4-Iodo-3-(trifluoromethyl)benzoic acid
- CAS No.
- 914636-20-7
- Chemical Name:
- 4-Iodo-3-(trifluoromethyl)benzoic acid
- Synonyms
- 5-Carboxy-2-iodobenzotrifluoride;4-Iodo-3-(trifluoromethyl)benzoic acid;4-Iodo-3-(trifluoromethyl)benzoicacid99%;Benzoic acid, 4-iodo-3-(trifluoromethyl)-;4-Iodo-3-(trifluoromethyl)benzoic acid 99%
- CBNumber:
- CB4654010
- Molecular Formula:
- C8H4F3IO2
- Molecular Weight:
- 316.02
- MDL Number:
- MFCD09258947
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| HS Code | 2916399090 |
4-Iodo-3-(trifluoromethyl)benzoic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC9306 | 4-Iodo-3-(trifluoromethyl)benzoic acid 98% | 914636-20-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC9306 | 4-Iodo-3-(trifluoromethyl)benzoic acid 98% | 914636-20-7 | 5g | $62 | 2026-06-04 | Buy |
| Apolloscientific | PC9306 | 4-Iodo-3-(trifluoromethyl)benzoic acid 98% | 914636-20-7 | 25g | $215 | 2026-06-04 | Buy |
| Activate Scientific | AS91328 | 4-Iodo-3-(trifluoromethyl)benzoic Acid 97% | 914636-20-7 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS91328 | 4-Iodo-3-(trifluoromethyl)benzoic Acid 97% | 914636-20-7 | 5g | $100 | 2026-06-04 | Buy |
4-Iodo-3-(trifluoromethyl)benzoic acid Chemical Properties,Uses,Production
Synthesis
400-76-0
914636-20-7
General procedure for the synthesis of 4-iodo-3-(trifluoromethyl)benzoic acid from 3-trifluoromethyl-4-aminobenzoic acid: 4-amino-3-trifluoromethylbenzoic acid (1.8 g, 8.8 mmol) was suspended in 30 mL of hydrochloric acid. An aqueous solution (15 mL) of sodium nitrite (0.76 g, 11.0 mmol) was slowly added dropwise at 0°C. The reaction mixture was stirred at 0-10 °C for 30 min. Subsequently, an aqueous solution (25 mL) of potassium iodide (14.6 g, 88 mmol) was added dropwise. The mixture was stirred at room temperature for 1 hour. After completion of the reaction, the product was extracted with ethyl acetate (80 mL) and the organic layer was washed with brine (80 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast chromatography using a gradient elution with ethyl acetate/hexane, resulting in 4-iodo-3-(trifluoromethyl)benzoic acid (2.4 g, 86% yield) as a solid.LC-ES/MS analysis showed m/e 339.3 (M+23) and 315.0 (M-1).
References
[1] Patent: WO2007/140174, 2007, A2. Location in patent: Page/Page column 42
4-Iodo-3-(trifluoromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Iodo-3-(trifluoromethyl)benzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Nanjing ShengSai Chemical Co., Ltd. | 025-85205967 13951876367 | shengsaichem@163.com | China | 818 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai CR Corporation Limited | 13917420128 13062833949 | fred.wen@crcorporation.cn | China | 9773 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Dandong Gilkuhn Import&Export Co., Ltd. | +86-519-83607890 18921087080 | China | 346 | 58 | |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 7994 | 58 |
| Shanghai SPAR pharmaceutical technology co., LTD | 021-000000 | admin@jingshipharmatech.com | China | 9919 | 58 |
