4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
- CAS No.
- 287930-73-8
- Chemical Name:
- 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
- Synonyms
- -2-hydroxymorphoL;Aprepitant Impurity 48;Fosaprepitant Impurity B;Fosaprepitant Impurity 23;4-Benzyl-2-hydroxy-3-morpholinone;4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE;4- benzyl -2- hydroxymorpholine -3- one;2-Hydroxy-4-(phenylMethyl)-3-Morpholinone;3-Morpholinone,2-hydroxy-4-(phenylMethyl)-;Aprepitant intermediates，4-Benzyl-2-hydroxy-morpholin-3-one
- CBNumber:
- CB4690014
- Molecular Formula:
- C11H13NO3
- Molecular Weight:
- 207.23
- MDL Number:
- MFCD07776435
- MOL File:
- 287930-73-8.mol
- MSDS File:
- SDS
| Melting point | 134.0 to 138.0 °C |
|---|---|
| Boiling point | 441.7±45.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 11.00±0.20(Predicted) |
| color | White to Off-White |
| optical activity | 0.30°(C=0.01g/ml CHCL3) |
| FDA UNII | DW732HYZ43 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| HS Code | 2934.99.4400 | |||||||||
| NFPA 704 |
|
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4918 | 4-Benzyl-2-hydroxymorpholin-3-one >98.0%(GC) | 287930-73-8 | 1g | $23 | 2025-07-31 | Buy |
| TCI Chemical | B4918 | 4-Benzyl-2-hydroxymorpholin-3-one >98.0%(GC) | 287930-73-8 | 5g | $65 | 2025-07-31 | Buy |
| TRC | H950915 | 2-Hydroxy-4-(phenylmethyl)-3-morpholinone | 287930-73-8 | 500mg | $145 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0361653 | 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE 95.00% | 287930-73-8 | 5MG | $500.32 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 58988 | 2-Hydroxy-4-(phenylmethyl)-3-morpholinone | 287930-73-8 | 5G | $2200 | 2021-12-16 | Buy |
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Chemical Properties,Uses,Production
Uses
2-Hydroxy-4-(phenylmethyl)-3-morpholinone, is an intermediate used for the synthesis of NK1 Receptor Antagonist Aprepitant (A729800), used as as antiemetic drugs.
Synthesis
298-12-4
104-63-2
287930-73-8
A 50% aqueous solution of glyoxalate (67 mL, 0.61 mol) and tetrahydrofuran (130 mL) were added to a 250 mL round bottom flask and heated to reflux. A solution of N-benzylethanolamine (41.5 g, 0.27 mol) in tetrahydrofuran (20 mL) was slowly added dropwise under reflux conditions. After completion of the reaction, the tetrahydrofuran solvent was removed by rotary evaporator. Water (170 mL) was added to the residue, stirred and cooled to room temperature, followed by continued stirring in an ice water bath for 30 min to promote crystallization. The precipitated solid was collected by filtration and washed with ice water. The resulting pale yellow solid was dried to afford the target product 4-benzyl-2-hydroxy-morpholin-3-one (compound of formula VII, 51.8 g, 91% yield) with a melting point of 132-136 °C.
References
[1] Patent: CN103030668, 2016, B. Location in patent: Paragraph 0031-0033
[2] Journal of the American Chemical Society, 2003, vol. 125, # 8, p. 2129 - 2135
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1014 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2953 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-17 | 287930-73-8
287930-73-8
|
US $100.00-60.00 / kg | 100kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD | |
 |
2025-07-08 | 4-Benzyl-2-hydroxy-3-morpholinone
287930-73-8
|
US $0.00-0.00 / KG | 1KG | 99% | 200 | Hangzhou ICH Biofarm Co., Ltd | |
 |
2023-09-07 | 4-Benzyl-2-hydroxy-3-morpholinone
287930-73-8
|
US $30.00 / kg | 1kg | 99% | 20 tons | Anhui Ruihan Technology Co., Ltd |
-
- 287930-73-8
287930-73-8
- US $100.00-60.00 / kg
- 99.99%
- Hebei Dangtong Import and export Co LTD
-
- 4-Benzyl-2-hydroxy-3-morpholinone
287930-73-8
- US $0.00-0.00 / KG
- 99%
- Hangzhou ICH Biofarm Co., Ltd
-
- 4-Benzyl-2-hydroxy-3-morpholinone
287930-73-8
- US $30.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd
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