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ChemicalBook >> CAS DataBase List >>3'-Fluoro-4'-hydroxyacetophenone

3'-Fluoro-4'-hydroxyacetophenone

3'-Fluoro-4'-hydroxyacetophenone Structure
3'-Fluoro-4'-hydroxyacetophenone structure
CAS No.
403-14-5
Chemical Name:
3'-Fluoro-4'-hydroxyacetophenone
Synonyms
BUTTPARK 153\33-64;3-FLUORO-4-HYDROXYACETOPHENONE;3'-Fluoro-4'-hydroxyacetophenone;3'-Fluoro-4'-hydroxyacetophenone>1-(3-FLUORO-4-HYDROXYPHENYL)ETHANONE;3'-Fluoro-4'-hydroxyacetophenone, 98+%;Ethanone, 1-(3-fluoro-4-hydroxyphenyl)-;1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE;1-(3-fluoro-4-hydroxyphenyl)ethan-1-one;1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (en)
CBNumber:
CB4675321
Molecular Formula:
C8H7FO2
Molecular Weight:
154.14
MDL Number:
MFCD00215840
MOL File:
403-14-5.mol
MSDS File:
SDS
Last updated:2026-01-13 11:21:45
Product description Number Pack Size Price
3′-Fluoro-4′-hydroxyacetophenone AldrichCPR CDS002790 100 mg $73.1
3'-Fluoro-4'-hydroxyacetophenone >97.0%(GC)(T) F0843 1g $59
3'-Fluoro-4'-hydroxyacetophenone >97.0%(GC)(T) F0843 5g $235
3''-Fluoro-4''-hydroxyacetophenone F597378 250mg $55
3''-Fluoro-4''-hydroxyacetophenone F597378 1g $75
More product size
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3'-Fluoro-4'-hydroxyacetophenone Properties

Melting point 127-129°C
Boiling point 125-135 °C(Press: 2 Torr)
Density 1.247±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 6.91±0.18(Predicted)
form powder to crystal
color Light yellow to Yellow to Orange
BRN 1936529
InChI 1S/C8H7FO2/c1-5(10)6-2-3-8(11)7(9)4-6/h2-4,11H,1H3
InChIKey GSWTXZXGONEVJC-UHFFFAOYSA-N
SMILES CC(=O)c1ccc(O)c(F)c1
CAS DataBase Reference 403-14-5(CAS DataBase Reference)
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  2914790090
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

3'-Fluoro-4'-hydroxyacetophenone price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS002790 3′-Fluoro-4′-hydroxyacetophenone AldrichCPR 403-14-5 100 mg $73.1 2025-07-31 Buy
TCI Chemical F0843 3'-Fluoro-4'-hydroxyacetophenone >97.0%(GC)(T) 403-14-5 1g $59 2025-07-31 Buy
TCI Chemical F0843 3'-Fluoro-4'-hydroxyacetophenone >97.0%(GC)(T) 403-14-5 5g $235 2025-07-31 Buy
TRC F597378 3''-Fluoro-4''-hydroxyacetophenone 403-14-5 250mg $55 2021-12-16 Buy
TRC F597378 3''-Fluoro-4''-hydroxyacetophenone 403-14-5 1g $75 2021-12-16 Buy
Product number Packaging Price Buy
CDS002790 100 mg $73.1 Buy
F0843 1g $59 Buy
F0843 5g $235 Buy
F597378 250mg $55 Buy
F597378 1g $75 Buy

3'-Fluoro-4'-hydroxyacetophenone Chemical Properties,Uses,Production

Uses

3''-Fluoro-4''-hydroxyacetophenone

Preparation

Preparation by reaction of pyridinium chloride on 3-fluoro-4- methoxyacetophenone at reflux (78%).

Synthesis

1-ACETOXY-2-FLUOROBENZENE

29650-44-0

2-Fluorophenol

367-12-4

3'-Fluoro-4'-hydroxyacetophenone

403-14-5

3''-Fluoro-2''-Hydroxyacetophenone

699-92-3

The mixture was heated to 120 °C with 2-fluorophenyl acetate (3,1.070 kg, 6.94 mol) and monochlorobenzene (5.34 L). Aluminum trichloride (1.39 kg, 10.42 mol) was added in batches over a period of 70-75 min at 120 °C, increasing the temperature by about 5 °C by controlling the rate of addition. The reaction was continued at the same temperature for 3 hours. Subsequently, the reaction mixture was cooled to 0-5 °C. Water (1.07 L) and 3.5% hydrochloric acid (2.14 L) were added sequentially under vigorous stirring using an ice bath to keep the internal temperature below 30 °C. The mixture was stirred vigorously at 5-10 °C for 1 h and then filtered, the solid filter cake was washed with water (1 L) and dried to give a beige solid, i.e., para-isomer 4 (416 g, 38.8% yield, HPLC purity >98%). The organic layer was separated from the filtrate and the organic layer was washed with water (2 L) and concentrated at atmospheric pressure to give the crude product (530 g), which was subsequently purified by steam distillation. The first part of the steam distillation was a liquid rich in 2-fluorophenol (45.2 g, LC analysis showed 70% 2-fluorophenol, 4% 4, 21% 5), and the second part was a light yellow solid, i.e., the neighboring isomer 5. The product 5 was separated by filtration, washed with water (80 mL), and then dried under vacuum to give the title compound (257.6 g, yield 24%, HPLC purity > 98.2%) as a light yellow solid. Steam distillation of the residue (HPLC analysis showed 92.7% 4, 3.63% 5) was crystallized by MTBE:hexane to give compound 4 (205.4 g, 19.2% yield, HPLC purity >98%).1H NMR (CDCl3, 400 MHz) data for 3-fluoro-4-hydroxyacetophenone (4): δ 7.75-7.67 (m, 2H, ArH), 7.06 (t, 1H, J = 8.4 Hz, ArH), 5.98 (d, 1H, J = 4 Hz, Ar-OH), 2.56 (s, 3H, Ac). m/z 153.00 was observed by LCMS. 1H NMR (CDCl3, 400 MHz) data of 3-fluoro-2-hydroxyacetophenone (5): δ 12.29 (s, 1H OH), 7.56-7.51 (m, 1H, ArH), 7.32-7.25 (m, 1H, ArH), 6.88-6.81 (m, 1H, ArH), 2.66 (s, 3H, CH3). m/z 153.00 observed by LCMS.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 15, p. 2426 - 2429

3'-Fluoro-4'-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

3''-Fluoro-2''-Hydroxyacetophenone 1-ACETOXY-2-FLUOROBENZENE Chlorobenzene Aluminum chloride

Preparation Products

2-Fluorophenol

3'-Fluoro-4'-hydroxyacetophenone Suppliers

Global( 213)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8754 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29837 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Xiamen Shindano Biotechnology Co.,ltd 		0592-6266840 15750707980 sales@chemsdano.com China 291 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Xiamen Shindano Biotechnology Co.,ltd 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 3'-Fluoro-4'-hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3'-Fluoro-4'-hydroxyacetophenone pictures 2026-01-05 3'-Fluoro-4'-hydroxyacetophenone
403-14-5
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
3'-Fluoro-4'-hydroxyacetophenone pictures 2024-04-23 3'-Fluoro-4'-hydroxyacetophenone
403-14-5
 US $100.00-30.00 / kg 1kg 99.93% 1000kg per week Ouhuang Engineering Materials (Hubei) Co., Ltd
3'-Fluoro-4'-hydroxyacetophenone pictures 2023-08-08 3'-Fluoro-4'-hydroxyacetophenone
403-14-5
 US $50.00 / kg 1kg 99.9% 10000MT Henan Bao Enluo International TradeCo.，LTD

3'-Fluoro-4'-hydroxyacetophenone Spectrum

3'-Fluoro-4'-hydroxyacetophenone(403-14-5)1HNMR

403-14-5(3'-Fluoro-4'-hydroxyacetophenone)Related Search:

4'-Hydroxyacetophenone 3'-Hydroxyacetophenone 2',4',6'-Trihydroxyacetophenone monohydrate 4'-(Trifluoromethyl)acetophenone 4-Fluoroacetophenone
4-Nitroacetophenone 3-Nitroacetophenone 2,4-Dihydroxyacetophenone 2'-Hydroxyacetophenone 2',6'-Dihydroxyacetophenone
3,5-Dihydroxyacetophenone 4'-Methylacetophenone Acetophenone 2-Bromoacetophenone 2-HYDROXYACETOPHENONE
3-FLUORO-4-HYDROXYPHENYLACETIC ACID Fluorine 3',5'-DIFLUORO-4'-HYDROXYPROPIOPHENONE

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1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 1-(3-FLUORO-4-HYDROXYPHENYL)ETHANONE 1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (en) 1-(3-fluoro-4-hydroxyphenyl)ethan-1-one BUTTPARK 153\33-64 3'-Fluoro-4'-hydroxyacetophenone, 98+% 3-FLUORO-4-HYDROXYACETOPHENONE 1-(3-Fluoro-4-hydroxyphenyl)ethan-1-one, 4-Acetyl-2-fluorophenol Ethanone, 1-(3-fluoro-4-hydroxyphenyl)- 3'-Fluoro-4'-hydroxyacetophenone> 3'-Fluoro-4'-hydroxyacetophenone 3′-Fluoro-4′-hydroxyacetophenone, CAS 403-14-5 403-14-5 Aromatic Acetophenones & Derivatives (substituted) Fluorine series Adehydes, Acetals & Ketones Fluorine Compounds Phenols