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K-Ras G12C-IN-4

K-Ras G12C-IN-4 Structure
K-Ras G12C-IN-4 structure
CAS No.
2376328-55-9
Chemical Name:
K-Ras G12C-IN-4
Synonyms
K-Ras G12C-IN-4;K-Ras G12C-IN-4, 10 mM in DMSO;Inhibitor,K Ras G12C IN 4,inhibit,Ras,K-Ras G-12C-IN-4,KRas G12CIN4;1H-Indole-1-acetamide, 5-chloro-2-cyclopropyl-3-[(3,4-dihydro-5-methoxy-2(1H)-isoquinolinyl)carbonyl]-7-methyl-N-[1-(1-oxo-2-propen-1-yl)-3-azetidinyl]-
CBNumber:
CB45540585
Molecular Formula:
C31H33ClN4O4
Molecular Weight:
561.07
MDL Number:
MFCD32263400
MOL File:
2376328-55-9.mol
Last updated:2025-04-17 18:22:24
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K-Ras G12C-IN-4 Properties

storage temp. Store at -20°C
solubility DMSO : 62.5 mg/mL (111.39 mM; ultrasonic and warming and heat to 60°C)
form Solid
color White to off-white

K-Ras G12C-IN-4 Chemical Properties,Uses,Production

Uses

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].

Biological Activity

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1]. K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1].K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].

References

[1]. Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308.

K-Ras G12C-IN-4 Preparation Products And Raw materials

Raw materials

Preparation Products

K-Ras G12C-IN-4 Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3503 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9800 58
Hebei Weite Medical Technology Co., Ltd 13180081292 contact@wetogethermed.com China 7979 58
JinOu Biomedical (Nanjing) Co., Ltd. 13000000000 jinoupharma@163.com China 11721 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Suzhou Haiben Pharmaceutical Co., Ltd 19353112242 1816280386@qq.com China 8045 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Hebei Weite Medical Technology Co., Ltd 58
JinOu Biomedical (Nanjing) Co., Ltd. 58
TargetMol Chemicals Inc. 58
Suzhou Haiben Pharmaceutical Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
K-Ras G12C-IN-4 1H-Indole-1-acetamide, 5-chloro-2-cyclopropyl-3-[(3,4-dihydro-5-methoxy-2(1H)-isoquinolinyl)carbonyl]-7-methyl-N-[1-(1-oxo-2-propen-1-yl)-3-azetidinyl]- Inhibitor,K Ras G12C IN 4,inhibit,Ras,K-Ras G-12C-IN-4,KRas G12CIN4 K-Ras G12C-IN-4, 10 mM in DMSO 2376328-55-9