3,5-Difluoro-2-nitrobenzoic acid
- CAS No.
- 331765-71-0
- Chemical Name:
- 3,5-Difluoro-2-nitrobenzoic acid
- Synonyms
- BUTTPARK 51\07-01;3,5-Difluoro-2-nitrobenzoic acid;2-Carboxy-4,6-difluoronitrobenzene;Benzoic acid, 3,5-difluoro-2-nitro-
- CBNumber:
- CB4720340
- Molecular Formula:
- C7H3F2NO4
- Molecular Weight:
- 203.1
- MDL Number:
- MFCD04035649
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P271 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2916399090 |
3,5-Difluoro-2-nitrobenzoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GNA76571 | 3,5-Difluoro-2-nitrobenzoic acid | 331765-71-0 | 10g | $354 | 2026-06-04 | Buy |
| Apolloscientific | PC0922 | 3,5-Difluoro-2-nitrobenzoic acid ≥95% | 331765-71-0 | 1g | $22 | 2026-06-04 | Buy |
| Apolloscientific | PC0922 | 3,5-Difluoro-2-nitrobenzoic acid ≥95% | 331765-71-0 | 5g | $82 | 2026-06-04 | Buy |
| Apolloscientific | PC0922 | 3,5-Difluoro-2-nitrobenzoic acid ≥95% | 331765-71-0 | 25g | $300 | 2026-06-04 | Buy |
| Apolloscientific | PC0922 | 3,5-Difluoro-2-nitrobenzoic acid ≥95% | 331765-71-0 | 100g | $908 | 2026-06-04 | Buy |
3,5-Difluoro-2-nitrobenzoic acid Chemical Properties, Uses, Production
Synthesis
455-40-3
331765-71-0
Step 1: 3,5-difluorobenzoic acid (80 g, 506 mmol) was stirred with concentrated sulfuric acid (250 mL) for 1 hour at room temperature. Subsequently, concentrated nitric acid (90 mL) was added slowly and dropwise while the reaction temperature was controlled below 45 °C by a water bath. The reaction mixture was stirred overnight at room temperature. The reaction was quenched by slowly pouring the reaction solution into crushed ice, the precipitated solid was collected by filtration and washed thoroughly with cold water to afford 3,5-difluoro-2-nitrobenzoic acid (compound 273) as a white solid (93.0 g, 91% yield). The product could be used directly in the subsequent reaction without further purification.1H NMR (400 MHz, DMSO-d6) δ 8.01 (ddd, J = 10.9, 8.5, 2.8 Hz, 1H), 7.71 (dt, J = 8.4, 2.2 Hz, 1H).
References
[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 234
[2] Patent: EP1214299, 2004, B1. Location in patent: Page 18
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 7, p. 2733 - 2743
3,5-Difluoro-2-nitrobenzoic acid Preparation Products And Raw materials
3,5-Difluoro-2-nitrobenzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Xinyanhe Pharmatech Co.,Ltd | 0519-85252752 15366845260 | taihuaren@vip.163.com | China | 1031 | 58 |
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| Quzhou AMK BioTech Co., Ltd | 0570-3081766 18357083060 | sales@qzamkbio.com | China | 1200 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
