TN-16
- CAS No.
- 33016-12-5
- Chemical Name:
- TN-16
- Synonyms
- TN-16;Nsc 239274;TN-16, 10 mM in DMSO;3-(ANILINOETHYLIDENE)-5-BENZYLPYRROLIDINE-2,4-DIONE;3-(1-ANILINOETHYLIDENE)-5-BENZYLPYRROLIDINE-2,4-DIONE;TN-16,TN16,TN 16,inhibit,Microtubule/Tubulin,Inhibitor;5-Benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione;2,4-Pyrrolidinedione, 3-(1-anilinoethylidene)-5-benzyl- (8ci);3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione;2,4-Pyrrolidinedione, 3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-
- CBNumber:
- CB4774585
- Molecular Formula:
- C19H18N2O2
- Molecular Weight:
- 306.36
- MDL Number:
- MFCD02684017
- MOL File:
- 33016-12-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H400 |
| Precautionary statements | P273-P280-P302+P352 |
| Hazard Codes | Xi,N |
| Risk Statements | 43-50/53 |
| Safety Statements | 36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
TN-16 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T7580 | TN-16 ≥98% (HPLC) | 33016-12-5 | 5mg | $136 | 2025-07-31 | Buy |
| Sigma-Aldrich | T7580 | TN-16 ≥98% (HPLC) | 33016-12-5 | 25mg | $424 | 2025-07-31 | Buy |
| TCI Chemical | T3877 | TN-16 | 33016-12-5 | 25MG | $144 | 2025-07-31 | Buy |
| TCI Chemical | T3877 | TN-16 | 33016-12-5 | 100MG | $397 | 2025-07-31 | Buy |
| Cayman Chemical | 21222 | TN-16 ≥98% | 33016-12-5 | 10mg | $44 | 2024-03-01 | Buy |
TN-16 Chemical Properties,Uses,Production
Uses
TN-16 is an antitumor drug that blocks microtubule assembly. Tubulin inhibitor.
Biological Activity
3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor th at could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.', 'Inhibitor of microtubule assembly', 'TN-16 is a synthetic compound th at blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.
TN-16 Preparation Products And Raw materials
Raw materials
Preparation Products
TN-16 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3944 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28387 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2989 | 58 |
