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7-Methoxyflavone

7-Methoxyflavone structure

CAS No.: 22395-22-8

Chemical Name:: 7-Methoxyflavone

Synonyms: 7-METHOXYFLAVONE;7-methoxoyflavone;METHOXYFLAVONE, 7-;7-Methoxyflavone>7-methoxy-2-phenyl-chromone;JR-8980, 7-Methoxyflavone, 97%;7-methoxy-2-phenylchromen-4-one;7-Methoxyflavone, 10 mM in DMSO;7-methoxy-2-phenyl-chromen-4-one;7-Methoxy-2-phenyl-4H-benzopyran-4-one

CBNumber:: CB4735474

Molecular Formula:: C16H12O3

Molecular Weight:: 252.26

MDL Number:: MFCD00017462

MOL File:: 22395-22-8.mol

MSDS File:: SDS

Last updated:2026-02-02 18:10:39

Product description	Number	Pack Size	Price
7-Methoxyflavone >98.0%(GC)	M1423	1g	$51
7-Methoxyflavone >98.0%(GC)	M1423	5g	$158
7-Methoxy-2-phenyl-4H-chromen-4-one	M350288	2.5g	$110
7-METHOXYFLAVONE 95.00%	NUT0000094	5G	$955.83
7-Methoxy-2-phenyl-4H-chromen-4-one 95+%	119941	10g	$406
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7-Methoxyflavone Properties

Melting point	110-112 °C(lit.)
Boiling point	421.2±45.0 °C(Predicted)
Density	1.240±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Sealed in dry,Room Temperature
solubility	DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml
form	powder to crystal
color	White to Light yellow
InChI	InChI=1S/C16H12O3/c1-18-12-7-8-13-14(17)10-15(19-16(13)9-12)11-5-3-2-4-6-11/h2-10H,1H3
InChIKey	QKNDCRMJDZLFEG-UHFFFAOYSA-N
SMILES	C1(C2=CC=CC=C2)OC2=CC(OC)=CC=C2C(=O)C=1
LogP	3.470 (est)
CAS DataBase Reference	22395-22-8(CAS DataBase Reference)
FDA UNII	XK561AP5UR

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Safety Statements

24/25

WGK Germany

HS Code

29145019

NFPA 704

	1
0		0

7-Methoxyflavone price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M1423	7-Methoxyflavone >98.0%(GC)	22395-22-8	1g	$51	2025-07-31	Buy
TCI Chemical	M1423	7-Methoxyflavone >98.0%(GC)	22395-22-8	5g	$158	2025-07-31	Buy
TRC	M350288	7-Methoxy-2-phenyl-4H-chromen-4-one	22395-22-8	2.5g	$110	2021-12-16	Buy
American Custom Chemicals Corporation	NUT0000094	7-METHOXYFLAVONE 95.00%	22395-22-8	5G	$955.83	2021-12-16	Buy
Matrix Scientific	119941	7-Methoxy-2-phenyl-4H-chromen-4-one 95+%	22395-22-8	10g	$406	2021-12-16	Buy

Product number	Packaging	Price	Buy
M1423	1g	$51	Buy
M1423	5g	$158	Buy
M350288	2.5g	$110	Buy
NUT0000094	5G	$955.83	Buy
119941	10g	$406	Buy

7-Methoxyflavone Chemical Properties,Uses,Production

Description

7-Methoxyflavone is a natural compound and non-steroidal because it binds reversibly with aromatase which is an enzyme that helps produce estrogen through the conversion of androgen (testosterone) to estrogen. It has strong aromatase inhibiting properties, superior bioavailability, and strong resistance to hepatic metabolism/breakdown.

Definition

ChEBI: 7-Methoxyflavone is a member of flavonoids and an ether.

benefits

7-methoxyflavone is popular nowadays as one of the most powerful aromatase inhibitor and testosterone booster. It is isolated from Zornia brasiliensis. It might change how the body breaks down chemicals called hormones. Some people think this might cause the body to have more of the hormone called testosterone. Testosterone can help build muscle, but can also cause serious side effects.

Biological Activity

7-Methoxyflavone is a flavone that has been found in Z. brasiliensis and has diverse biological activities. It inhibits aromatase (IC50 = 1.9 μM in a cell-free assay) and LPS-induced nitric oxide (NO) production by 17.74% in RAW 264.7 macrophages when used at a concentration of 20 μM. 7-Methoxyflavone activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay and has antinociceptive effects in the acetic acid-induced writhing test in mice (ED50 = 82.5 μmol/kg).

Synthesis

1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione

52752-67-7

22395-22-8

1-(2-Hydroxyphenyl)-3-aryl-1,3-propanedione 1a (0.5 g) was mixed with malic acid (1.0 eq.) and placed in an oil bath preheated to 140 °C and reacted for 10 min; or in a microwave reactor for 5 min. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature and diluted by adding water (10 mL) and ethyl acetate (10 mL). Subsequently, solid NaHCO3 was added to neutralize the reaction mixture. The organic layer was separated and the aqueous layer was further extracted with ethyl acetate (2 x 10 mL). All organic extracts were combined and dried with anhydrous sodium sulfate and subsequently concentrated under vacuum. The crude product was purified by silica gel column chromatography using a mixed solvent system of hexane-ethyl acetate to give the target product 7-methoxy-2-phenyl-4H-benzopyran-4-one in high yield.

References

[1] Letters in Organic Chemistry, 2014, vol. 11, # 8, p. 601 - 605
[2] Heterocyclic Communications, 2007, vol. 13, # 1, p. 77 - 81
[3] Letters in Organic Chemistry, 2015, vol. 12, # 8, p. 574 - 583
[4] Letters in Organic Chemistry, 2016, vol. 13, # 10, p. 734 - 741
[5] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 5, p. 1919 - 1920

7-Methoxyflavone synthesis

Synthesis of 7-Methoxyflavone from Paeonol and Benzaldehyde

7-Methoxyflavone Preparation Products And Raw materials

Raw materials

(2Z)-2-benzylidene-6-methoxy-1-benzofuran-3(2H)-one 1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione 2'-hydroxy-4' methoxydihydrochalcone 4H-1-Benzopyran-4-one, 3-benzoyl-7-methoxy-2-phenyl- 1-(2,4-dimethoxyphenyl)-3-phenylpropane-1,3-dione

2-HYDROXY-1-(4-METHOXYPHENYL)-1-ETHANONE 7-METHOXYFLAVANONE Paeonol 4H-1-BENZOPYRAN-4-ONE, 2,3-DIHYDRO-7-METHOXY- 7-METHOXYISOFLAVONE

2-Iodo-5-Methoxyphenol (4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZENE Benzaldehyde Phenylacetylene

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Preparation Products

7-Methoxyflavone Suppliers

Global( 172)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58

View Lastest Price from 7-Methoxyflavone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-01	7-Methoxyflavone 22395-22-8	US $0.00 / removed		99.36%	10g	TargetMol Chemicals Inc.
2026-01-30	7-METHOXYFLAVONE 22395-22-8	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	7-Methoxyflavone 22395-22-8	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

7-Methoxyflavone
22395-22-8
US $0.00 / removed
99.36%
TargetMol Chemicals Inc.

7-METHOXYFLAVONE
22395-22-8
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

7-Methoxyflavone
22395-22-8
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

7-Methoxyflavone Spectrum

7-Methoxyflavone(22395-22-8)¹HNMR

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7-METHOXYFLAVONE METHOXYFLAVONE, 7- 2-Phenyl-7-methoxy-4H-1-benzopyran-4-one 7-methoxoyflavone JR-8980, 7-Methoxyflavone, 97% 7-methoxy-2-phenyl-chromen-4-one 7-methoxy-2-phenylchromen-4-one 7-methoxy-2-phenyl-chromone 7-Methoxy-2-phenyl-4H-benzopyran-4-one 7-Methoxyflavone> 4H-1-Benzopyran-4-one, 7-methoxy-2-phenyl- TIANFU-CHEM_ 7-Methoxyflavone,22395-22-8 7-Methoxyflavone, 10 mM in DMSO 22395-22-8 Heterocyclic Building Blocks Flavonoids Benzopyrans Building Blocks Mono-substituted Flavones Biochemistry Flavonoids Benzopyrans Building Blocks Heterocyclic Building Blocks