6-BROMO INDAZOLE-3-CARBOXYLIC ACID
- CAS No.
- 660823-36-9
- Chemical Name:
- 6-BROMO INDAZOLE-3-CARBOXYLIC ACID
- Synonyms
- 6-BroMo-1H-indazole-3-car...;6-Bromo-3-carboxy-1H-indazole;6-broMo-indazole-3-carboxylate;6-BROMO-3-INDAZOLECARBOXYLIC ACID;6-BROMO INDAZOLE-3-CARBOXYLIC ACID;6-Bromo-1H-indazole-3-carboxylicaci;6-Bromo-1H-indazol-3-carboxylic acid;Methyl 6-bromo indazole-3-carboxylate;6-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID;1H-Indazole-3-carboxylic acid, 6-bromo-
- CBNumber:
- CB4665676
- Molecular Formula:
- C8H5BrN2O2
- Molecular Weight:
- 241.04
- MDL Number:
- MFCD05663977
- MOL File:
- 660823-36-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
| RIDADR | UN2811 |
| HS Code | 2933998090 |
6-BROMO INDAZOLE-3-CARBOXYLIC ACID price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B683778 | 6-Bromo-1H-indazole-3-carboxylicAcid | 660823-36-9 | 100mg | $50 | 2021-12-16 | Buy |
| TRC | B683778 | 6-Bromo-1H-indazole-3-carboxylicAcid | 660823-36-9 | 500mg | $210 | 2021-12-16 | Buy |
| AK Scientific | W7715 | 6-Bromoindazole-3-carboxylicacid | 660823-36-9 | 250mg | $244 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H21-9-Z4 | 6-Bromo-1H-indazole-3-carboxylic acid 96% | 660823-36-9 | 1g | $290 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB11901 | 6-Bromo-1H-indazole-3-carboxylic acid | 660823-36-9 | 1g | $320 | 2021-12-16 | Buy |
6-BROMO INDAZOLE-3-CARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
6-Bromo-1H-indazole-3-carboxylic Acid is used in the synthesis of indazole derivatives as potent hepcidin production inhibitors for the treatment of anemia of chronic diseases (ACD).
Synthesis
6326-79-0
660823-36-9
General procedure for the synthesis of 6-bromoindazole-3-carboxylic acids from 6-bromodihydroindole-2,3-dione: The conversion of substituted indirubic acids to the corresponding indazole-3-carboxylic acids was carried out in essentially the same way as described by Snyder, H.R. et al. This was done as follows: first, the substituted indigo (22.1 mmol) was diluted with 1N sodium hydroxide solution (24 mL) and heated at 50 °C for 30 min. Subsequently, the resulting burgundy-colored solution was cooled to room temperature and kept for 1 hour. Next, the reaction mixture was cooled to 0 °C and treated with an aqueous solution (5.5 mL) of sodium nitrite (22.0 mmol) at 0 °C. The solution was slowly added via a pipette submerged below the surface of a vigorously stirred aqueous solution of sulfuric acid (2.3 mL) (45 mL) at 0°C. The addition process lasted for 15 min, after which the reaction mixture was held for an additional 30 min. Then, a cold (0°C) solution of concentrated hydrochloric acid (20 mL) of tin(II) chloride dihydrate (52.7 mmol) was added to the reaction mixture over a period of 10 minutes and the reaction mixture was held for 60 minutes. Upon completion of the reaction, the precipitated solid was separated by filtration, washed with water and dried to give a quantitative product. The product was of sufficient purity (confirmed by 1H NMR and LC/MS) to be used in the next step without further purification. Alternatively, the acid can be purified by recrystallization from acetic acid to obtain a higher purity substance. The following acids can also be prepared using this method: 6-bromo-1H-indazole-3-carboxylic acid, 5-methoxy-1H-indazole-3-carboxylic acid and 6-methoxy-1H-indazole-3-carboxylic acid.
References
[1] Patent: US2007/78147, 2007, A1. Location in patent: Page/Page column 63
[2] Patent: WO2004/14864, 2004, A1. Location in patent: Page 94
[3] Patent: WO2010/64875, 2010, A2. Location in patent: Page/Page column 17
[4] Patent: WO2011/20615, 2011, A1. Location in patent: Page/Page column 85; 86
[5] Patent: US2012/130069, 2012, A1. Location in patent: Page/Page column 8
6-BROMO INDAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29802 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
View Lastest Price from 6-BROMO INDAZOLE-3-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 6-BROMO INDAZOLE-3-CARBOXYLIC ACID
660823-36-9
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 6-BROMO INDAZOLE-3-CARBOXYLIC ACID
660823-36-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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