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Telatinib mesylate

Telatinib mesylate Structure
Telatinib mesylate structure
CAS No.
332013-26-0
Chemical Name:
Telatinib mesylate
Synonyms
Telatinib mesylate;Telatinib mesylate (Bay 57-9352 mesylate);4-(((4-((4-chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide methanesulfonate
CBNumber:
CB48055013
Molecular Formula:
C21H20ClN5O6S
Molecular Weight:
505.93
MDL Number:
MOL File:
332013-26-0.mol
Last updated:2026-01-05 11:31:08
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Telatinib mesylate Properties

form Solid
color White to off-white
FDA UNII 571LVA9UMS
NCI Drug Dictionary telatinib mesylate

Telatinib mesylate Chemical Properties,Uses,Production

Uses

Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively[1].

in vivo

Telatinib (15 mg/kg; oral dministration; every 2nd and 3rd day; total 12 times; male athymic NCR (nu/nu) nude mice) with Doxorubicin (1.8 mg/kg) significantly decreases the growth rate and tumor size of ABCG2 overexpressing tumors in a xenograft nude mouse model[2].

Animal Model:Male athymic NCR (nu/nu) nude mice (13-15 g, age 4-5 weeks) injected with H460 and H460/MX20 cells[2]
Dosage:15 mg/kg
Administration:Oral dministration; every 2nd and 3rd day; total 12 times
Result:With Doxorubicin (1.8 mg/kg) significantly decreased the growth rate and tumor size of ABCG2 overexpressing tumors in a xenograft nude mouse model.

IC 50

VEGFR2: 6 nM (IC50); VEGFR3: 4 nM (IC50); PDGFRα: 15 nM (IC50); c-Kit: 1 nM (IC50)

References

[1] Steeghs N, et al.Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor.Clin Cancer Res. 2008 Jun 1;14(11):3470-6. DOI:10.1158/1078-0432.CCR-07-5050
[2] [2] Sodani K, et al. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Biochem Pharmacol. 2014 May 1;89(1):52-61. DOI:10.1016/j.bcp.2014.02.012

Telatinib mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

Telatinib mesylate Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39042 58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 28-83379370 13880556291 tcy@tcypharm.com China 510 57
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 7229 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@tcypharm.com China 597 55
InvivoChem 13549236410 sales@invivochem.cn China 6753 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24964 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5002 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 57
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Kaixin Chemical (Hong Kong) Limited 55
InvivoChem 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58

View Lastest Price from Telatinib mesylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Telatinib mesylate pictures 2026-01-05 Telatinib mesylate
332013-26-0
 US $43.00-67.00 / mg 10g TargetMol Chemicals Inc.
Telatinib mesylate 4-(((4-((4-chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide methanesulfonate Telatinib mesylate (Bay 57-9352 mesylate) 332013-26-0