI

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth RXC98916 Mevociclib 1816989-16-8 10mg $986.4 2026-06-05 Buy
Biosynth RXC98916 Mevociclib 1816989-16-8 25mg $1608.25 2026-06-05 Buy
Biosynth RXC98916 Mevociclib 1816989-16-8 50mg $2572.5 2026-06-05 Buy
ChemScene CS-0095954 Mevociclib 99.73% 1816989-16-8 1mg $180 2026-06-04 Buy
ChemScene CS-0095954 Mevociclib 99.73% 1816989-16-8 5mg $379 2026-06-04 Buy
Product number Packaging Price Buy
RXC98916 10mg $986.4 Buy
RXC98916 25mg $1608.25 Buy
RXC98916 50mg $2572.5 Buy
CS-0095954 1mg $180 Buy
CS-0095954 5mg $379 Buy

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide Chemical Properties, Uses, Production

Uses

N-[(1S,3R)-3-[[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-methylcyclohexyl]-5-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-2-pyridinecarboxamide is a CDK7 inhibitor and is used for anticancer treatments.

in vivo

Mevociclib (20mg/kg; i.v.; biw; for 35 days) inhibits tumor growth in TNBC in vivo models[2].
Mevociclib induces unique transcriptional signature[2].

Animal Model:Mice, HCC70 xenograft model[2]
Dosage:20 mg/kg
Administration:Intravenous injection, twice weekly, for 35 days
Result:Inhibited tumor volume in vivo.

IC 50

CDK7

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide Suppliers

Global Suppliers ( 37)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 sales@adobechem.com China 1250 50
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4083 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9869 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Hubei Guangao Biotechnology Co., Ltd 027-02702759223056 18162699093 1208480011@qq.com China 9513 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai YuanQi Biotechnology Co., Ltd. 50
Amadis Chemical Company Limited 58
TargetMol Chemicals Inc. 58
InvivoChem 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
cjbscvictory 58
Hubei Guangao Biotechnology Co., Ltd 58

View Latest Price from N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mevociclib pictures 2026-07-27 Mevociclib
1816989-16-8
 $199.00 98.02% 10g TargetMol Chemicals Inc.
Mevociclib pictures 2026-07-27 Mevociclib
1816989-16-8
 $199.00 98.02% 10g TargetMol Chemicals Inc.
  • Mevociclib pictures
  • Mevociclib
    1816989-16-8
  • $199.00
  • 98.02%
  • TargetMol Chemicals Inc.
  • Mevociclib pictures
  • Mevociclib
    1816989-16-8
  • $199.00
  • 98.02%
  • TargetMol Chemicals Inc.

1816989-16-8 (N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide) Related Search:

CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) OTS964 hydrochloride GSK-3326595 DRB
Roscovitine

1of2

N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcyclohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide SY-1365;SY 1365;SY1365 2-Pyridinecarboxamide, N-[(1S,3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-methylcyclohexyl]-5-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]- N-[(1S,3R)-3-[[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-methylcyclohexyl]-5-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-2-pyridinecarboxamide Mevociclib，SY-1365 Inhibitor,triple negative breast cancer,TNBC,Mevociclib,Cyclin dependent kinase,SY1365,tumors,cancers,cell,inhibit,solid,CDK,small,SY 1365,CDK7/CycH/MAT1,lung N-[(1S,3R)-3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-1-methylcyclohexyl]-5-[(2E)-4-(dimethylamino)but-2-enamido]pyridine-2-carboxamide Mevociclib SY-1365 1816989-16-8 C31H35ClN8O2 SY-1365