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ChemicalBook >> CAS DataBase List >>1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Structure
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- structure
CAS No.
2138300-40-8
Chemical Name:
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-
Synonyms
STING agonist-4;diABZI STING Agonist-2;STING agonist-4, 10 mM in DMSO;1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-;1H-Benzimidazole-5-carboxamide, 1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- (ACI);TMEM173,STING agonist-4,MPYS,Inhibitor,STING agonist 4,STING,Stimulator of Interferon Genes,inhibit,ERIS,STING agonist4,MITA;1-{4-[5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazol-1-yl]butyl}-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazole-5-carboxamide
CBNumber:
CB45479775
Molecular Formula:
C34H38N12O4
Molecular Weight:
678.74
MDL Number:
MFCD32197200
MOL File:
2138300-40-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:07
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1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Properties

Density 1.48±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: slightly soluble
form A solid
pka 11.97±0.43(Predicted)
color White to gray
InChIKey ICZSAXDKFXTSGL-UHFFFAOYSA-N
SMILES C(N1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21)CCCN1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 34088 diABZI STING Agonist 2 ≥98% 2138300-40-8 500μg $69 2026-04-30 Buy
Cayman Chemical 34088 diABZI STING Agonist 2 ≥98% 2138300-40-8 1mg $127 2026-04-30 Buy
Cayman Chemical 34088 diABZI STING Agonist 2 ≥98% 2138300-40-8 5mg $525 2026-04-30 Buy
Cayman Chemical 34088 diABZI STING Agonist 2 ≥98% 2138300-40-8 10mg $918 2026-04-30 Buy
Biosynth NKD30040 Sting agonist-4 2138300-40-8 10mg $584.8 2026-06-04 Buy
Product number Packaging Price Buy
34088 500μg $69 Buy
34088 1mg $127 Buy
34088 5mg $525 Buy
34088 10mg $918 Buy
NKD30040 10mg $584.8 Buy

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Chemical Properties, Uses, Production

Uses

STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function[1].

Biological Activity

STING agonist-4 is a stimulator of receptor agonists of the interferon gene (STING) with an apparent inhibition constant IC50 of 20 nM, It is a compound containing two symmetrically related aminobenzimidazoles (ABZI ) based compounds.

in vitro

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC 50 of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K d < /sub> ) of approximately 1.6 nM. It (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC 50 of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.

Cell Viability Assay

< td class="col1"> Result:
Cell Line: Human peripheral blood mononucl ear cells (PBMCs)
Concentration: 0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM
Incubation Time: 2 hours
Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β.

target

IC50: 20 nM (STING agonist-4)

References

[1] Ramanjulu JM et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Dec;564(7736):439-443. DOI:10.1038/s41586-018-0705-y

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Suppliers

Global Suppliers ( 40)
Supplier Tel Email Country ProdList Advantage
Suzhou Su Taike Biological Reagent Co., Ltd. 0512-0512-65884469 18352410772 seetech@126.com China 4 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4860 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Heze Development Zone chuangli Chemical Co., Ltd. 0530-+86-530-529 6766，+86-15666160102 15666160102 info@chuangli-chem.com China 849 55
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
Supplier Advantage
Suzhou Su Taike Biological Reagent Co., Ltd. 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Heze Development Zone chuangli Chemical Co., Ltd. 55
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
InvivoChem 58
BOC Sciences 58

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Spectrum

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-(2138300-40-8)1HNMR

2138300-40-8 (1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-) Related Search:

1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-(3-hydroxypropoxy)-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy- 1H-Benzimidazole-5-carboxamide, 2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1-[(2S)-2-hydroxy-2-phenylethyl]- NA 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-amino-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-, hydrochloride (1:2) Methanone, (2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)(1-ethyl-1H-pyrazol-5-yl)-
1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-amino-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-

1of2

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- STING agonist-4 TMEM173,STING agonist-4,MPYS,Inhibitor,STING agonist 4,STING,Stimulator of Interferon Genes,inhibit,ERIS,STING agonist4,MITA diABZI STING Agonist-2 1H-Benzimidazole-5-carboxamide, 1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- (ACI) 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide 1-{4-[5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazol-1-yl]butyl}-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazole-5-carboxamide STING agonist-4, 10 mM in DMSO 2138300-40-8 213830-40-8 C34H38N12O4