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2-Phenoxyaniline

2-Phenoxyaniline Structure
2-Phenoxyaniline structure
CAS No.
2688-84-8
Chemical Name:
2-Phenoxyaniline
Synonyms
Phenoxyaniline;2-Ade;NSC 39655;AKOS B020146;2-PhenoxyaniL;AURORA KA-7802;2-phenoxy-anilin;O-PHENOXYANILINE;2-PHENOXYANILINE;o-phenoxy-anilin
CBNumber:
CB4754493
Molecular Formula:
C12H11NO
Molecular Weight:
185.22
MDL Number:
MFCD00035765
MOL File:
2688-84-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:15:14
Product description Number Pack Size Price
2-Phenoxyaniline 99% 346683 25g $30.9
2-Phenoxyaniline 99% 346683 500g $344
2-Aminodiphenyl Ether >98.0%(GC)(T) A1142 25g $28
2-Aminodiphenyl Ether >98.0%(GC)(T) A1142 500g $297
2-Phenoxylaniline >95%(HPLC) TRC-P298200-5G 5g $177
More product size
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2-Phenoxyaniline Properties

Melting point 47-49 °C(lit.)
Boiling point 170 °C18 mm Hg(lit.)
Density 1.0936 (rough estimate)
refractive index 1.5300 (estimate)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Slightly soluble in chloroform and methanol.
pka 3.78±0.10(Predicted)
form Crystalline Powder or Flakes
color Brown to gray
BRN 777766
Stability Hygroscopic
InChI 1S/C12H11NO/c13-11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9H,13H2
InChIKey NMFFUUFPJJOWHK-UHFFFAOYSA-N
SMILES Nc1ccccc1Oc2ccccc2
CAS DataBase Reference 2688-84-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII T96D49XD9H
NIST Chemistry Reference 2-Aminodiphenyl ether(2688-84-8)
EPA Substance Registry System o-Phenoxyaniline (2688-84-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-22
Safety Statements  26-37/39-36/37/39-36
RIDADR  2811
WGK Germany  3
RTECS  BY7940000
Hazard Note  Irritant
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29222990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Toxicity LD50 ivn-mus: 212 mg/kg TXCYAC 8,347,77
REACH Registrations Inactive
NFPA 704
1
2 0

2-Phenoxyaniline price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 346683 2-Phenoxyaniline 99% 2688-84-8 25g $30.9 2026-04-30 Buy
Sigma-Aldrich 346683 2-Phenoxyaniline 99% 2688-84-8 500g $344 2026-04-30 Buy
TCI Chemical A1142 2-Aminodiphenyl Ether >98.0%(GC)(T) 2688-84-8 25g $28 2026-04-30 Buy
TCI Chemical A1142 2-Aminodiphenyl Ether >98.0%(GC)(T) 2688-84-8 500g $297 2026-04-30 Buy
TRC TRC-P298200-5G 2-Phenoxylaniline >95%(HPLC) 2688-84-8 5g $177 2026-06-03 Buy
Product number Packaging Price Buy
346683 25g $30.9 Buy
346683 500g $344 Buy
A1142 25g $28 Buy
A1142 500g $297 Buy
TRC-P298200-5G 5g $177 Buy

2-Phenoxyaniline Chemical Properties,Uses,Production

Chemical Properties

Whitetolightyellowcrystalpowde

Uses

2-Phenoxyaniline serves as an antiinflammatory agent that inhibits preferentially COX-2 over COX-1. It is used in the preparation of sodium primary amide complex, 4-methyl-2-(2-phenoxyphenyl)azo-phenol and 2-acetoaminodiphenyl ether. Further, it is used to form complexes with beta-cyclodextrin.

Uses

2-Phenoxyaniline may be used in the preparation of sodium primary amide complex, 2-PhOC6H4NHNa·NMe[(CH2)2NMe2]2. It was used in the preparation of 2-acetoaminodiphenyl ether. It may be used in the preparation of 4-methyl-2-(2-phenoxyphenyl)azo-phenol.

General Description

2-Phenoxyaniline forms crystalline 2:1 (host-to-guest) inclusion complexes with β-cyclodextrin.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.

Synthesis

Iodobenzene

591-50-4

2-Aminophenol

95-55-6

2-Phenoxyaniline

2688-84-8

General procedure: all reactions were carried out under air atmosphere. Iodobenzene (1.0 mmol), o-aminophenol (1.0 mmol), CuI (0.1 mmol), 1-(α-aminobenzyl)-2-naphthol (0.2 mmol), and K2CO3 (2.0 equiv.) were dissolved in 3 mL of DMSO, and the reaction was carried out for 24 hr at 120 °C. The reaction process was monitored by gas chromatography (GC). Upon completion of the reaction, the catalyst was removed by filtration and the product was extracted with ethyl acetate (EtOAc). The organic layers were combined and dried with anhydrous MgSO4 for 12 hours. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (10:1, v/v) to afford the target compound 2-aminodiphenyl ether.

References

[1] Synthetic Communications, 2014, vol. 44, # 17, p. 2468 - 2477
[2] Tetrahedron Letters, 2014, vol. 55, # 51, p. 7082 - 7088

2-Phenoxyaniline Preparation Products And Raw materials

Raw materials

Iodobenzene 2-NITRODIPHENYL ETHER 2-Aminophenol Potassium carbonate Dimethyl sulfoxide
Copper(l) iodide

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Preparation Products

Triclosan 4-Phenoxyaniline 1-IODO-2-PHENOXY-BENZENE 2-CHLORO-N-(2-PHENOXY-PHENYL)-ACETAMIDE 4-Bromo-2-phenoxyaniline

2-Phenoxyaniline Suppliers

Global( 387)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2452 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		13343047651 admin@zlchemi.com China 3689 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14320 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
Supplier Advantage
Henan Bao Enluo International TradeCo.，LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Standardpharm Co. Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58

View Lastest Price from 2-Phenoxyaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Phenoxyaniline pictures 2026-08-10 2-Phenoxyaniline
2688-84-8
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Phenoxyaniline pictures 2026-06-30 2-Phenoxyaniline
2688-84-8
 1KG 98 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Phenoxyaniline pictures 2025-04-15 2-Phenoxyaniline
2688-84-8
 $65.00 1kg 99% 5000kg/week Hebei Zhuanglai Chemical Trading Co.,Ltd

2-Phenoxyaniline Spectrum

2-Phenoxyaniline(2688-84-8)MS2-Phenoxyaniline(2688-84-8)1HNMR2-Phenoxyaniline(2688-84-8)13CNMR2-Phenoxyaniline(2688-84-8)IR12-Phenoxyaniline(2688-84-8)IR22-Phenoxyaniline(2688-84-8)Raman

2688-84-8(2-Phenoxyaniline)Related Search:

Phenylhydrazine PHENYL VALERATE Dimethyl ether C8E3 4,4'-Oxydiphthalic anhydride
Triclosan 4,4'-Oxydianiline Ethylbenzene Diphenyl ether 4-Nitro-2-phenoxyaniline
NiMesulide EP IMpurity E N-(Methylsulfonyl)-4'-nitro-2'-phenoxyMethanesulfonanilide (2-PHENOXY)METHYLSULFONYLANILINE 2-(p-tolyloxy)aniline 2-AMINO-4,4'-DICHLORODIPHENYL ETHER
5-Chloro-2-(2-chlorophenoxy)aniline Diethyl ether Phenoxazine

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AURORA KA-7802 2-AMINOPHENYL PHENYL ETHER 2-AMINODIPHENYL ETHER 2-PHENOXYANILINE AKOS B020146 O-PHENOXYANILINE 2-Ade 2-phenoxy-anilin 2-phenoxy-benzenamin 2-phenoxybenzenamine Aniline, 2-phenoxy- Aniline, o-phenoxy- Benzenamine, 2-phenoxy- o-Aminophenyl phenyl ether o-aminophenylphenylether o-phenoxy-anilin 2-Aminodiphenyl ether~2-Aminophenyl phenyl ether Aminodiphenylether,97% 2-Phonoxyaniline 2-Phenoxyaniline,99% 2-AMINODIPHENYLETHER(2-PHENOXYANILINE) 2-AMINODIPHENYL ETHER 97+% 2-Phenoxyaniline,98% Ortho Phenoxy Aniline (2-Amino Diphenyl Ether) 2-Aminophenyl Phenyl Ether 2-Phenoxyaniline Phenoxyaniline NiMesulide EP IMpurity C Nimesulide Impurity 3(Nimesulide EP Impurity C) Nimesulide impurity-C(EP/BP) 2-Phenoxylaniline 2-Aminodiphenyl Ether > 2-PhenoxyaniL Nimesulide EP Impurity C (2-phenoxyaniline) 2-Phenoxyaniline/2-Aminodiphenyl Ether 2-Amino-2’-Diphenyl Ether Ortho Amino Di Phenyl Ether (2 PHENOXY ANILINE) NIMESULIDE EP IMP C NSC 39655 2-Phenoxyaniline (Nimesulide Impurity) 2688-84-8 2688-84-4 C12H11O2N C11 to C37 Building Blocks Amines Organic Building Blocks Nitrogen Compounds