POM121 Antibody
- CAS No.
- Chemical Name:
- POM121 Antibody
- Synonyms
- POM121 Antibody
- CBNumber:
- CB45675285
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
POM121 Antibody Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
The nuclear pore complex is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins. POM121, also referred to as nucleoporin Nup121, is a transmembrane nuclear protein that is an essential component of the NPC. POM121 expression is increased in aggressive, lethal prostate cancer and contributes to cancer progression and aggressiveness by enhancing the nuclear import of oncogenic transcription factors, such as E2F1, MYC, and GATA2, allowing for the upregulation of target genes. Elevated levels of POM121 have also been associated with poor outcome in patients with colorectal, lung, and laryngeal cancers, and it may serve as a prognostic biomarker for these cancer types.
References
[1] Raices, M. and D'Angelo, M.A. (2017) Curr Opin Cell Biol 46, 26-32.
[2] Xu, S. and Powers, M.A. (2009) Semin Cell Dev Biol 20, 620-30.
[3] Rodriguez-Bravo, V. et al. (2018) Cell 174, 1200-1215.e20.
[4] Wang, T. et al. (2020) Expert Rev Mol Diagn 20, 345-353.
[5] Zhang, S. et al. (2020) Genet Test Mol Biomarkers 24, 819-824.
[6] Zhao, R. et al. (2020) Histol Histopathol 35, 1285-1293.
POM121 Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
POM121 Antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 027-19371278702 18008634902 | 19384116026@163.com | China | 3008 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 58 |
