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ChemicalBook >> CAS DataBase List >>Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl-

Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl-

Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- Structure
Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- structure
CAS No.
1610610-48-4
Chemical Name:
Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl-
Synonyms
KDU731;KDU731,KDU-731;3-(4-Carbamoylphenyl)-N-(5-cyanopyridin-2-yl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamide;Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl-
CBNumber:
CB45512313
Molecular Formula:
C22H16N6O2
Molecular Weight:
396.4
MDL Number:
MOL File:
1610610-48-4.mol
Last updated:2025-08-21 22:16:43
Product description Number Pack Size Price
KDU731 98.00% CS-0028127 1mg $550
KDU731 98.00% CS-0028127 5mg $980
KDU731 98.00% CS-0028127 10mg $1500
Request For Quotation

Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- Properties

Density 1.36±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 83.33 mg/mL (210.22 mM)
form Solid
pka 15.78±0.50(Predicted)
color White to off-white

Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0028127 KDU731 98.00% 1610610-48-4 1mg $550 2021-12-16 Buy
ChemScene CS-0028127 KDU731 98.00% 1610610-48-4 5mg $980 2021-12-16 Buy
ChemScene CS-0028127 KDU731 98.00% 1610610-48-4 10mg $1500 2021-12-16 Buy
Product number Packaging Price Buy
CS-0028127 1mg $550 Buy
CS-0028127 5mg $980 Buy
CS-0028127 10mg $1500 Buy

Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- Chemical Properties,Uses,Production

Uses

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].

in vivo

KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2]. KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool[2].

Animal Model:6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts[1]
Dosage:7 or 10 mg/kg
Administration:Orally administration; 7 or 10 mg/kg; 16 days
Result:Resulted in significant reduction of oocyst shedding.
Animal Model:Neonatal calves with 5 x 107 oocysts[1]
Dosage:5 mg/kg
Administration:Orally administration; 5 mg/kg; every 12 hours for 7 days
Result:Resulted in significant reduction of oocyst shedding in treated calves in their stool.

IC 50

PI4K

References

[1] Ward HD, et al. New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis. Trends Parasitol. 2017 Sep;33(9):662-664. DOI:10.1016/j.pt.2017.07.004
[2] Manjunatha UH, et al. A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature. 2017 Jun 15;546(7658):376-380. DOI:10.1038/nature22337

Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 4714 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Fan De(Beijing) Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58

View Lastest Price from Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KDU731 pictures 2025-08-21 KDU731
1610610-48-4
 US $1520.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • KDU731 pictures
  • KDU731
    1610610-48-4
  • US $1520.00-1980.00 / mg
  • TargetMol Chemicals Inc.
Pyrazolo[1,5-a]pyridine-5-carboxamide, 3-[4-(aminocarbonyl)phenyl]-N-(5-cyano-2-pyridinyl)-N-methyl- KDU731 3-(4-Carbamoylphenyl)-N-(5-cyanopyridin-2-yl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamide KDU731,KDU-731 1610610-48-4