Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]-
![Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]- Structure](CAS/20210111/GIF/1417742-86-9.gif)
- CAS No.
- 1417742-86-9
- Chemical Name:
- Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]-
- Synonyms
- Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]-
- CBNumber:
- CB48130006
- Molecular Formula:
- C26 H27 F3 N2 O3
- Molecular Weight:
- 472.5
- MDL Number:
- MOL File:
- 1417742-86-9.mol
Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]- Properties
| Boiling point | 633.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| form | Solid |
| pka | 4.35±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | SS2LQQ8094 |
Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]- Chemical Properties,Uses,Production
Uses
Vorbipiprant (CR6086) is an EP4 receptor antagonist, serving as a targeted immunomodulator. Thus, Vorbipiprant is also a potential immune checkpoint inhibitor, to turn cold tumors into hot tumors. Vorbipiprant also antagonizes PGE2-stimulated cAMP production (IC50=22 nM). Vorbipiprant exhibit striking DMARD effects in rodents, and anti-inflammatory activity to inhibt immune-mediated inflammatory diseases[1][2].
References
[1] Caselli G, et al. Pharmacological characterisation of CR6086, a potent prostaglandin E2?receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug. Arthritis Res Ther. 2018 Mar 1;20(1):39. DOI:10.1186/s13075-018-1537-8
[2] Caselli G, et al. Combination of the EP4 antagonist CR6086 and anti-PD-1 monoclonal antibody inhibits tumor growth in a microsatellite stable colorectal cancer in mice[J]. Cancer Research, 2020, 80(16_Supplement): 2208-2208.
Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzoic acid, 4-[1-[[[6-[[4-(trifluoromethyl)phenyl]methyl]-6-azaspiro[2.5]oct-5-yl]carbonyl]amino]cyclopropyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4783 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 26070 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 58 |
| TargetMol Chemicals Inc. | 58 |
