3-AMINO-ISONICOTINIC ACID ETHYL ESTER
- CAS No.
- 14208-83-4
- Chemical Name:
- 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
- Synonyms
- 3-amino-4-pyridinecarboxyL;Ethyl3-Aminoisonicotinate>3-Amino-isonicotinic acid ethyl;ethyl 3-aMinopyridin-4-carboxylate;Ethyl3-amino-4-pyridinecarboxylate;ETHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;3-AMINO-ISONICOTINIC ACID ETHYL ESTER;Ethyl 3-aminoisopyridin-3-carboxylate;3-Amino-isonicotinic acid ethyl ester ,98%;Ethyl 3-aminoisonicotinate, CAS 14208-83-4
- CBNumber:
- CB4733551
- Molecular Formula:
- C8H10N2O2
- Molecular Weight:
- 166.18
- MDL Number:
- MFCD03788270
- MOL File:
- 14208-83-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl 3-Aminoisonicotinate >98.0%(GC)(T) | E1137 | 1g | $45 |
| Ethyl 3-Aminoisonicotinate >98.0%(GC)(T) | E1137 | 5g | $137 |
| 3-Aminoisonicotinicacidethylester | JK142958 | 1g | $250 |
| 3-Amino isonicotinic acid ethyl ester | FA51047 | 5G | $353.5 |
| 3-Amino isonicotinic acid ethyl ester | FA51047 | 10g | $565.6 |
| More product size | |||
| Melting point | 170-175 |
|---|---|
| Boiling point | 304.0±22.0 °C(Predicted) |
| Density | 1.192±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 4.13±0.18(Predicted) |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| CAS DataBase Reference | 14208-83-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| Hazard Note | Irritant |
| HS Code | 29339900 |
3-AMINO-ISONICOTINIC ACID ETHYL ESTER price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1137 | Ethyl 3-Aminoisonicotinate >98.0%(GC)(T) | 14208-83-4 | 1g | $45 | 2026-03-19 | Buy |
| TCI Chemical | E1137 | Ethyl 3-Aminoisonicotinate >98.0%(GC)(T) | 14208-83-4 | 5g | $137 | 2026-03-19 | Buy |
| Frontier Specialty Chemicals | JK142958 | 3-Aminoisonicotinicacidethylester | 14208-83-4 | 1g | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA51047 | 3-Amino isonicotinic acid ethyl ester | 14208-83-4 | 5G | $353.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA51047 | 3-Amino isonicotinic acid ethyl ester | 14208-83-4 | 10g | $565.6 | 2021-12-16 | Buy |
3-AMINO-ISONICOTINIC ACID ETHYL ESTER Chemical Properties,Uses,Production
Chemical Properties
Off-white powder or chunks solid
Uses
3-Amino-isonicotinic Acid Ethyl Ester acts as a reagent for the synthetic preparation of heteroaryl compounds as PDE-10 inhibitors useful in treatment and prevention of CNS, metabolic and other diseases. Also in the design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
Synthesis
64-17-5
7579-20-6
14208-83-4
To ethanol (20 mL) was added 3-aminoisonicotinic acid (1.4 g, 10 mmol) and stirred until completely dissolved. Concentrated sulfuric acid (2.94 g, 30 mmol) was added slowly and the reaction was heated to reflux for 20 hours. After completion of the reaction, ethanol was removed by distillation under reduced pressure. To the residue, water was added and the pH was adjusted to 8-9 with 2 N sodium hydroxide solution under cooling in an ice bath. the precipitated solid was filtered and dried to give ethyl 3-aminoisonicotinate (0.70 g, 42% yield). The filtrate was extracted with ethyl acetate, the organic phase was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give additional ethyl 3-aminoisonicotinate (0.30 g, 18% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 1.30 (3H, t, J = 7.1 Hz), 4.28 (2H, q, J = 7.1 Hz), 6.66 (2H, br.s), 7.45 (1H, d, J = 5.2 Hz), 7.73 (1H, d, J = 5.2 Hz), 8.23 (1H, s).
References
[1] Australian Journal of Chemistry, 1993, vol. 46, # 7, p. 987 - 993
[2] Patent: EP1844768, 2007, A1. Location in patent: Page/Page column 29-30
[3] Journal of Organic Chemistry, 1952, vol. 17, p. 547,553
[4] Bulletin de la Societe Chimique de France, 1992, # 1, p. 79 - 84
[5] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
3-AMINO-ISONICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9546 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
View Lastest Price from 3-AMINO-ISONICOTINIC ACID ETHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
14208-83-4
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-01-27 | 3-Amino-isonicotinic acid ethyl ester
14208-83-4
|
US $0.00 / KG | 1KG | 97.0% | 100 tons | Honest Joy Holdings Limited | |
 |
2019-07-06 | 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
14208-83-4
|
US $8.00 / kg | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
14208-83-4
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Amino-isonicotinic acid ethyl ester
14208-83-4
- US $0.00 / KG
- 97.0%
- Honest Joy Holdings Limited
-
- 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
14208-83-4
- US $8.00 / kg
- 99%
- Career Henan Chemical Co
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