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N-(tert-Butoxycarbonyl)-L-phenylalanine

N-(tert-Butoxycarbonyl)-L-phenylalanine structure

CAS No.: 13734-34-4

Chemical Name:: N-(tert-Butoxycarbonyl)-L-phenylalanine

Synonyms: BOC-PHE-OH;BOC-PHE;BOC-L-PHE-OH;BOC-L-PHE;BOC-L-PHENYLALANINE;N-BOC-L-PHENYLALANINE;BOC-PHENYLALANINE;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-;BOC-ph-OH;BOC Phenly Alanine

CBNumber:: CB4781305

Molecular Formula:: C14H19NO4

Molecular Weight:: 265.3

MDL Number:: MFCD00002663

MOL File:: 13734-34-4.mol

MSDS File:: SDS

Last updated:2025-07-04 15:25:59

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N-(tert-Butoxycarbonyl)-L-phenylalanine Properties

Melting point	85-87 °C(lit.)
Boiling point	408.52°C (rough estimate)
Density	1.1356 (rough estimate)
refractive index	24.5 ° (C=1, EtOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol, dichloromethane, dimethylformamide and N-methyl-2-pyrrolidone.
form	Fine Crystalline Powder
pka	3.88±0.10(Predicted)
color	White
optical activity	[α]20/D +25±1°, c = 1% in ethanol
BRN	2219729
InChI	InChI=1S/C14H19NO4/c1-14(2,3)19-13(18)15-11(12(16)17)9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/t11-/m0/s1
InChIKey	ZYJPUMXJBDHSIF-NSHDSACASA-N
SMILES	C(O)(=O)[C@H](CC1=CC=CC=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference	13734-34-4(CAS DataBase Reference)
EPA Substance Registry System	L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- (13734-34-4)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280-P271

Hazard Codes

Xn,Xi

Risk Statements

36-22-36/37/38-20/21/22

Safety Statements

39-26-36-24/25

WGK Germany

TSCA

Yes

HS Code

29242990

NFPA 704

	1
		0

N-(tert-Butoxycarbonyl)-L-phenylalanine price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53006	Boc-Phe-OH Novabiochem?	13734-34-4	25g	$57.6	2025-07-31	Buy
Sigma-Aldrich	8.53006	Boc-Phe-OH Novabiochem?	13734-34-4	100g	$66	2025-07-31	Buy
Sigma-Aldrich	8.53006	Boc-Phe-OH Novabiochem^®	13734-34-4	1 kg	$1290	2025-07-31	Buy
Sigma-Aldrich	8.53006	Boc-Phe-OH Novabiochem^®	13734-34-4	1 kg	$1290	2025-07-31	Buy
Sigma-Aldrich	15480	Boc-Phe-OH ≥99.0% (T)	13734-34-4	5g	$40.4	2025-07-31	Buy

Product number	Packaging	Price	Buy
8.53006	25g	$57.6	Buy
8.53006	100g	$66	Buy
8.53006	1 kg	$1290	Buy
8.53006	1 kg	$1290	Buy
15480	5g	$40.4	Buy

N-(tert-Butoxycarbonyl)-L-phenylalanine Chemical Properties,Uses,Production

Chemical Properties

N-(tert-Butoxycarbonyl)-L-phenylalanine is white fine crystalline powder

Uses

N-(tert-Butoxycarbonyl)-L-phenylalanine is used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.

Uses

N-Boc-L-phenylalanine is a derivative of Phenylalanine used in enantioselective hydrolysis of amino acid esters.

Preparation

Sodium hydroxide (4.4 g, 0.11 mol) was placed in a flask, and dissolved in water (110 mL). Phenylalanine (16.5 g, 0.1 mol) was added, the suspension was stirred until a solution was obtained, and then tert-butanol (75 mL) was added. Boc2O (22.3 g, 0.12 mol) was then added with stirring over a period of 1 h, keeping the mixture near 0 ℃. A white precipitate was produced, and at the end of the addition the pH had dropped to 7.5–8.5. The mixture was then carefully acidified by the slow, continuous addition of saturated citric acid to give the product N-tert-butoxycarbonyl-L-phenylalanine (21.5 g, 81%); mp 85℃; [a]21D = t25:5 (c = 1, ethanol).

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

N-(tert-Butoxycarbonyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials

L-Phenylalanine 1,4-Dioxane BOC-D-Phenylalanine BOC-DL-PHE-OH

Preparation Products

N-Boc-L-Phenylalaninol N-SUCCINYL-L-PHENYLALANINE P-NITROANILIDE (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate) H-PHE-TRP-OH TMC-58B

Boc-Phe-Phe-OH ANGIOTENSIN I, HUMAN DELTORPHIN (S)-3-(Boc-amino)-4-phenylbutyric acid ANGIOTENSIN II, HUMAN

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N-(tert-Butoxycarbonyl)-L-phenylalanine Suppliers

Global( 660)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+8617390183901	cynthia@enlaibio.com	China	1100	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20195	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	884	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shaanxi Xianhe Biotech Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55

View Lastest Price from N-(tert-Butoxycarbonyl)-L-phenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-30	Boc-Phe-OH 13734-34-4	US $0.00 / Kg/Drum	1KG	98%min	1000kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2025-08-29	Boc-Phe-OH 13734-34-4	US $0.00-0.00 / kg	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2025-08-29	N-(tert-Butoxycarbonyl)-L-phenylalanine 13734-34-4	US $0.00 / KG	1KG	0.99	1000KG	Shaanxi Xianhe Biotech Co., Ltd

Boc-Phe-OH
13734-34-4
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-Phe-OH
13734-34-4
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-(tert-Butoxycarbonyl)-L-phenylalanine
13734-34-4
US $0.00 / KG
0.99
Shaanxi Xianhe Biotech Co., Ltd

N-(tert-Butoxycarbonyl)-L-phenylalanine Spectrum

N-(tert-Butoxycarbonyl)-L-phenylalanine(13734-34-4)MS N-(tert-Butoxycarbonyl)-L-phenylalanine(13734-34-4)¹HNMR N-(tert-Butoxycarbonyl)-L-phenylalanine(13734-34-4)¹³CNMR N-(tert-Butoxycarbonyl)-L-phenylalanine(13734-34-4)IR1 N-(tert-Butoxycarbonyl)-L-phenylalanine(13734-34-4)IR2 N-(tert-Butoxycarbonyl)-L-phenylalanine(13734-34-4)Raman

13734-34-4(N-(tert-Butoxycarbonyl)-L-phenylalanine)Related Search:

L-Alanine BOC-Glycine Boc-D-Glutamine BOC-MET-ONP BOC-GLU(OME)-OH

Boc-L-Pyroglutamic acid methyl ester Boc-L-glutamic acid γ-allyl ester BOC-TYR(ET)-OH BOC-PHE-OSU 4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine

BOC-4-NITRO-L-PHENYLALANINE BOC-L-4-Chlorophe Boc-N-methyl-L-phenylalanine N-tert-Butoxycarbonyl-L-phenylalanine amide BOC-D-Phenylalanine

N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE ACID HYDRAZIDE N-tert-Butoxycarbonyl-DL-phenylalanine BOC-4-IODO-L-PHENYLALANINE

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n-[(1,1-dimethylethoxy)carbonyl]-l-phenylalanin L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- N-(tert-Butoxycarbonyl)-L-phenylalanine ,98.5% Boc-L-phenylalanine ,98% (2S)-2-(tert-Butoxycarbonylamino)-3-phenylpropionic acid (S)-2-(tert-Butoxycarbonylamino)-3-phenylpropanoic acid N-(tert-Butyloxycarbonyl)-L-phenylalanine N-(tert-butoxycarbonyl)-L-phenylalaninal Boc-L-phenylalanine ,98.5% 2-BOC-AMINO-3-PHENYL-PROPIONIC ACID Boc-L-phenylalanine,N-(tert-Butoxycarbonyl)-L-phenylalanine L-PHENYLALANINE-N-T-BOC (S)-N-(tert-Butoxycarbonyl)phenylalanine tert-Butoxycarbonyl-L-phenylalanine N-Boc-L-phenylalanine Boc-Phe-OH (2S)-2-{[(tert-butoxy)carbonyl]aMino}-3-phenylpropanoic acid Boc-Phe-OH >=99.0% (T) N-(tert-Butoxycarbonyl)-L-phenylalanine SynonyMs N-[(1,1-DiMethylethoxy)carbonyl]-L-phenylalanine Boc-L-phenylalanine≥ 99% (HPLC) Tert-Butoxycarbonyl L-Phenylalanine (BOC-L Phenylalanine) BOC-L-Phenylalanine, 99+% BOC-L-Phenylalanine(Boc-Phe-OH) N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE(BOC-L-PHE-OH) 2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONIC ACID N-Butoxycarbonyl-L-phenylalanine N-T-BOC-L-PHENYLALANINE FREE ACID N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE, 99+% BOC-PHE-OH BOC-PHENYLALANINE BOC-PHE BOC-L-PHE BOC-L-PHENYLALANINE BOC-L-PHENYLALANINE-OH BOC-L-PHE-OH Boc-Phe-OH (Boc-L-Phenylalanine) N-ALPHA-T-BUTYLOXYCARBONYL-L-PHENYLALANINE (2R)-3-phenyl-2-(tert-butoxycarbonylamino)propanoic acid BOC Phenly Alanine BOC-L-PHENYLALANINE extrapure N-(tert-Butoxycarbonyl)-L-phenylalanine, Boc-L-phenylalanine N-TERT-BUTYLOXYCARBONYL-DL-PHENYLALANINE N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE N-T-BOC-L-PHENYLALANINE N-T-BUTOXYCARBONYL-L-PHENYLALANINE N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanine N-BOC-L-PHENYLALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-L-PHENYLALANINE N-ALPHA-T-BOC-L-PHENYLALANINE T-BUTYLOXYCARBONYL-L-PHENYLALANINE TBOC-L-PHENYLALANINE (S)-2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONIC ACID RARECHEM AL BE 0755 N-Boc-L-phenylalanine,99%e.e. (Tert-Butoxy)Carbonyl Phe-OH (2S-2-[(2-MethylpropaN-2-Yloxycarbonylamino]-3-Phenylpropanoic Acid N-(tert-Butoxycarbonyl)-L-phenylalanine > BOC-ph-OH