BENZOTHIOPHENE-4-CARBOXYLIC ACID
- CAS No.
- 10134-95-9
- Chemical Name:
- BENZOTHIOPHENE-4-CARBOXYLIC ACID
- Synonyms
- Fs002050;AKOS BC-0215;4-Benzothiophenecarboxylic acid;BENZOTHIOPHENE-4-CARBOXYLIC ACID;1-benzothiophene-4-carboxylic acid;Benzo[b]thiophene-4-carboxylic acid;BENZO[B]THIOPHENE-7-CARBOXYLIC ACID
- CBNumber:
- CB4816146
- Molecular Formula:
- C9H6O2S
- Molecular Weight:
- 178.21
- MDL Number:
- MFCD01929340
- MOL File:
- 10134-95-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H302 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2934999090 |
BENZOTHIOPHENE-4-CARBOXYLIC ACID price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB142272 | Benzo[b]thiophene-4-carboxylic acid | 10134-95-9 | 100mg | $84 | 2021-12-16 | Buy |
| Apolloscientific | OR400932 | Benzo[b]thiophene-4-carboxylic acid | 10134-95-9 | 250mg | $122 | 2021-12-16 | Buy |
| SynQuest Laboratories | 6H21-1-0B | Benzo[b]thiophene-4-carboxylic acid | 10134-95-9 | 250mg | $144 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB142272 | Benzo[b]thiophene-4-carboxylic acid | 10134-95-9 | 250mg | $167.5 | 2021-12-16 | Buy |
| Matrix Scientific | 119518 | Benzo[b]thiophene-4-carboxylic acid 95+% | 10134-95-9 | 1g | $684 | 2021-12-16 | Buy |
BENZOTHIOPHENE-4-CARBOXYLIC ACID Chemical Properties,Uses,Production
Synthesis
![4-Bromobenzo[b]thiophene](/CAS/GIF/5118-13-8.gif)
5118-13-8
124-38-9
10134-95-9
Benzo[b]thiophene-4-carboxylic acid was prepared as follows: a small amount of iodine crystals was added as initiator to a stirring suspension of magnesium (Mg, 4.79 g, 197 mmol) in anhydrous tetrahydrofuran (THF, 100 mL) under nitrogen protection. Subsequently, a solution of 4-bromobenzo[b]thiophene (40.0 g, 188 mmol) in anhydrous THF (150 mL) was added slowly and dropwise. Initially, only 5% of the total amount (~1 mL) was added to initiate the reaction, after which the remaining solution was added at a rate that maintained the reaction temperature at 50-55 °C, a process that took about 30 min. After addition, the reaction mixture was continued to be stirred at 50°C for 1 hour. After most of the magnesium has been consumed, the reaction is cooled to 23°C and carbon dioxide (CO2) gas produced from dry ice is passed into the solution. The reaction is exothermic and the solution temperature needs to be maintained at about 23°C by an ice bath. The gas is continuously vented for 15-20 minutes until a large amount of precipitate generation is observed. Upon completion of the reaction, the reaction is carefully quenched with 10% aqueous hydrochloric acid (HCl) solution at 0°C. Saturated aqueous sodium chloride solution was added and the mixture was extracted with ethyl acetate (EtOAc). The organic phase was extracted with 2 M aqueous sodium hydroxide (NaOH) and subsequently the aqueous phase was acidified to pH 1 with 37% aqueous HCl to form a suspension. After filtration and drying, benzo[b]thiophene-4-carboxylic acid was obtained as a white solid (24.9 g, 74% yield).
References
[1] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 18
BENZOTHIOPHENE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
BENZOTHIOPHENE-4-CARBOXYLIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
View Lastest Price from BENZOTHIOPHENE-4-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-12 | BENZOTHIOPHENE-4-CARBOXYLIC ACID
10134-95-9
|
US $3.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- BENZOTHIOPHENE-4-CARBOXYLIC ACID
10134-95-9
- US $3.00 / KG
- 99%
- Career Henan Chemical Co
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