3'-Chloroacetophenone
- CAS No.
- 99-02-5
- Chemical Name:
- 3'-Chloroacetophenone
- Synonyms
- 1-(3-Chlorophenyl)ethan-1-one;1-(3-CHLOROPHENYL)ETHANONE;3-CHLOROACETOPHENONE;M-CHLOROACETOPHENONE;3'-Chloroacetophenon;3'-Chloroacetophenone;3'-Chloroacetylphenone;3a€?-Chloroacetophenone;1-Acetyl-3-chlorobenzene;3'-Chloroacetyl chloride
- CBNumber:
- CB4667827
- Molecular Formula:
- C8H7ClO
- Molecular Weight:
- 154.59
- MDL Number:
- MFCD00000593
- MOL File:
- 99-02-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3′-Chloroacetophenone 98% | 288799 | 5g | $28.5 |
| 3′-Chloroacetophenone 98% | 288799 | 25g | $33.2 |
| 3'-Chloroacetophenone >97.0%(GC) | C0096 | 10mL | $40 |
| 3'-Chloroacetophenone >97.0%(GC) | C0096 | 25mL | $79 |
| 3’-Chloroacetophenone | C363260 | 250g | $440 |
| More product size | |||
| Boiling point | 227-229 °C(lit.) |
|---|---|
| Density | 1.191 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 221 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.191 |
| Sensitive | Lachrymatory |
| BRN | 636318 |
| InChI | InChI=1S/C8H7ClO/c1-6(10)7-3-2-4-8(9)5-7/h2-5H,1H3 |
| InChIKey | UUWJBXKHMMQDED-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=CC(Cl)=C1)C |
| CAS DataBase Reference | 99-02-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetophenone, 3'-chloro-(99-02-5) |
| EPA Substance Registry System | Ethanone, 1-(3-chlorophenyl)- (99-02-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-36-20/21/22 | |||||||||
| Safety Statements | 26-36-37/39-36/37/39-13-7/9 | |||||||||
| RIDADR | UN 3416 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Harmful/Irritant/Lachrymatory | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29147090 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Excepted Quantities | Not Permitted as Excepted Quantity | |||||||||
| NFPA 704 |
|
3'-Chloroacetophenone price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 288799 | 3′-Chloroacetophenone 98% | 99-02-5 | 5g | $28.5 | 2026-03-19 | Buy |
| Sigma-Aldrich | 288799 | 3′-Chloroacetophenone 98% | 99-02-5 | 25g | $33.2 | 2026-03-19 | Buy |
| TCI Chemical | C0096 | 3'-Chloroacetophenone >97.0%(GC) | 99-02-5 | 10mL | $40 | 2026-03-19 | Buy |
| TCI Chemical | C0096 | 3'-Chloroacetophenone >97.0%(GC) | 99-02-5 | 25mL | $79 | 2026-03-19 | Buy |
| TRC | C363260 | 3’-Chloroacetophenone | 99-02-5 | 250g | $440 | 2021-12-16 | Buy |
3'-Chloroacetophenone Chemical Properties,Uses,Production
Uses
3'-Chloroacetophenone can be used as a raw material for pharmaceutical synthesis, mainly for the synthesis of carbamazepine, a drug for the treatment of epilepsy, and as an intermediate for fine chemicals, pesticides, etc.
Chemical Properties
clear colourless to yellow liquid
Uses
3’-Chloroacetophenone is usd in the synthesis of GABA-AT inhibitors. Also used in the synthesis of antimycobacterial studies.
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 2361, 1995 DOI: 10.1021/jo00113a013
General Description
The activity of strain, Saccharomyces cerevisiae B5, on the reduction of 3′-chloroacetophenone was studied.
Synthesis
The first step of the reaction is to use anhydrous ether as solvent, carbon tetrachloride as initiating catalyst, from magnesium, anhydrous ethanol and diethyl malonate, at atmospheric pressure and 20 ~ 35 , heating reflux for 2 ~ 4 hours, while the preparation of magnesium ethoxymalonate malonate diethyl ester, the conversion rate of diethyl malonate can reach 85% to 90%; the second step of the reaction is to use anhydrous ether as solvent, at atmospheric pressure and temperature 30 ~ 35 , and The second step reaction is to use anhydrous ether as solvent, at atmospheric pressure and temperature 30 ~ 35 , by the magnesium ethoxide malonate and m-chlorobenzoyl malonate reaction to generate m-chlorobenzoyl malonate, m-chlorobenzoyl conversion rate of 90%, the selectivity of up to 85%; the third step reaction is in the aqueous sulfuric acid solution, under atmospheric pressure and temperature of 90 ~ 110 , heated reflux for 3-5 hours by the hydrolysis and decarboxylation of m-chlorobenzoyl malonate and m-chlorophenyl acetophenone generation, hydrolysis and decarboxylation rate of almost 100%. The hydrolysis and decarboxylation rate was almost 100%. After hydrolysis and decarboxylation, the reaction mixture is separated by distillation, and m-chloroacetophenone with content 99% can be obtained, and the yield of the product can be up to 75%85%.
3'-Chloroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3996 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 3'-Chloroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 3'-Chloroacetophenone
99-02-5
|
US $0.00-0.00 / KG | 1KG | 99.0% | 1000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-15 | 3'-Chloroacetophenone
99-02-5
|
US $200.00-95.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2019-07-06 | 3'-Chloroacetophenone
99-02-5
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3'-Chloroacetophenone
99-02-5
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3'-Chloroacetophenone
99-02-5
- US $200.00-95.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- 3'-Chloroacetophenone
99-02-5
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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