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2,2-Dimethylsuccinic acid

2,2-Dimethylsuccinic acid Structure
2,2-Dimethylsuccinic acid structure
CAS No.
597-43-3
Chemical Name:
2,2-Dimethylsuccinic acid
Synonyms
Butanedioic acid, 2,2-dimethyl-;DiMethylsuccinic Aci;2,2-diMethyl succinate;2-DiMethylsuccinic acid;2,2-dimethylsuccinicaci;2,2-Dimethlsuccinic acid;2,2-DIMETHYLSUCCINIC ACID;3,3-Dimethylsuccinic acid;2,2-Dimethylbernsteinsure;2,2-DimethylsuccinicAcid>
CBNumber:
CB4697169
Molecular Formula:
C6H10O4
Molecular Weight:
146.14
MDL Number:
MFCD00004196
MOL File:
597-43-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-31 16:03:04
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2,2-Dimethylsuccinic acid Properties

Melting point 138-142 °C (lit.)
Boiling point 311.39°C (rough estimate)
Density 1.4528 (rough estimate)
refractive index 1.4328 (estimate)
storage temp. Sealed in dry,Room Temperature
pka 3.80±0.10(Predicted)
form powder to crystal
color White to Almost white
Water Solubility 70g/L(14 ºC)
BRN 1764476
InChI 1S/C6H10O4/c1-6(2,5(9)10)3-4(7)8/h3H2,1-2H3,(H,7,8)(H,9,10)
InChIKey GOHPTLYPQCTZSE-UHFFFAOYSA-N
SMILES CC(C)(CC(O)=O)C(O)=O
CAS DataBase Reference 597-43-3(CAS DataBase Reference)
FDA UNII MX6TVR2107
NIST Chemistry Reference 2,2-Dimethylbutanedioic acid(597-43-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HS Code  29171900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2,2-Dimethylsuccinic acid price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D186007 2,2-Dimethylsuccinic acid 99% 597-43-3 25g $148 2026-04-30 Buy
TCI Chemical D2184 2,2-Dimethylsuccinic Acid >98.0%(GC)(T) 597-43-3 5g $28 2026-04-30 Buy
TCI Chemical D2184 2,2-Dimethylsuccinic Acid >98.0%(GC)(T) 597-43-3 25g $83 2026-04-30 Buy
Usbiological 272984 2,2-Dimethylsuccinic Acid Asreported 597-43-3 25g $319 2026-06-03 Buy
Usbiological 272984 2,2-Dimethylsuccinic Acid Asreported 597-43-3 50g $439 2026-06-03 Buy
Product number Packaging Price Buy
D186007 25g $148 Buy
D2184 5g $28 Buy
D2184 25g $83 Buy
272984 25g $319 Buy
272984 50g $439 Buy

2,2-Dimethylsuccinic acid Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

Derivatives of 2,2-dimethylsuccinic acid serve as precursors for the synthesis of specific isoprenoids[1]. The compound acts as a starting material for synthesizing dimethyl 2,2-dimethylsuccinate via esterification with methanol and sulfuric acid, and serves as a ligand in the preparation of the bio-MOF Cu-AD-DMSA alongside copper nitrate and adenine[1][3]. It reacts with (PyH)5[MoOCl4(H2O)]3Cl2 in the presence of base to afford pyridinium salts of the [Mo2O4Cl4(μ2-dmsH)]3− complex[2].

Definition

ChEBI: An alpha,omega-dicarboxylic acid that is succinic acid substituted by two methyl groups at positions 2 and 2 respectively.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3418, 1949 DOI: 10.1021/ja01178a044
Synthesis, p. 710, 1980 DOI: 10.1055/s-1980-29181

Purification Methods

Crystallise the acid from EtOH/ether or EtOH/chloroform. [Beilstein 2 IV 1996.]

References

[1] Strunz, G. M., Ya, L. (1992). 2,2-Dimethylsuccinic acid derivatives in isoprenoid synthesis: a 2,2-dimethylvinyl anion equivalent in the synthesis of ar-atlantone, ar-turmerone, and prenylated aromatic compounds. Canadian Journal of Chemistry, 70(5), 1317–1322. https://doi.org/10.1139/v92-169
[2] Modec, B. (2013). Hydrogen-Bonding in Two Pyridinium Salts of [Mo2O4Cl4(μ2-dmsH)]3−Complex (dmsH− = a Half-Neutralized Form of 2,2-Dimethylsuccinic Acid). Crystals, 3(2), 275–288. https://doi.org/10.3390/cryst3020275
[3] Wang, Y., Zhang, F., Yang, Y., Wang, X., Li, L., Li, J., Yang, J. (2025). Optimizing the pore environment in biological metal–organic frameworks through the incorporation of hydrogen bond acceptors for inverse ethane/ethylene separation. Journal of Colloid and Interface Science, 687, 439–448. https://doi.org/10.1016/j.jcis.2025.02.088

2,2-Dimethylsuccinic acid synthesis

17347-61-4
105-13-5
597-43-3
Synthesis of 2,2-Dimethylsuccinic acid from 2,2-Dimethylsuccinic anhydride and 4-Methoxybenzyl alcohol

2,2-Dimethylsuccinic acid Preparation Products And Raw materials

Raw materials

Cyclopropanecarboxylic acid, 2,2-dimethoxy-3,3-dimethyl-, ethyl ester 3-cyano-3,3-dimethylpropanoic acid 2,2-Dimethylsuccinic anhydride Trimethylacetonitrile 4-Methoxybenzyl alcohol

Preparation Products

1,4-diethyl 2,2-dimethylbutanedioate

2,2-Dimethylsuccinic acid Suppliers

Global( 275)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57

View Lastest Price from 2,2-Dimethylsuccinic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,2-Dimethylsuccinic acid pictures 2025-06-27 2,2-Dimethylsuccinic acid
597-43-3
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
2,2-Dimethylsuccinic acid pictures 2022-02-23 2,2-Dimethylsuccinic acid
597-43-3
 1KG 99.4% 100 tons Honest Joy Holdings Limited
2,2-Dimethylsuccinic acid pictures 2019-07-06 2,2-Dimethylsuccinic acid
597-43-3
 $1.00 1kg 95%-99% Career Henan Chemical Co

2,2-Dimethylsuccinic acid Spectrum

2,2-Dimethylsuccinic acid(597-43-3)MS2,2-Dimethylsuccinic acid(597-43-3)1HNMR2,2-Dimethylsuccinic acid(597-43-3)13CNMR2,2-Dimethylsuccinic acid(597-43-3)IR12,2-Dimethylsuccinic acid(597-43-3)IR22,2-Dimethylsuccinic acid(597-43-3)Raman

597-43-3(2,2-Dimethylsuccinic acid )Related Search:

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2,2-DIMETHYLSUCCINIC ACID ANHYDRIDE 2,3-DIMETHYLSUCCINIC ACID 2-Methylsuccinic acid

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ALPHA,ALPHA-DIMETHYLSUCCINIC ACID 2,2-DIMETHYL-1,4-BUTANEDIOIC ACID 2,2-DIMETHYLSUCCINIC ACID Butanedioic acid, 2,2-dimethyl- Succinic acid, 2,2-dimethyl- 2,2-Dimethlsuccinic acid 2,2-dimethylbutanedioic acid 3,3-Dimethylsuccinic acid 2,2-Dimethylsuccinic acid,99% 2,2-diMethyl succinate 2-DiMethylsuccinic acid 2,2-Dimethylbutane-1,4-dioic acid 2,2-Dimethylsuccinic acid 99% DiMethylsuccinic Aci 2,2-Dimethylbernsteinsure 2,2-DimethylsuccinicAcid> 2,2-dimethylsuccinicaci 597-43-3 597-43-7 HOOCCH2CCH32COOH Building Blocks Carbonyl Compounds Carboxylic Acids Organic Building Blocks C6 Carbonyl Compounds Carboxylic Acids C6