4-Hydroxy propranolol HCl
- CAS No.
- 14133-90-5
- Chemical Name:
- 4-Hydroxy propranolol HCl
- Synonyms
- Propranolol Impurity 10;4-Hydroxy propranolol HCl;(±)-4-Hydroxypropranolol HCl;rac-4-Hydroxy Propranolol HCl;Propranolol 4-Hydroxy Impurity;4-Hydroxy Propranolol HCl (Rac);(±)-4-Hydroxypropranolol-d7 HCl;4-HYDROXYPROPRANOLOL HYDROCHLORIDE;4-Hydroxy Propranolol HCL (Standard);Propranolol Impurity 21(Hydrochloride)
- CBNumber:
- CB4752444
- Molecular Formula:
- C16H21NO3.ClH
- Molecular Weight:
- 311.8
- MDL Number:
- MFCD06656370
- MOL File:
- 14133-90-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 156-158°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Red to Black |
| Stability | Hygroscopic |
| Major Application |
forensics and toxicology pharmaceutical (small molecule) |
| InChI | 1S/C16H21NO3.ClH/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16;/h3-8,11-12,17-19H,9-10H2,1-2H3;1H |
| InChIKey | ROUJENUXWIFONU-UHFFFAOYSA-N |
| SMILES | CC(C)NCC(O)COC1=CC=C(O)C2=CC=CC=C21.Cl |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
4-Hydroxy propranolol HCl price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 00881 | (±)-4-Hydroxypropranolol hydrochloride analytical standard | 14133-90-5 | 25 mg | $589 | 2026-04-30 | Buy |
| Cayman Chemical | 18630 | (±)-4-hydroxy Propranolol (hydrochloride) ≥95% | 14133-90-5 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 18630 | (±)-4-hydroxy Propranolol (hydrochloride) ≥95% | 14133-90-5 | 5mg | $223 | 2026-04-30 | Buy |
| Cayman Chemical | 18630 | (±)-4-hydroxy Propranolol (hydrochloride) ≥95% | 14133-90-5 | 10mg | $400 | 2026-04-30 | Buy |
| TRC | TRC-H952545-5MG | rac-4-Hydroxy Propranolol Hydrochloride >95%(HPLC) | 14133-90-5 | 5mg | $248 | 2026-06-03 | Buy |
4-Hydroxy propranolol HCl Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
The main metabolite of (R)-Propranolol
Uses
The main metabolite of (S)-Propranolol
Uses
A metabolite of Propranolol.
Biological Activity
(±)-4-hydroxy propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ars, β2-ars). also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ars, expressed in cardiac myocytes, mediate an increase in contractility by gs-dependent coupling to adenylyl cyclase.
in vitro
compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. when pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μm, the degrees of protection were increased against the glutathione loss in the endothelial cells. additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].
in vivo
rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. the response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].
IC 50
1.1 μm: inhibits lipid peroxidation in endothelial cells.
References
[1]. mak, i. potent antioxidant properties of 4-hydroxyl-propranolol. journal of pharmacology and experimental therapeutics. 2003; 308(1): 85-90.
[2]. fitzgerald, j., & o'donnell, s. pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. british journal of pharmacology. 1971; 43(1): 222-235.
4-Hydroxy propranolol HCl Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1949 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2503 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2971 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@yongstandards.com | China | 9995 | 55 |
