Bispyrithione
- CAS No.
- 3696-28-4
- Chemical Name:
- Bispyrithione
- Synonyms
- dipyrithione;OMDS;osy20;omadineds;NSC 84740;NSC 241716;NSC 677437;ipyrithione;BISPYRITHIONE;omadinedisulfide
- CBNumber:
- CB4500917
- Molecular Formula:
- C10H8N2O2S2
- Molecular Weight:
- 252.31
- MDL Number:
- MFCD00006197
- MOL File:
- 3696-28-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,2'-Dithiobis(pyridine-N-oxide) | 273686 | 1g | $366 |
| 2,2'-Dithiobis(pyridine-N-oxide) | 273686 | 2g | $509 |
| 2,2'-Dithiobis(pyridine-N-oxide) | 273686 | 5g | $694 |
| 2,2'-Dithiobis(pyridine-N-oxide) | 273686 | 10g | $947 |
| 2,2'-Dithiobis(pyridine-N-oxide) | 273686 | 25g | $1310 |
| More product size | |||
| Melting point | 200.5°C (rough estimate) |
|---|---|
| Boiling point | 582.8±25.0 °C(Predicted) |
| Density | 1.4423 (rough estimate) |
| refractive index | 1.5650 (estimate) |
| solubility | Methanol (Slightly), Water (Slightly, Heated, Sonicated) |
| form | solid |
| pka | -0.77±0.10(Predicted) |
| color | Gray or off-white paste |
| PH | 5.0-7.0(25°C,1%soln.) |
| Stability | Hygroscopic |
| Cosmetics Ingredients Functions | ANTIMICROBIAL |
| InChI | InChI=1S/C10H8N2O2S2/c13-11-7-3-1-5-9(11)15-16-10-6-2-4-8-12(10)14/h1-8H |
| InChIKey | ZHDBTKPXEJDTTQ-UHFFFAOYSA-N |
| SMILES | S(C1[N+]([O-])=CC=CC=1)SC1[N+]([O-])=CC=CC=1 |
| EWG's Food Scores | 1-3 |
| FDA UNII | 9L87N86R9A |
| EPA Substance Registry System | Dipyrithione (3696-28-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| TSCA | TSCA listed |
| HS Code | 2933399990 |
Bispyrithione price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 273686 | 2,2'-Dithiobis(pyridine-N-oxide) | 3696-28-4 | 1g | $366 | 2026-06-03 | Buy |
| Usbiological | 273686 | 2,2'-Dithiobis(pyridine-N-oxide) | 3696-28-4 | 2g | $509 | 2026-06-03 | Buy |
| Usbiological | 273686 | 2,2'-Dithiobis(pyridine-N-oxide) | 3696-28-4 | 5g | $694 | 2026-06-03 | Buy |
| Usbiological | 273686 | 2,2'-Dithiobis(pyridine-N-oxide) | 3696-28-4 | 10g | $947 | 2026-06-03 | Buy |
| Usbiological | 273686 | 2,2'-Dithiobis(pyridine-N-oxide) | 3696-28-4 | 25g | $1310 | 2026-06-03 | Buy |
Bispyrithione Chemical Properties,Uses,Production
Description
Bispyrithione is a pyrithione derivate used as bactericide and fungicide. The drug was marketed under the name Crimanex in the form of shampoo for the treatment of dandruff, however it is no longer available on the manufacturer website (Drossa Pharm . It is currently used as a pesticide.
Chemical Properties
beige to slightly grey powder and chunks
Uses
Bispyrithione can be used as an antibacterial; antifungal.
Application
Bispyrithione is a new antidandruff agent behind zinc pyrithione. It has similar chemical structure to zinc pyrithione, thus performs the same bactericidal property, with unique bactericidal actions, especially to mycetes, mild fungus and microzymes. It also can effectively disinfect oval bacil, candia albicans and other mycetes, while normal antimicrobials can't. It is not sensitive to metal ion and dissolves in water more easily than zinc pyrithione, which improves the compatibility and leads to best bactericidal effect. In 2-in-1 shampoo, it doesn't affect the pearly effect but enhance color stability.
Definition
ChEBI: Dipyrithione is a pyridinium ion.
Mechanism of action
Inhibits the LPS-induced up-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells.
Synthesis
1, drop into successively the 600g2-chloropyridine in the 5000ml four-hole boiling flask, 100g maleic and acid anhydrides, 600g hydrogen peroxide (35%) are opened to stir and are warmed up to 60 ℃ of successive reactions 12 hours, make 2-chloropyridine-N-oxide water solution.
2, the 2-chloropyridine that uses the 4000g2-methyl chloride to divide four extractions to make-N-oxide water solution merges extraction phase, and condensing crystal makes sterling 2-chloropyridine-N-oxide compound.
3, the 2-chloropyridine that purification is obtained-N-oxide compound, 430g sodium sulphite, the 2000g high purity water, drop into successively in the 5000ml four-hole boiling flask, open and stir, be warming up to 70 ℃, along with the carrying out of reaction added a part of yellow soda ash in good time, the PH of adjustment system is stabilized in 9～10, and reaction finishes 70 ℃ of insulations 2 hours, and insulation finishes to cool.Make the pyrithione sodium water solution.
4, use an amount of dilute sulphuric acid to adjust the PH to 2 of pyrithione sodium water solution system, separate out a large amount of white crystals.Filtrated stock cleans solid, namely gets pyrithione.
5, the pyrithione that the reaction of upper step is obtained, the 1000g ultrapure water drops in the plastic cup, the unlatching dispersed with stirring is even, then slowly splash into 220g hydrogen peroxide (35%), reaction is 1 hour about 50 ℃, make finished product Bispyrithione 497g (99.72%, five step of content overall yield of reaction: 74.6%).
Pesticide Type
Fungicide
Bispyrithione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUXI HONOR SHINE CHEMICAL CO.,LTD | +86-0510-83593312 +8613665125081 | sales@honorshinechem.com | China | 69 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3955 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2451 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7239 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5898 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 955 | 58 | |
| Hebei Binshare New Material Co. Ltd | +8618633865755 | china01@hbbinshare.com | CHINA | 942 | 58 |
View Lastest Price from Bispyrithione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-17 | Bispyrithione
3696-28-4
|
25Kg/Bag | 0.3 | 20tons | WUXI HONOR SHINE CHEMICAL CO.,LTD | ||
 |
2026-07-01 | Bispyrithione
3696-28-4
|
$3.00 | 1g | 99% | 300tons | Hebei Dangtong Import and export Co LTD | |
 |
2026-04-22 | Dipyrithione
3696-28-4
|
$31.00-70.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- Bispyrithione
3696-28-4
- $0.00
- 0.3
- WUXI HONOR SHINE CHEMICAL CO.,LTD
-
- Bispyrithione
3696-28-4
- $3.00
- 99%
- Hebei Dangtong Import and export Co LTD
-
- Dipyrithione
3696-28-4
- $31.00-70.00
- 99.90%
- TargetMol Chemicals Inc.
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