NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla
- CAS No.
- 1234510-46-3
- Chemical Name:
- NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla
- Synonyms
- TRV-120027;TRV027;Saralasin Impurity 1;NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla;Sar-Arg-Vla-Tyr-Ile-His-Pro-D-Ala-OH;D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
- CBNumber:
- CB45849303
- Molecular Formula:
- C43H67N13O10
- Molecular Weight:
- 926.07
- MDL Number:
- MFCD34469675
- MOL File:
- 1234510-46-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| TRV-120027 98.21% | CS-0109050 | 1mg | $87 |
| TRV-120027 98.21% | CS-0109050 | 5mg | $271 |
| TRV-120027 98.21% | CS-0109050 | 10mg | $433 |
| TRV-120027 >98% | AA01XGWN | 1mg | $124 |
| TRV-120027 >98% | AA01XGWN | 5mg | $313 |
| Density | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| pka | 3.70±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | J1J4P3PQZD |
NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0109050 | TRV-120027 98.21% | 1234510-46-3 | 1mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0109050 | TRV-120027 98.21% | 1234510-46-3 | 5mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0109050 | TRV-120027 98.21% | 1234510-46-3 | 10mg | $433 | 2026-06-04 | Buy |
| aablocks | AA01XGWN | TRV-120027 >98% | 1234510-46-3 | 1mg | $124 | 2026-06-01 | Buy |
| aablocks | AA01XGWN | TRV-120027 >98% | 1234510-46-3 | 5mg | $313 | 2026-06-01 | Buy |
NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla Chemical Properties,Uses,Production
Uses
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages -arrestins while blocking G-protein signaling[1]. TRV120027inducesacutecatecholaminesecretionthrough cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for theacute decompensated heart failure (ADHF) treatment[2].
in vivo
TRV120027 (intravenousinjection; 0.3 or 1.5 μg/kg per minute; infusion rate, 0.5 mL/min) when added to furosemide decreases cardiac preload and afterload, systemic and renal vascular resistances, and left ventricular external work while increasing cardiac output and renal blood flow. GFR and renal excretory function are maintained in canines with experimental HF[1].
| Animal Model: | Male mongrel dogs (weight, 20.5–30 kg)[1] |
| Dosage: | 0.3 or 1.5 μg/kg per minute; infusion rate, 0.5 mL/min |
| Administration: | Intravenousinjection |
| Result: | Resulted in dose-dependent vasodilation, increased cardiac contractility, and decreased myocardial oxygen consumption in dog. |
IC 50
AT1 Receptor
References
[1] Boerrigter G, et al. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.Circ Heart Fail. 2012 Sep 1;5(5):627-34. Epub 2012 Aug 13. DOI:10.1161/CIRCHEARTFAILURE.112.969220
[2] Liu CH, et al. Arrestin-biasedAT1RagonisminducesacutecatecholaminesecretionthroughTRPC3coupling.Nat Commun.2017 Feb 9;8:14335. DOI:10.1038/ncomms14335
NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla Preparation Products And Raw materials
Raw materials
Preparation Products
NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4733 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7858 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2446 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
View Lastest Price from NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | TRV-120027
1234510-46-3
|
10g | TargetMol Chemicals Inc. |
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- TRV-120027
1234510-46-3
- TargetMol Chemicals Inc.
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